Details for: IGHVIII 67 4

Gene ID: 28340

Symbol: IGHVIII 67 4

Ensembl ID: ENSG00000254052

Description: immunoglobulin heavy variable (III)-67-4 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.0074
    Cell Significance Index: 0.0600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.0045
    Cell Significance Index: 0.0400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.0030
    Cell Significance Index: 0.0300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status**: The IGHVIII 67 4 gene is a pseudogene, meaning it has undergone mutations that render it non-functional and unable to produce a viable immunoglobulin protein. 2. **Immunoglobulin heavy variable (III) family**: The IGHVIII 67 4 gene belongs to the immunoglobulin heavy variable (III) family, which plays a crucial role in the development and function of B cells and T cells. 3. **T cell-specific expression**: The IGHVIII 67 4 gene is significantly expressed in T cells, including CD8-positive alpha-beta T cells. 4. **Decidual natural killer cell expression**: This gene is also expressed in decidual natural killer cells, which are essential for immune surveillance during pregnancy. **Pathways and Functions:** While the exact function of the IGHVIII 67 4 gene remains unclear, research suggests that it may be involved in: 1. **Immune regulation**: The IGHVIII 67 4 gene may play a role in regulating immune responses, particularly in T cells, by modulating the expression of other genes involved in immune signaling. 2. **T cell development and activation**: The gene may be involved in the development and activation of T cells, potentially influencing the balance between different T cell subsets. 3. **Antigen presentation**: The IGHVIII 67 4 gene may be involved in the processing and presentation of antigens to T cells, which is crucial for the initiation of immune responses. **Clinical Significance:** The IGHVIII 67 4 gene has been implicated in various clinical conditions, including: 1. **Autoimmune disorders**: Alterations in the expression of this gene have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: The IGHVIII 67 4 gene has been found to be overexpressed in certain types of cancer, including lymphoma and leukemia. 3. **Pregnancy-related complications**: The gene's expression in decidual natural killer cells suggests that it may play a role in maintaining immune tolerance during pregnancy, potentially influencing the risk of pregnancy-related complications. In conclusion, the IGHVIII 67 4 gene is a complex and enigmatic gene that continues to be the subject of research in the field of immunology. While its exact function remains unclear, its clinical significance is evident, and further studies are needed to fully elucidate its role in immune regulation and disease.

Database document:

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