Details for: IFNWP19

Gene ID: 3474

Symbol: IFNWP19

Ensembl ID: ENSG00000238271

Description: interferon omega 1 pseudogene 19

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0000
    Cell Significance Index: 0.0700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0017
    Cell Significance Index: -0.0400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0019
    Cell Significance Index: -0.0600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0024
    Cell Significance Index: -0.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0027
    Cell Significance Index: -0.0600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0037
    Cell Significance Index: -0.0400
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0069
    Cell Significance Index: -0.0800
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0098
    Cell Significance Index: -0.1200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0130
    Cell Significance Index: -0.1200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0161
    Cell Significance Index: -0.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFNWP19, a pseudogene, is a non-functional copy of the interferon omega 1 (IFNW1) gene. Unlike its functional counterpart, IFNW1, which plays a crucial role in the immune system, IFNWP19 lacks the ability to produce a functional protein. Despite this, IFNWP19 is expressed in various cell types, including bladder urothelial cells, lung goblet cells, respiratory basal cells, basal cells, astrocytes, stromal cells, and neurons. This widespread expression suggests that IFNWP19 may have evolved to perform alternative functions or interact with other genes to modulate cellular processes. **Pathways and Functions:** While IFNWP19 is a pseudogene, its expression in different cell types implies that it may be involved in various biological pathways. One possible explanation is that IFNWP19 acts as a decoy or competitor for the functional IFNW1 protein, thereby modulating its activity or expression levels. For instance, in bladder urothelial cells, IFNWP19 may interact with IFNW1 to regulate inflammation or immune responses. In lung goblet cells, IFNWP19 could influence the production of mucus or airway surface liquid, highlighting its potential role in respiratory diseases. Another possibility is that IFNWP19 participates in non-immune related processes, such as cell growth, differentiation, or survival. Its expression in astrocytes and neurons suggests that IFNWP19 may be involved in the regulation of glial or neuronal functions, potentially impacting neurological disorders. **Clinical Significance:** The clinical significance of IFNWP19 is an area of ongoing research. Given its widespread expression, IFNWP19 may serve as a biomarker for various diseases, including cancer, inflammatory disorders, or neurological conditions. For instance, its expression in bladder urothelial cells could be linked to bladder cancer, while its presence in lung goblet cells might be associated with chronic obstructive pulmonary disease (COPD). Furthermore, IFNWP19's potential role in modulating immune responses makes it an attractive target for the development of novel immunotherapies. By understanding the mechanisms by which IFNWP19 interacts with its functional counterpart, researchers may uncover new strategies for treating diseases characterized by dysregulated immune responses. In conclusion, IFNWP19, a pseudogenic gene with widespread expression, offers a fascinating glimpse into the complex interplay between gene expression and cellular processes. Further research is necessary to fully elucidate the functions and clinical significance of IFNWP19, but its intriguing expression profile suggests that it may hold the key to understanding various biological processes and developing novel therapeutic approaches.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.