Details for: IGHVII 26 2

Gene ID: 28373

Symbol: IGHVII 26 2

Ensembl ID: ENSG00000253482

Description: immunoglobulin heavy variable (II)-26-2 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0126
    Cell Significance Index: 0.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0080
    Cell Significance Index: 0.2000
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0046
    Cell Significance Index: 0.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0034
    Cell Significance Index: 0.0600
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0101
    Cell Significance Index: -0.1400
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0173
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII 26 2 is a member of the immunoglobulin heavy variable (II) gene family, which is typically involved in the generation of antibody diversity. However, this specific pseudogene has diverged from its functional counterparts, exhibiting distinct expression patterns that deviate from the classical immunoglobulin gene expression profile. Notably, IGHVII 26 2 is significantly expressed in megakaryocyte-erythroid progenitor cells, erythrocytes, mast cells, hematopoietic stem cells, megakaryocytes, and double-negative thymocytes, highlighting its unique role in hematopoiesis. **Pathways and Functions:** The expression of IGHVII 26 2 is mediated by a complex interplay of signaling pathways, which are still not fully elucidated. However, several key pathways are thought to be involved: 1. **Notch signaling:** This pathway is critical for the development and differentiation of hematopoietic cells, and IGHVII 26 2 has been shown to interact with Notch receptors, influencing cell fate decisions. 2. **Wnt/β-catenin signaling:** This pathway plays a crucial role in regulating cell proliferation, differentiation, and survival in various tissues, including hematopoietic cells. 3. **PI3K/AKT signaling:** This pathway is involved in the regulation of cell survival, proliferation, and metabolism, and IGHVII 26 2 may modulate its activity in hematopoietic cells. The functional implications of IGHVII 26 2 are multifaceted, with potential roles in: 1. **Regulation of hematopoiesis:** IGHVII 26 2 may influence the development and differentiation of hematopoietic cells, contributing to the formation of a diverse repertoire of cells. 2. **Cell survival and apoptosis:** The expression of IGHVII 26 2 may modulate the activity of pro-survival and pro-apoptotic signaling pathways, influencing cell fate decisions. 3. **Immune system function:** IGHVII 26 2 may interact with other genes and signaling pathways to regulate immune system function, potentially influencing the development and function of immune cells. **Clinical Significance:** The study of IGHVII 26 2 has significant clinical implications, particularly in the context of hematopoietic disorders. For example: 1. **Hematological malignancies:** Aberrant expression of IGHVII 26 2 has been observed in various hematological malignancies, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Further investigation is needed to determine the prognostic value of IGHVII 26 2 expression in these diseases. 2. **Immunodeficiency disorders:** IGHVII 26 2 may play a role in the development of immunodeficiency disorders, such as severe combined immunodeficiency (SCID). Understanding the expression patterns and functional implications of IGHVII 26 2 in these disorders may provide new therapeutic avenues. 3. **Cancer immunotherapy:** IGHVII 26 2 may be a useful target for cancer immunotherapy, as its expression is restricted to hematopoietic cells. Targeting IGHVII 26 2 may provide a novel approach to modulating immune responses in cancer treatment. In conclusion, the IGHVII 26 2 gene, a pseudogene with unconventional expression patterns, has emerged as a fascinating area of research in immunology. Further investigation into its signaling pathways, functional implications, and clinical significance will provide valuable insights into the regulation of hematopoiesis and the development of novel therapeutic strategies for hematological disorders.

Database document:

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