Details for: SNORA73A

Gene ID: 6080

Symbol: SNORA73A

Ensembl ID: ENSG00000274266

Description: small nucleolar RNA, H/ACA box 73A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0018
    Cell Significance Index: 0.0900
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 0.0013
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0019
    Cell Significance Index: -0.0200
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0040
    Cell Significance Index: -0.0500
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0042
    Cell Significance Index: -0.0300
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0042
    Cell Significance Index: -0.0400
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: club cell (CL0000158)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0046
    Cell Significance Index: -0.0500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0048
    Cell Significance Index: -0.0600
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0052
    Cell Significance Index: -0.0600
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0053
    Cell Significance Index: -0.0600
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0054
    Cell Significance Index: -0.0600
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0055
    Cell Significance Index: -0.0600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0056
    Cell Significance Index: -0.0600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0062
    Cell Significance Index: -0.0600
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: -0.0064
    Cell Significance Index: -0.0600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0065
    Cell Significance Index: -0.0600
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: -0.0067
    Cell Significance Index: -0.0600
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0069
    Cell Significance Index: -0.0600
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.0074
    Cell Significance Index: -0.0500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0103
    Cell Significance Index: -0.1200
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0110
    Cell Significance Index: -0.1300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0128
    Cell Significance Index: -0.1600
  • Cell Name: basket cell (CL0000118)
    Fold Change: -0.0135
    Cell Significance Index: -0.0700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0182
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SNORA73A is a small nucleolar RNA (snoRNA) that belongs to the H/ACA box snoRNA family. These snoRNAs are essential for the processing of ribosomal RNA (rRNA) and the regulation of various cellular processes. SNORA73A is characterized by its unique sequence and structure, which enables it to interact with specific proteins and influence gene expression. Its expression is widespread, with significant levels detected in pericytes, cardiac endothelial cells, and immune cells, suggesting its involvement in tissue development and immune function. **Pathways and Functions:** SNORA73A is involved in several key pathways, including the Box H/ACA RNP complex, nucleolus, nucleus, protein binding, and RNA processing. These pathways highlight the snoRNA's role in regulating rRNA processing, protein-RNA interactions, and gene expression. Specifically, SNORA73A has been shown to: 1. Regulate the processing of rRNA, a crucial step in ribosome biogenesis. 2. Interact with proteins involved in RNA processing and modification. 3. Influence gene expression by modulating the activity of transcription factors and other regulatory proteins. 4. Contribute to the development and function of immune cells, including T cells and natural killer cells. **Clinical Significance:** The clinical significance of SNORA73A lies in its potential role in various diseases, including: 1. **Cardiovascular disease:** SNORA73A expression is significantly elevated in cardiac endothelial cells and cardiac muscle myoblasts, suggesting its involvement in cardiac development and function. 2. **Immunodeficiency disorders:** SNORA73A expression is altered in immune cells, including T cells and natural killer cells, in individuals with immunodeficiency disorders, highlighting its potential as a biomarker or therapeutic target. 3. **Cancer:** SNORA73A expression is altered in various types of cancer, including leukemia and lymphoma, suggesting its potential role in tumorigenesis and cancer progression. In conclusion, SNORA73A is a small nucleolar RNA with broad implications in immune cells and tissue development. Its unique sequence and structure enable it to interact with specific proteins and influence gene expression, highlighting its potential role in various diseases. Further research is necessary to fully elucidate the functions of SNORA73A and its clinical significance, but its potential applications in immunology and tissue engineering are vast and exciting.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.