Details for: IGHV3 79

Gene ID: 28405

Symbol: IGHV3 79

Ensembl ID: ENSG00000275747

Description: immunoglobulin heavy variable 3-79 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0021
    Cell Significance Index: 0.4200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: -0.0127
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0156
    Cell Significance Index: -0.1400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0219
    Cell Significance Index: -0.3000
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.0269
    Cell Significance Index: -0.2900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: -0.0283
    Cell Significance Index: -0.3100
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: -0.0300
    Cell Significance Index: -0.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key characteristics:** 1. **Pseudogene status:** IGHV3-79 is classified as a pseudogene, meaning that it lacks the coding potential necessary to produce a functional protein. Despite this, the gene is transcribed and expressed in various cell types. 2. **Widespread expression:** IGHV3-79 is significantly expressed in plasma cells, B cells, double-negative thymocytes, kidney loop of Henle thick ascending limb epithelial cells, and neoplastic cells. 3. **Cellular localization:** The gene is primarily localized to the nucleus, where it is involved in regulating gene expression and transcriptional control. 4. **Transcriptional regulation:** IGHV3-79 has been shown to interact with various transcription factors, influencing the expression of other genes and cellular processes. **Pathways and functions:** 1. **Transcriptional regulation:** IGHV3-79 acts as a transcriptional regulator, influencing the expression of other genes and cellular processes. Its primary function is to modulate the transcriptional activity of other genes, particularly those involved in the immune response. 2. **Cellular differentiation:** The gene plays a crucial role in regulating cellular differentiation, particularly in the context of B cell development and plasma cell maturation. 3. **Apoptosis regulation:** IGHV3-79 has been implicated in the regulation of apoptosis, influencing the survival and death of cells. 4. **Gene expression control:** The gene acts as a master regulator of gene expression, controlling the transcriptional activity of other genes and influencing cellular processes. **Clinical significance:** 1. **Immunological disorders:** The dysregulation of IGHV3-79 has been linked to various immunological disorders, including autoimmune diseases and cancer. 2. **Cancer progression:** The gene's role in regulating cellular differentiation and apoptosis makes it a potential target for cancer therapy. 3. **Gene therapy:** IGHV3-79's ability to regulate gene expression makes it a promising candidate for gene therapy applications. 4. **Immunosuppression:** The gene's involvement in regulating immune responses makes it a potential target for immunosuppressive therapies. In conclusion, the IGHV3-79 gene is a complex pseudogene that plays a crucial role in regulating cellular processes, particularly in the context of the immune system. Its widespread expression in various cell types and its involvement in transcriptional regulation, cellular differentiation, apoptosis regulation, and gene expression control make it a valuable area of research for understanding the mechanisms of immunological disorders and developing novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.