Details for: IGKV2D 19

Gene ID: 28887

Symbol: IGKV2D 19

Ensembl ID: ENSG00000253765

Description: immunoglobulin kappa variable 2D-19 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Unknown (CL0000003)
    Fold Change: 33.44
    Marker Score: 103,368
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 15.95
    Marker Score: 161,695
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.21
    Marker Score: 52,925
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.7
    Marker Score: 8,287
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.7
    Marker Score: 3,157
  • Cell Name: mast cell (CL0000097)
    Fold Change: 5.49
    Marker Score: 3,184
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 5.38
    Marker Score: 2,784
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 4.87
    Marker Score: 2,905
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6,853
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3,185
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 2.85
    Marker Score: 3,183
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.72
    Marker Score: 3,185
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71,564

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2D 19 is a member of the immunoglobulin kappa variable (IGKV) gene family, which plays a crucial role in the development and function of the immune system. As a pseudogene, IGKV2D 19 lacks the typical structure and function of functional immunoglobulin genes. However, its expression in various cell types suggests that it may have evolved to perform alternative functions or interact with other genes in a manner that is distinct from traditional immunoglobulin genes. **Pathways and Functions:** The expression of IGKV2D 19 in different cell types has led researchers to propose several possible functions for this pseudogene. Some potential pathways and functions of IGKV2D 19 include: 1. **Regulation of cell growth and differentiation**: IGKV2D 19 may play a role in regulating cell growth and differentiation in various cell types, including neurons and progenitor cells. 2. **Modulation of immune responses**: Although IGKV2D 19 is a pseudogene, it may still interact with other immune-related genes to modulate immune responses or influence the development of immune cells. 3. **Cytokine signaling**: IGKV2D 19 may be involved in cytokine signaling pathways, which are critical for the regulation of immune responses and inflammation. **Clinical Significance:** The clinical significance of IGKV2D 19 is an area of active research, and several potential implications have been proposed: 1. **Neurological disorders**: The expression of IGKV2D 19 in neurons and other brain cells has led researchers to speculate about its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Cancer**: IGKV2D 19 may be involved in the regulation of cell growth and differentiation in cancer cells, which could have implications for cancer therapy. 3. **Immune system dysregulation**: The expression of IGKV2D 19 in immune cells has led researchers to consider its potential role in immune system dysregulation, which could contribute to autoimmune diseases or other conditions. In conclusion, the IGKV2D 19 gene is a complex and enigmatic pseudogene that has sparked significant interest among researchers due to its widespread expression in various cell types. Further study of this gene is necessary to fully understand its functional significance and potential implications in human health and disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.