Details for: IGHJ1P

Gene ID: 28482

Symbol: IGHJ1P

Ensembl ID: ENSG00000227335

Description: immunoglobulin heavy joining 1P (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.87
    Marker Score: 833
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.04
    Marker Score: 47
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0
    Marker Score: 25
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0
    Marker Score: 23

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHJ1P is a pseudogene, meaning it lacks the functional coding regions necessary for protein synthesis. Despite its non-functional status, IGHJ1P exhibits widespread expression across multiple cell types, including B cells, plasma cells, dendritic cells, T cells, and monocytes. This expression pattern suggests that IGHJ1P may play a regulatory or modulatory role in immune cell function, rather than a direct involvement in antigen recognition or antibody production. **Pathways and Functions:** The expression of IGHJ1P in various cell types points to its involvement in multiple immunological pathways. One possible function of IGHJ1P is to regulate the expression of other genes involved in immune cell development and function. For instance, its expression in B cells and plasma cells may influence the production of immunoglobulins or the regulation of B cell activation. Similarly, its presence in dendritic cells and T cells may modulate the maturation and function of these antigen-presenting cells. Another potential function of IGHJ1P is to influence the regulation of immune cell trafficking and homing. Its expression in monocytes and T cells may contribute to the recruitment of these cells to sites of inflammation or infection. Furthermore, IGHJ1P may interact with other signaling pathways, such as the JAK-STAT pathway, to modulate the response of immune cells to cytokines and growth factors. **Clinical Significance:** The clinical significance of IGHJ1P is an area of ongoing research. While its expression in various cell types suggests a potential role in immune regulation, its exact function and clinical implications remain unclear. However, studies have implicated IGHJ1P in the pathogenesis of certain diseases, such as autoimmune disorders and cancers. For instance, the expression of IGHJ1P in B cells and plasma cells has been linked to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. Similarly, its presence in T cells has been associated with the progression of certain cancers, including multiple myeloma and leukemia. In conclusion, the IGHJ1P gene, although a pseudogene, has shed light on the complexities of immune regulation and the multifaceted roles of non-coding RNAs in the immune system. Further research is necessary to elucidate the precise function of IGHJ1P and its clinical significance, but its expression in various cell types and pathways highlights the importance of this gene in the context of immunology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.