Details for: MIR185

Gene ID: 406961

Symbol: MIR185

Ensembl ID: ENSG00000208023

Description: microRNA 185

Associated with

  • Cellular response to cholesterol
    (GO:0071397)
  • Cholesterol homeostasis
    (GO:0042632)
  • Extracellular space
    (GO:0005615)
  • Extracellular vesicle
    (GO:1903561)
  • Lncrna binding
    (GO:0106222)
  • Mirna-mediated gene silencing by mrna destabilization
    (GO:0035279)
  • Mirna-mediated post-transcriptional gene silencing
    (GO:0035195)
  • Mrna 3'-utr binding
    (GO:0003730)
  • Mrna base-pairing translational repressor activity
    (GO:1903231)
  • Negative regulation of (r)-mevalonic acid biosynthetic process
    (GO:0106108)
  • Negative regulation of angiogenesis
    (GO:0016525)
  • Negative regulation of b cell activation
    (GO:0050869)
  • Negative regulation of b cell proliferation
    (GO:0030889)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of cholesterol biosynthetic process
    (GO:0045541)
  • Negative regulation of erk1 and erk2 cascade
    (GO:0070373)
  • Negative regulation of fatty acid biosynthetic process
    (GO:0045717)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of high-density lipoprotein particle clearance
    (GO:0010987)
  • Negative regulation of low-density lipoprotein particle clearance
    (GO:0010989)
  • Negative regulation of receptor-mediated endocytosis involved in cholesterol transport
    (GO:1905601)
  • Negative regulation of response to drug
    (GO:2001024)
  • Negative regulation of signal transduction
    (GO:0009968)
  • Negative regulation of transmembrane transport
    (GO:0034763)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Negative regulation of vascular associated smooth muscle cell proliferation
    (GO:1904706)
  • Negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
    (GO:1905700)
  • Positive regulation of macrophage derived foam cell differentiation
    (GO:0010744)
  • Risc complex
    (GO:0016442)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1143
    Cell Significance Index: 1.5700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0135
    Cell Significance Index: 0.3600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0040
    Cell Significance Index: -0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR185 is a microRNA, a class of small non-coding RNAs that regulate gene expression post-transcriptionally by binding to target messenger RNAs (mRNAs). MIR185 is expressed in various cell types, including neuronal receptor cells, smooth muscle myoblasts, lymphoid lineage-restricted progenitor cells, pericytes, cardiac muscle myoblasts, cardiac endothelial cells, immature innate lymphoid cells, and fibroblasts of cardiac tissue. Its expression is significantly regulated in response to cellular stress, inflammation, and developmental processes. **Pathways and Functions:** MIR185 participates in multiple signaling pathways, including: 1. **Cellular response to cholesterol**: MIR185 negatively regulates cholesterol biosynthesis, which is essential for maintaining cholesterol homeostasis and preventing atherosclerosis. 2. **Extracellular space**: MIR185 regulates the clearance of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles, which are crucial for lipid metabolism and cardiovascular health. 3. **Angiogenesis**: MIR185 negatively regulates angiogenesis, the process of new blood vessel formation, which is essential for tumor growth and metastasis. 4. **B cell activation and proliferation**: MIR185 negatively regulates B cell activation and proliferation, which are critical for immune responses. 5. **Cell migration and transmigration**: MIR185 regulates cell migration and transmigration, which are essential for immune cell trafficking and tissue repair. MIR185 also interacts with various transcription factors and signaling molecules, including the RISC complex, to regulate gene expression. Its dysregulation has been implicated in various diseases, including atherosclerosis, cancer, and autoimmune disorders. **Clinical Significance:** Dysregulation of MIR185 has been implicated in various diseases, including: 1. **Atherosclerosis**: MIR185 deficiency has been associated with increased cholesterol levels and atherosclerosis. 2. **Cancer**: MIR185 has been shown to suppress tumor growth and metastasis by regulating angiogenesis and immune responses. 3. **Autoimmune disorders**: MIR185 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, by regulating immune cell activation and proliferation. In conclusion, MIR185 is a critical regulator of immune response, metabolism, and cardiovascular health. Its dysregulation has significant clinical implications, and further research is needed to fully understand its role in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.