Details for: IGKV1D 22

Gene ID: 28899

Symbol: IGKV1D 22

Ensembl ID: ENSG00000253365

Description: immunoglobulin kappa variable 1D-22 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.0119
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0002
    Cell Significance Index: -0.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0015
    Cell Significance Index: -0.1000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0042
    Cell Significance Index: -0.0500
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0056
    Cell Significance Index: -0.0700
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0074
    Cell Significance Index: -0.0800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0156
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Pseudogene status:** IGKV1D 22 is classified as a pseudogene, meaning it has lost its functional ability to produce a protein, likely due to mutations or deletions. 2. **Wide expression:** This gene is expressed in multiple cell types, including those involved in the immune system (plasma cells, IgA plasma cells) and those outside the immune system (stromal cells, VIP GABAergic cortical interneurons, neurons). 3. **Lack of functional annotation:** Despite its expression in various cell types, IGKV1D 22 has not been annotated with a functional role, leading to its classification as a pseudogene. 4. **Evolutionary conservation:** IGKV1D 22 is conserved across species, suggesting that it may have had a functional role in the past, although its current function is unclear. **Pathways and Functions:** The exact function of IGKV1D 22 remains unknown, but several hypotheses have been proposed based on its expression patterns: 1. **Regulation of immune response:** IGKV1D 22 may play a role in regulating the immune response, particularly in plasma cells and IgA plasma cells, where it is co-expressed with other genes involved in antibody production. 2. **Cell signaling:** This gene may be involved in cell signaling pathways, particularly in VIP GABAergic cortical interneurons, where it is co-expressed with genes involved in neurotransmission. 3. **Stem cell maintenance:** IGKV1D 22 may contribute to the maintenance of stem cells, particularly small pre-B-II cells, where it is co-expressed with genes involved in cell proliferation and differentiation. 4. **Non-immune functions:** IGKV1D 22 may have non-immune functions, such as regulating gene expression or participating in cellular processes unrelated to the immune system. **Clinical Significance:** The expression of IGKV1D 22 in various cell types has significant implications for our understanding of human disease: 1. **Immunological disorders:** IGKV1D 22 may play a role in immunological disorders, such as autoimmune diseases or immunodeficiency syndromes, where its expression is altered. 2. **Neurological disorders:** The expression of IGKV1D 22 in VIP GABAergic cortical interneurons may contribute to neurological disorders, such as epilepsy or schizophrenia, where there is dysfunction in GABAergic neurotransmission. 3. **Cancer:** IGKV1D 22 may be involved in cancer development or progression, particularly in tumors with altered immune responses or stem cell-like properties. 4. **Gene therapy:** Understanding the function of IGKV1D 22 may lead to the development of novel gene therapies for various diseases, where its expression can be targeted to modulate immune responses or cellular processes. In conclusion, the IGKV1D 22 gene is a puzzling pseudogene with surprising expression patterns, challenging our understanding of gene function and regulation. Further research is needed to unravel its functional role and its implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.