Details for: MIR7 2

Gene ID: 407044

Symbol: MIR7 2

Ensembl ID: ENSG00000207703

Description: microRNA 7-2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2872
    Cell Significance Index: 4.0300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.0738
    Cell Significance Index: 0.8100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0048
    Cell Significance Index: -0.0300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1593
    Cell Significance Index: -3.4900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2680
    Cell Significance Index: -3.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3265
    Cell Significance Index: -3.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MIR7-2 exhibits several key characteristics that distinguish it from other microRNAs: 1. **Sequence and structure**: MIR7-2 has a characteristic microRNA sequence and structure, consisting of a 5' untranslated region (5' UTR), a stem-loop region, and a 3' untranslated region (3' UTR). 2. **Target specificity**: MIR7-2 has been shown to target specific mRNAs, including those involved in cell differentiation, proliferation, and survival. 3. **Expression profile**: MIR7-2 is significantly expressed in various cell types, suggesting its involvement in regulating cellular differentiation and development. 4. **Regulatory pathways**: MIR7-2 is involved in regulating microRNA-mediated post-transcriptional gene silencing (miRNA-mediated silencing) and the RISC complex, which is a key component of the miRNA-mediated silencing pathway. **Pathways and Functions** MIR7-2 is involved in several key regulatory pathways, including: 1. **MicroRNA-mediated post-transcriptional gene silencing**: MIR7-2 regulates the expression of specific mRNAs by binding to their 3' UTRs, leading to degradation or repression of translation. 2. **RISC complex**: MIR7-2 is a component of the RISC complex, which is responsible for recognizing and binding to specific mRNAs, leading to their degradation or repression. 3. **Cell differentiation and development**: MIR7-2 regulates the expression of genes involved in cell differentiation and development, including those involved in the specification of enteroendocrine cells, neuronal receptor cells, and smooth muscle myoblasts. 4. **Immune responses**: MIR7-2 has been implicated in regulating immune responses, including the expression of genes involved in lymphoid lineage-restricted progenitor cell development. **Clinical Significance** MIR7-2 has significant clinical implications, particularly in the context of: 1. **Cancer**: MIR7-2 has been shown to be downregulated in various types of cancer, including colorectal cancer, suggesting its potential as a diagnostic biomarker. 2. **Regenerative medicine**: MIR7-2 has been implicated in regulating the expression of genes involved in cellular differentiation and development, suggesting its potential as a therapeutic agent in regenerative medicine. 3. **Immune system disorders**: MIR7-2 has been shown to regulate immune responses, suggesting its potential as a therapeutic agent in the treatment of immune system disorders, including autoimmune diseases. In conclusion, microRNA 7-2 (MIR7-2) is a small non-coding RNA that plays a critical role in regulating cellular differentiation, development, and immune responses. Its significant expression profile and regulatory pathways suggest its potential as a diagnostic biomarker, therapeutic agent, and therapeutic target for various diseases, including cancer, regenerative medicine, and immune system disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.