CACTIN | ENSG00000105298 | NCBI 58509

Details for: CACTIN

Gene ID: 58509

Symbol: CACTIN

Ensembl ID: ENSG00000105298

Description: cactin, spliceosome C complex subunit

Associated with

Metabolism of rna
(R-HSA-8953854)
Mrna splicing
(R-HSA-72172)
Mrna splicing - major pathway
(R-HSA-72163)
Processing of capped intron-containing pre-mrna
(R-HSA-72203)
Catalytic step 2 spliceosome
(GO:0071013)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Innate immune response
(GO:0045087)
Mrna cis splicing, via spliceosome
(GO:0045292)
Mrna splicing, via spliceosome
(GO:0000398)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of interferon-beta production
(GO:0032688)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of lipopolysaccharide-mediated signaling pathway
(GO:0031665)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Negative regulation of type i interferon-mediated signaling pathway
(GO:0060339)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Spliceosomal complex
(GO:0005681)

Other Information

Proteins

Renal carcinoma antigen NY-REN-24

Genular Protein ID: 3057607159

Symbol: CATIN_HUMAN

Name: Renal carcinoma antigen NY-REN-24

UniProtKB Accession Codes:

Q8WUQ7 A6NNA9 A9UL12 O75229 Q7LE08 Q9BTA6 Q9Y5A4

Database IDs:

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508479

Title: Antigens recognized by autologous antibody in patients with renal-cell carcinoma.

PubMed ID: 10508479

DOI: 10.1002/(sici)1097-0215(19991112)83:4<456::aid-ijc4>3.0.co;2-5

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 20829348

Title: Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways.

PubMed ID: 20829348

DOI: 10.1074/jbc.m110.139113

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26363554

Title: TRIM39 negatively regulates the NFkappaB-mediated signaling pathway through stabilization of Cactin.

PubMed ID: 26363554

DOI: 10.1007/s00018-015-2040-x

PubMed ID: 28062851

Title: Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion.

PubMed ID: 28062851

DOI: 10.1242/jcs.194068

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34365507

Title: SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.

PubMed ID: 34365507

DOI: 10.1093/nar/gkab647

Sequence Information:

Length: 758
Mass: 88702
Checksum: F540F151EB96BEFB
Sequence:

MGRDTRSRSR SAGRRGRRRQ SQSGSRSRSR SHGRRNRRRR EDEGRRRRRR RSRERRSDSE 
EERWQRSGMR SRSPPRPKWH SRDGSSQSDS GEEQSRGQWA RRRRRARSWS PSSSASSSAS 
PGRSQSPRAA AAALSQQQSL QERLRLREER KQQEELMKAF ETPEEKRARR LAKKEAKERK 
KREKMGWGEE YMGYTNTDNP FGDNNLLGTF IWNKALEKKG ISHLEEKELK ERNKRIQEDN 
RLELQKVKQL RLEREREKAM REQELEMLQR EKEAEHFKTW EEQEDNFHLQ QAKLRSKIRI 
RDGRAKPIDL LAKYISAEDD DLAVEMHEPY TFLNGLTVAD MEDLLEDIQV YMELEQGKNA 
DFWRDMTTIT EDEISKLRKL EASGKGPGER REGVNASVSS DVQSVFKGKT YNQLQVIFQG 
IEGKIRAGGP NLDMGYWESL LQQLRAHMAR ARLRERHQDV LRQKLYKLKQ EQGVESEPLF 
PILKQEPQSP SRSLEPEDAA PTPPGPSSEG GPAEAEVDGA TPTEGDGDGD GEGEGEGEAV 
LMEEDLIQQS LDDYDAGRYS PRLLTAHELP LDAHVLEPDE DLQRLQLSRQ QLQVTGDASE 
SAEDIFFRRA KEGMGQDEAQ FSVEMPLTGK AYLWADKYRP RKPRFFNRVH TGFEWNKYNQ 
THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA DNKDFAILRF HAGPPYEDIA 
FKIVNREWEY SHRHGFRCQF ANGIFQLWFH FKRYRYRR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CACTIN

Associated with

Other Information

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antigens recognized by autologous antibody in patients with renal-cell carcinoma. PubMed ID: 10508479

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. PubMed ID: 11991638

Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways. PubMed ID: 20829348

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

TRIM39 negatively regulates the NFkappaB-mediated signaling pathway through stabilization of Cactin. PubMed ID: 26363554

Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and sister chromatid cohesion. PubMed ID: 28062851

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. PubMed ID: 34365507