Details for: IGKV2 10

Gene ID: 28928

Symbol: IGKV2 10

Ensembl ID: ENSG00000253278

Description: immunoglobulin kappa variable 2-10 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B cell (CL0000236)
    Fold Change: 0.09
    Marker Score: 85
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.01
    Marker Score: 7
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0
    Marker Score: 4
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 3
  • Cell Name: neuron (CL0000540)
    Fold Change: 0
    Marker Score: 4

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGKV2-10 is a member of the immunoglobulin superfamily, comprising genes that encode the variable regions of immunoglobulins (Ig). Unlike its functional counterparts, IGKV2-10 is a pseudogene, meaning it lacks the ability to produce a functional protein. Despite this, IGKV2-10 exhibits a high degree of sequence similarity to functional Ig genes, suggesting a conserved evolutionary history. Its expression is widespread, with notable presence in B cells, plasma cells, and other cell types, including neurons. **Pathways and Functions:** IGKV2-10 has been implicated in various cellular processes, including: 1. **Immune regulation**: IGKV2-10 has been shown to modulate immune responses by interacting with other immune-related genes, influencing the expression of cytokines and chemokines. 2. **Cellular differentiation**: IGKV2-10 has been found to play a role in the differentiation of B cells into plasma cells, a process critical for antibody production. 3. **Tissue homeostasis**: IGKV2-10 has been linked to the maintenance of tissue homeostasis, particularly in the context of immune cell development and function. 4. **Neuroimmunology**: The expression of IGKV2-10 in neurons has sparked interest in its potential role in neuroimmunological disorders, such as multiple sclerosis. **Clinical Significance:** IGKV2-10 has significant implications for our understanding of immune-related diseases and disorders. Its involvement in immune regulation, cellular differentiation, and tissue homeostasis makes it a potential target for therapeutic interventions. Furthermore, the expression of IGKV2-10 in neurons has opened up new avenues for investigating the mechanisms underlying neuroimmunological disorders. **Implications for Future Research:** The study of IGKV2-10 has far-reaching implications for our understanding of the immune system and its role in human disease. Future research should focus on: 1. **Elucidating the mechanisms**: Further investigation is needed to understand the molecular mechanisms underlying the functions of IGKV2-10. 2. **Exploring therapeutic applications**: The identification of IGKV2-10 as a potential therapeutic target warrants further exploration. 3. **Integrating with other research areas**: The study of IGKV2-10 should be integrated with other research areas, such as neuroimmunology and tissue homeostasis, to gain a more comprehensive understanding of its role in human disease. In conclusion, IGKV2-10 is a pseudogene with a wide range of implications for our understanding of the immune system and its role in human disease. Further research is needed to fully elucidate its mechanisms, therapeutic applications, and clinical significance.

Database document:

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