Details for: IGHVIII 47 1

Gene ID: 28344

Symbol: IGHVIII 47 1

Ensembl ID: ENSG00000253862

Description: immunoglobulin heavy variable (III)-47-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0130
    Cell Significance Index: -0.1700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0134
    Cell Significance Index: -0.1500
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.0182
    Cell Significance Index: -0.2200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0197
    Cell Significance Index: -0.2100
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0199
    Cell Significance Index: -0.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGHVIII 47 1 is classified as a pseudogene, which implies that it lacks the ability to produce a functional immunoglobulin heavy chain. However, this does not necessarily preclude its involvement in cellular processes, as pseudogenes can still influence gene expression and cellular behavior. 2. **Widespread expression:** IGHVIII 47 1 is expressed in multiple cell types, including those involved in immune responses, suggesting a broader functional scope beyond its pseudogene status. 3. **Cell type specificity:** The expression of IGHVIII 47 1 is not limited to specific cell types, highlighting its potential role in regulating cell-to-cell interactions and immune responses. **Pathways and Functions:** 1. **Cell signaling:** IGHVIII 47 1 may participate in cell signaling pathways, influencing cell proliferation, differentiation, and survival. The expression of this gene in various cell types suggests that it could play a role in regulating immune responses and tissue homeostasis. 2. **Gene regulation:** IGHVIII 47 1 may act as a regulatory element, influencing the expression of nearby genes or participating in non-coding RNA-mediated processes. 3. **Immune system regulation:** The expression of IGHVIII 47 1 in immune cells, such as plasma cells and thymocytes, suggests that it may play a role in regulating immune system function and response. **Clinical Significance:** 1. **Immunological disorders:** The expression of IGHVIII 47 1 in immune cells may be associated with immunological disorders, such as autoimmune diseases or cancer. Further investigation is needed to determine the functional implications of this gene in these conditions. 2. **Cancer biomarkers:** The expression of IGHVIII 47 1 in certain cell types may serve as a potential biomarker for cancer diagnosis or progression. 3. **Gene therapy:** Understanding the functional implications of IGHVIII 47 1 may provide insights into the development of novel gene therapy strategies for immunological disorders. In conclusion, the IGHVIII 47 1 gene, despite its pseudogene status, exhibits a complex and multifaceted profile, influencing cell signaling, gene regulation, and immune system function. Further research is necessary to fully elucidate the functional implications of this enigmatic gene and its potential role in immunological disorders and cancer.

Database document:

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