Details for: IGHVII 49 1

Gene ID: 28364

Symbol: IGHVII 49 1

Ensembl ID: ENSG00000253386

Description: immunoglobulin heavy variable (II)-49-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0003
    Cell Significance Index: 0.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0022
    Cell Significance Index: -0.0200
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.0062
    Cell Significance Index: -0.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Immunoglobulin Heavy Variable (II) Family**: IGHVII 49 1 belongs to the immunoglobulin heavy variable (II) family, which is distinct from the more well-studied heavy chains (IgH, IgD, and IgM). The heavy chains of the II family are primarily involved in the activation of immune cells and the regulation of immune responses. 2. **Pseudogene**: IGHVII 49 1 is a pseudogene, meaning it possesses a functional gene sequence but lacks a complete coding region. This characteristic suggests that the gene may have undergone degeneration or been silenced in certain cell types, possibly due to gene duplication or rearrangement events. 3. **Diverse Cell Type Expression**: IGHVII 49 1 is expressed in a wide range of cell types, including megakaryocyte-erythroid progenitor cells, CD4-positive alpha-beta memory T cells, plasma cells, double-positive alpha-beta thymocytes, and megakaryocytes. This diverse expression pattern hints at the gene's potential role in regulating immune cell development and function. **Pathways and Functions:** 1. **Immune Cell Development and Function**: IGHVII 49 1's expression in various immune cell types suggests that it may play a role in the development and regulation of immune responses. The gene's involvement in the activation of immune cells and the regulation of immune responses is further supported by its expression in CD4-positive alpha-beta memory T cells and plasma cells. 2. **Cell Signaling and Cytokine Regulation**: IGHVII 49 1's expression in megakaryocytes and megakaryocyte-erythroid progenitor cells may be linked to the regulation of cell signaling pathways and cytokine production. The gene's involvement in these processes could influence the development and function of these cells. 3. **Gene Regulation and Epigenetics**: The IGHVII 49 1 gene's pseudogene status and diverse expression pattern raise questions about its regulation and epigenetic control. Further investigation into the gene's expression and regulation patterns may reveal insights into the mechanisms underlying immune cell development and function. **Clinical Significance:** 1. **Immunological Disorders**: The IGHVII 49 1 gene's expression in various immune cell types and its potential role in immune cell development and function make it an attractive candidate for studying immunological disorders, such as autoimmune diseases and immunodeficiency conditions. 2. **Cancer Research**: IGHVII 49 1's expression in plasma cells and its potential involvement in cell signaling pathways and cytokine regulation may be linked to cancer development and progression. Further investigation into the gene's role in cancer may reveal new therapeutic targets. 3. **Gene Therapy and Immunotherapy**: The IGHVII 49 1 gene's expression in various immune cell types and its potential role in immune cell development and function make it an attractive candidate for gene therapy and immunotherapy applications. The gene's involvement in immune cell regulation and function may be exploited to develop novel immunotherapeutic strategies. In conclusion, the IGHVII 49 1 gene's unique expression profile and potential role in immune cell development and function warrant further investigation into its immunological significance. Further studies on this gene may reveal new insights into the mechanisms underlying immune cell development and function, and may ultimately lead to the development of novel immunotherapeutic strategies.

Database document:

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