Details for: MIR153 2

Gene ID: 406945

Symbol: MIR153 2

Ensembl ID: ENSG00000207960

Description: microRNA 153-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0114
    Cell Significance Index: 0.2500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0060
    Cell Significance Index: -0.0800
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0079
    Cell Significance Index: -0.0900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0088
    Cell Significance Index: -0.0900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0095
    Cell Significance Index: -0.1100
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0145
    Cell Significance Index: -0.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR153-2 is a 22-nucleotide long non-coding RNA that belongs to the microRNA family. MicroRNAs are small, single-stranded RNAs that regulate gene expression by binding to the 3' untranslated region (UTR) of target mRNAs, leading to their degradation or inhibition of translation. MIR153-2 is predominantly expressed in cells of the immune system, particularly in lymphoid lineage-restricted progenitor cells and innate lymphoid cells. Its expression is also observed in cardiac cells, suggesting a role in cardiac development and function. **Pathways and Functions** MIR153-2 is involved in regulating several cellular pathways, including: 1. **Cell proliferation and differentiation**: MIR153-2 targets genes involved in cell growth and differentiation, such as cyclin D1 and CDK4, to regulate cellular proliferation and differentiation. 2. **Immune response**: MIR153-2 is expressed in lymphoid lineage-restricted progenitor cells and innate lymphoid cells, suggesting a role in regulating immune cell development and function. 3. **Cardiac development and function**: MIR153-2 is expressed in cardiac endothelial cells and cardiac muscle myoblasts, suggesting a role in regulating cardiac development and function. **Clinical Significance** The dysregulation of MIR153-2 has been implicated in various diseases, including: 1. **Cardiovascular disease**: MIR153-2 has been shown to play a role in regulating cardiac development and function, and its dysregulation may contribute to the development of cardiovascular disease. 2. **Immune disorders**: MIR153-2's role in regulating immune cell development and function suggests that its dysregulation may contribute to immune disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: MIR153-2 has been shown to target genes involved in cell growth and differentiation, and its dysregulation may contribute to the development of cancer. In conclusion, microRNA 153-2 is a small non-coding RNA that plays a crucial role in regulating cellular differentiation and immune response. Its dysregulation has been implicated in various diseases, including cardiovascular disease, immune disorders, and cancer. Further research is needed to fully understand the mechanisms by which MIR153-2 regulates cellular behavior and to explore its potential as a therapeutic target.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.