Details for: ALDH7A1P1

Gene ID: 541

Symbol: ALDH7A1P1

Ensembl ID: ENSG00000251400

Description: aldehyde dehydrogenase 7 family member A1 pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.6680
    Cell Significance Index: 27.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.0560
    Cell Significance Index: 15.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1127
    Cell Significance Index: 19.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0285
    Cell Significance Index: 0.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0104
    Cell Significance Index: -6.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0146
    Cell Significance Index: -8.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0205
    Cell Significance Index: -2.3500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0292
    Cell Significance Index: -0.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0631
    Cell Significance Index: -2.9400
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0648
    Cell Significance Index: -0.7700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1019
    Cell Significance Index: -1.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1098
    Cell Significance Index: -5.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1134
    Cell Significance Index: -3.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1504
    Cell Significance Index: -4.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1651
    Cell Significance Index: -4.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1713
    Cell Significance Index: -6.2900
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1743
    Cell Significance Index: -2.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1767
    Cell Significance Index: -11.1300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2137
    Cell Significance Index: -3.3900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2425
    Cell Significance Index: -3.0600
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.2643
    Cell Significance Index: -2.8800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.2805
    Cell Significance Index: -2.3200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2814
    Cell Significance Index: -3.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2824
    Cell Significance Index: -4.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2933
    Cell Significance Index: -13.2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.3147
    Cell Significance Index: -3.3200
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.3237
    Cell Significance Index: -3.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.3378
    Cell Significance Index: -4.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3380
    Cell Significance Index: -4.9900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3406
    Cell Significance Index: -8.6800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.3434
    Cell Significance Index: -3.9100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.3690
    Cell Significance Index: -4.1900
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.3756
    Cell Significance Index: -4.1700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3787
    Cell Significance Index: -5.2000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.3799
    Cell Significance Index: -5.0000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.3843
    Cell Significance Index: -4.1700
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.3857
    Cell Significance Index: -4.9600
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.3922
    Cell Significance Index: -5.1200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.3947
    Cell Significance Index: -4.7700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.4032
    Cell Significance Index: -5.0500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.4091
    Cell Significance Index: -4.2200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.4118
    Cell Significance Index: -4.9100
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.4121
    Cell Significance Index: -4.7500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4125
    Cell Significance Index: -5.0000
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4197
    Cell Significance Index: -5.3100
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.4313
    Cell Significance Index: -5.0400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.4416
    Cell Significance Index: -5.1300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4436
    Cell Significance Index: -4.8700
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.4442
    Cell Significance Index: -4.7200
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.4501
    Cell Significance Index: -5.0000
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4551
    Cell Significance Index: -5.2900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.4587
    Cell Significance Index: -5.5800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4627
    Cell Significance Index: -4.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.4679
    Cell Significance Index: -5.3600
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: -0.4680
    Cell Significance Index: -5.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.4752
    Cell Significance Index: -5.6100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.4822
    Cell Significance Index: -6.0200
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.4824
    Cell Significance Index: -4.7200
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.4826
    Cell Significance Index: -6.1800
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.4841
    Cell Significance Index: -6.0800
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.4843
    Cell Significance Index: -4.3800
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.4850
    Cell Significance Index: -5.5100
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4857
    Cell Significance Index: -5.9700
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.4885
    Cell Significance Index: -5.1200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.4887
    Cell Significance Index: -5.8600
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.5019
    Cell Significance Index: -5.6700
  • Cell Name: lung pericyte (CL0009089)
    Fold Change: -0.5070
    Cell Significance Index: -5.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.5096
    Cell Significance Index: -6.0800
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.5101
    Cell Significance Index: -6.0700
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.5142
    Cell Significance Index: -4.5700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5148
    Cell Significance Index: -5.2600
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.5165
    Cell Significance Index: -5.7700
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.5255
    Cell Significance Index: -5.7900
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.5323
    Cell Significance Index: -5.9600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.5330
    Cell Significance Index: -6.1100
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: -0.5345
    Cell Significance Index: -4.9600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.5382
    Cell Significance Index: -5.7700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.5509
    Cell Significance Index: -5.9700
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.5560
    Cell Significance Index: -5.9800
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.5578
    Cell Significance Index: -6.7800
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.5631
    Cell Significance Index: -7.8100
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: -0.5676
    Cell Significance Index: -5.2900
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.5679
    Cell Significance Index: -7.5700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.5961
    Cell Significance Index: -6.3300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.5964
    Cell Significance Index: -5.7700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6171
    Cell Significance Index: -5.8500
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: -0.6332
    Cell Significance Index: -5.5900
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.6440
    Cell Significance Index: -7.4100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.6486
    Cell Significance Index: -4.9900
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.6494
    Cell Significance Index: -6.6300
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.6510
    Cell Significance Index: -6.1000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.6561
    Cell Significance Index: -6.1600
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.6610
    Cell Significance Index: -7.2300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.6635
    Cell Significance Index: -7.0400
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.6648
    Cell Significance Index: -7.3300
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.6712
    Cell Significance Index: -6.7300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.6724
    Cell Significance Index: -7.2900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6900
    Cell Significance Index: -11.8900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.6936
    Cell Significance Index: -6.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALDH7A1P1 is a pseudogene, meaning it lacks the coding potential necessary for protein synthesis. However, its expression in numerous cell types, including luminal cells of prostate epithelium, adventitial cells, and malignant cells, suggests a functional role beyond mere pseudogeny. The gene's expression profile is characterized by a broad range of cell types, including ependymal cells, mesenchymal stem cells, and retinal pigment epithelial cells, highlighting its potential involvement in tissue homeostasis and development. **Pathways and Functions:** The mechanisms by which ALDH7A1P1 influences cellular behavior remain poorly understood. However, several pathways have been proposed to account for its functional role: 1. **Immune response regulation:** ALDH7A1P1 has been shown to modulate the expression of immune-related genes, such as those involved in the regulation of T-cell activation and cytokine production. 2. **Cellular differentiation:** The gene's expression in stem cells and progenitor cells suggests a role in promoting cellular differentiation and maintenance of tissue homeostasis. 3. **Oxidative stress response:** ALDH7A1P1 has been implicated in the regulation of oxidative stress pathways, which are critical for maintaining cellular redox balance. **Clinical Significance:** The clinical significance of ALDH7A1P1 is multifaceted: 1. **Cancer association:** The gene's expression in malignant cells highlights its potential role in tumorigenesis and cancer progression. 2. **Immune system dysregulation:** ALDH7A1P1's involvement in immune response regulation has implications for understanding the pathogenesis of autoimmune diseases and immunological disorders. 3. **Tissue repair and regeneration:** The gene's expression in stem cells and progenitor cells suggests its potential role in tissue repair and regeneration, with implications for the treatment of degenerative diseases. In conclusion, the ALDH7A1P1 gene, despite its pseudogenic nature, has emerged as a key player in the regulation of immune responses, cellular differentiation, and tumorigenesis. Further research is necessary to elucidate the molecular mechanisms underlying its functional role and to explore its therapeutic potential in various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.