Details for: ZNF773

Gene ID: 374928

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ZNF773

Ensembl ID: ENSG00000152439

Description: zinc finger protein 773

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 2.51
    rCSI 4.44%
    PRS 99.9

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ZNF773](/details-gene/374928) (Zinc Finger Protein 773) is a protein-coding gene located on chromosome 19q13.43 ([Link](https://doi.org/10.1038/nature02399)). Based on its functional annotations, [ZNF773](/details-gene/374928) is predicted to function as a nuclear, sequence-specific DNA-binding transcription factor. It likely participates in the regulation of gene expression through its interaction with RNA polymerase II. **Overall**, expression data indicates a highly specialized role for this gene, with significant expression almost exclusively observed in [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064), suggesting a potential function in the development or maintenance of this specific neuronal cell type. ## Cellular Roles and Expression Landscape The expression profile of [ZNF773](/details-gene/374928) points towards a highly specific cellular function rather than a broad role. - **Neuronal Specificity:** The most significant expression is found in [caudal ganglionic eminence derived cortical interneuron](/details-cell/CL4023064) (CSI: 2.51). The caudal ganglionic eminence (CGE) is a transient embryonic structure that gives rise to a significant portion of cortical GABAergic interneurons. The specific enrichment of [ZNF773](/details-gene/374928) in this lineage suggests it may be a key transcriptional regulator involved in the specification, migration, or functional maturation of these inhibitory neurons. - **Contextual Role:** The available data is limited to a general, **Overall** context, which highlights its role as a potential identity marker for this interneuron subtype. Further studies in developmental and disease contexts are required to understand if its significance is dynamic or stable. ## Pathways and Molecular Function The predicted molecular functions of [ZNF773](/details-gene/374928) are consistent with its role as a transcriptional regulator, which aligns with its specific expression in a developing neuronal population. - **Transcriptional Regulation:** Gene Ontology annotations place [ZNF773](/details-gene/374928) within the [nucleus](/details-go/GO:0005634), where it is involved in the [Regulation of transcription by rna polymerase ii](/details-go/GO:0006357). Its molecular function is defined as [Dna-binding transcription factor activity, rna polymerase ii-specific](/details-go/GO:0000981) and [Rna polymerase ii cis-regulatory region sequence-specific dna binding](/details-go/GO:0000978). This is further supported by its annotation in Reactome pathways such as [Gene expression (transcription)](https://reactome.org/content/detail/R-HSA-74160) and [Rna polymerase ii transcription](https://reactome.org/content/detail/R-HSA-73857). - **Structural Features:** As its name implies, it is a zinc finger protein, consistent with the [Metal ion binding](/details-go/GO:0046872) GO term. This structural motif is critical for its ability to bind DNA in a sequence-specific manner, thereby controlling the expression of target genes essential for interneuron identity and function. ## Research Directions The highly specific expression of [ZNF773](/details-gene/374928) in a distinct neuronal lineage, coupled with its presumed role as a transcription factor, opens several avenues for future investigation. **Proposed Hypotheses:** 1. **A Role in Neurodevelopment:** [ZNF773](/details-gene/374928) is a critical determinant for the fate specification or migratory guidance of interneuron precursors originating from the caudal ganglionic eminence. Its expression may be transiently required during a specific developmental window to establish the correct circuitry. 2. **Maintaining Neuronal Identity:** In the mature brain, [ZNF773](/details-gene/374928) may function as a terminal selector gene, continuously required to maintain the unique transcriptional program and physiological properties of CGE-derived interneurons. Its loss in adulthood could lead to neuronal dysfunction or even cell death. **Experimental Approach:** To test the hypothesis that [ZNF773](/details-gene/374928) is essential for the development of CGE-derived interneurons, a loss-of-function study in a mouse model would be highly informative. Using *in utero* electroporation, a CRISPR-Cas9 system targeting *ZNF773* could be specifically delivered to progenitor cells in the CGE of embryonic mice. Postnatal analysis of the targeted brain regions using single-cell RNA sequencing would reveal changes in cell fate and transcriptional identity, while immunohistochemistry for interneuron markers (e.g., reelin, calretinin) and electrophysiological recordings would assess the consequences on neuronal migration, integration, and function. **Therapeutic Potential:** Given its highly restricted expression, [ZNF773](/details-gene/374928) is unlikely to be a conventional therapeutic target for widespread neurological diseases. However, if pathogenic variants in [ZNF773](/details-gene/374928) are identified as causative for neurodevelopmental disorders associated with interneuronopathy, such as specific forms of epilepsy or schizophrenia, it could serve as a valuable diagnostic marker. Therapeutic intervention would be challenging, but targeted gene therapy to restore its function in affected neuronal precursors, rather than systemic inhibition or activation, might represent a theoretical long-term strategy.

Genular Protein ID: 71595455

Symbol: ZN773_HUMAN

Name: Zinc finger protein 773

UniProtKB Accession Codes:

Q6PK81 Q96DL8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 442
  • Mass: 50502
  • Checksum: 0CBC2E4427C3A01D
  • Sequence:
    • MAAATLRDPA QQGYVTFEDV AVYFSQEEWR LLDDAQRLLY RNVMLENFTL LASLGLASSK 
THEITQLESW EEPFMPAWEV VTSAILRGSW QGAKAEAAAE QSASVEVPSS NVQQHQKQHC 
GEKPLKRQEG RVPVLRSCRV HLSEKSLQSR EVGKDLLTSS GVLKHQVTHT GEKSHRSSKS 
REAFHAGKRH YKCSECGKAF GQKYLLVQHQ RLHTGEKPYE CSECGKLFSH KSNLFIHQIV 
HTGERPYGCS DCGKSFSRNA DLIQHQRVHT GEKPFTCSEC GKAFRHNSTL VQHHRIHTGV 
RPYECSECGK LFSFNSSLMK HQRVHTGERP YKCSECGKFY SHKSSLINHW RVHTGERPYE 
CSECGKFFSQ SSSLMQHRKV HTGEKPFKCN ECGRFFSENS SLVKHQRVHT GAKPYECREC 
GKFFRHSSSL VKHRRIHTGE IQ

Genular Protein ID: 1074448888

Symbol: M0QYZ8_HUMAN

Name: N/A

UniProtKB Accession Codes:

M0QYZ8

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 2 Pfam 1 Proteomes 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 101
  • Mass: 11569
  • Checksum: F6C6786C41D2A322
  • Sequence:
    • MAAATLRDPA QGYVTFEDVA VYFSQEEWRL LDDAQRLLYR NVMLENFTLL ASLGLASSKT 
HEITQLESWE EPFMPAWEVV TSAILRVPNR QPQVAPEQGR E