Details for: MIR100

Gene ID: 406892

Symbol: MIR100

Ensembl ID: ENSG00000207994

Description: microRNA 100

Associated with

  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Mirna-mediated gene silencing by inhibition of translation
    (GO:0035278)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of interleukin-8 production
    (GO:0032717)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of vascular associated smooth muscle cell differentiation
    (GO:1905064)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR100 is a 22-nucleotide long, single-stranded RNA molecule that belongs to the microRNA family. It is highly expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, pericytes, and cardiac endothelial cells. MIR100 is known to regulate gene expression through two main mechanisms: inhibiting translation and destabilizing mRNA. Its binding to target mRNAs can lead to the suppression of gene expression, thereby modulating cellular processes. **Pathways and Functions:** MIR100 is involved in several important signaling pathways, including: 1. **Negative regulation of BMP signaling pathway**: MIR100 has been shown to inhibit the BMP (Bone Morphogenetic Protein) signaling pathway, which is crucial for cell differentiation, proliferation, and development. 2. **Negative regulation of interleukin-8 production**: MIR100 modulates the production of interleukin-8 (IL-8), a pro-inflammatory cytokine involved in immune responses. 3. **Negative regulation of osteoblast differentiation**: MIR100 inhibits the differentiation of osteoblasts, which are essential for bone formation. 4. **Negative regulation of vascular associated smooth muscle cell differentiation**: MIR100 modulates the differentiation of vascular associated smooth muscle cells, which is critical for vascular development and function. 5. **RISC complex**: MIR100 interacts with the RISC (RNA-induced silencing complex) to regulate gene expression through mRNA degradation. **Clinical Significance:** MIR100 has been implicated in various disease states, including: 1. **Cardiovascular diseases**: MIR100 has been shown to play a role in the development of cardiovascular diseases, such as atherosclerosis and cardiac hypertrophy. 2. **Cancer**: MIR100 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it contributes to tumor progression and metastasis. 3. **Neurological disorders**: MIR100 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. In conclusion, MIR100 is a crucial regulator of gene expression and cellular processes, influencing various signaling pathways and disease states. Further research is needed to fully understand the mechanisms of MIR100 and its potential therapeutic applications in disease treatment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.