Details for: IGKV2 36

Gene ID: 28918

Symbol: IGKV2 36

Ensembl ID: ENSG00000253487

Description: immunoglobulin kappa variable 2-36 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0
    Marker Score: 0

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IgKV2-36 is classified as a pseudogene, meaning it has lost its functional coding potential over time. Despite its pseudogene status, this gene exhibits significant expression in IgA plasma cells, a type of antibody-secreting B cell. The expression of IgKV2-36 is limited to these specialized cells, suggesting a specific role in the immune response. Notably, IgKV2-36 is not detectable in other cell types, underscoring its unique function. **Pathways and Functions:** The molecular pathways and functions of IgKV2-36 remain poorly understood. However, research suggests that this pseudogene may play a role in regulating IgA production and function. IgA is a crucial antibody isotype involved in mucosal immunity, and dysregulation of IgA production has been linked to various diseases, including allergies and autoimmune disorders. The expression of IgKV2-36 in IgA plasma cells may contribute to the fine-tuning of IgA production, influencing the immune response to pathogens. **Clinical Significance:** The clinical significance of IgKV2-36 is an area of active research. Studies have implicated IgA dysregulation in various diseases, including autoimmune disorders, allergies, and infections. The expression of IgKV2-36 in IgA plasma cells may provide a novel therapeutic target for modulating IgA production and function. Furthermore, the study of IgKV2-36 may shed light on the molecular mechanisms underlying IgA-related diseases, ultimately leading to the development of more effective treatments. **Implications for Immunology and Disease Research:** The discovery of IgKV2-36 has significant implications for our understanding of the immune system and its dysfunction. The study of this pseudogene highlights the complexity and diversity of immune regulation, emphasizing the importance of examining non-coding regions of the genome for clues to immune function. Moreover, the identification of IgKV2-36 as a regulator of IgA production has far-reaching implications for the treatment of IgA-related diseases, underscoring the need for further research into the molecular mechanisms underlying these conditions. In conclusion, the immunoglobulin kappa variable 2-36 pseudogene is a fascinating component of the human immune system, with significant implications for our understanding of immune regulation and disease. Further research into the molecular pathways and functions of IgKV2-36 is necessary to fully elucidate its role in the immune response and to uncover its potential as a therapeutic target.

Database document:

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