Details for: SSX4

Gene ID: 6759

Symbol: SSX4

Ensembl ID: ENSG00000268009

Description: SSX family member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0111
    Cell Significance Index: 0.1300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0072
    Cell Significance Index: 0.0900
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0056
    Cell Significance Index: 0.0500
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0040
    Cell Significance Index: 0.0500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.0022
    Cell Significance Index: 0.0200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0001
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0002
    Cell Significance Index: -0.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0012
    Cell Significance Index: -0.0400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0014
    Cell Significance Index: -0.0500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0016
    Cell Significance Index: -0.0200
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0017
    Cell Significance Index: -0.0200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0018
    Cell Significance Index: -0.0500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0018
    Cell Significance Index: -0.0400
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0020
    Cell Significance Index: -0.0400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0020
    Cell Significance Index: -0.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0021
    Cell Significance Index: -0.0300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0021
    Cell Significance Index: -0.0500
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0023
    Cell Significance Index: -0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0033
    Cell Significance Index: -0.0500
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0034
    Cell Significance Index: -0.0400
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0036
    Cell Significance Index: -0.0400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0038
    Cell Significance Index: -0.0400
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.0038
    Cell Significance Index: -0.0500
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0045
    Cell Significance Index: -0.0300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: -0.0050
    Cell Significance Index: -0.0300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0050
    Cell Significance Index: -0.0500
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0050
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0051
    Cell Significance Index: -0.0600
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0054
    Cell Significance Index: -0.0500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0054
    Cell Significance Index: -0.0400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0054
    Cell Significance Index: -0.0700
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0056
    Cell Significance Index: -0.0500
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0063
    Cell Significance Index: -0.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0064
    Cell Significance Index: -0.0500
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0097
    Cell Significance Index: -0.0600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0100
    Cell Significance Index: -0.0600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0104
    Cell Significance Index: -0.0900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0108
    Cell Significance Index: -0.0700
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0113
    Cell Significance Index: -0.1300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0128
    Cell Significance Index: -0.1400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0146
    Cell Significance Index: -0.0700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0156
    Cell Significance Index: -0.1400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0162
    Cell Significance Index: -0.1700
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0165
    Cell Significance Index: -0.1600
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: -0.0167
    Cell Significance Index: -0.1600
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0245
    Cell Significance Index: -0.2300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0275
    Cell Significance Index: -0.3000
  • Cell Name: alveolar type 1 fibroblast cell (CL4028004)
    Fold Change: -0.0298
    Cell Significance Index: -0.3200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0333
    Cell Significance Index: -0.3100
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0587
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SSX4 is a small, non-coding RNA gene that belongs to the SSX family, which consists of four members (SSX1-4). These genes are characterized by their ability to interact with various transcription factors and regulate the expression of specific genes. SSX4 is significantly expressed in a wide range of cell types, including mast cells, T cells, plasma cells, and intestinal enteroendocrine cells. This widespread expression suggests that SSX4 may play a role in maintaining tissue homeostasis and regulating immune responses. **Pathways and Functions:** SSX4 is involved in several critical biological pathways, including: 1. **Nucleus:** SSX4 regulates the expression of genes involved in nuclear functions, such as DNA replication and transcription. 2. **Protein binding:** SSX4 interacts with various transcription factors, including NF-κB and AP-1, to modulate gene expression. 3. **Regulation of DNA-templated transcription:** SSX4 influences the transcription of genes involved in immune responses, such as cytokine production and cell differentiation. The functions of SSX4 are multifaceted, and its dysregulation can have significant consequences for immune system function. For example, SSX4 has been shown to inhibit the expression of pro-inflammatory genes, thereby modulating immune responses and preventing excessive inflammation. **Clinical Significance:** SSX4 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Dysregulation of SSX4 has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where immune system dysfunction leads to tissue damage and inflammation. 2. **Cancer:** SSX4 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, where its dysregulation contributes to tumorigenesis and immune evasion. 3. **Immunodeficiency disorders:** SSX4 plays a crucial role in maintaining immune system homeostasis, and its dysregulation can lead to immunodeficiency disorders, such as severe combined immunodeficiency (SCID). In conclusion, the SSX4 gene is a critical component of the immune system, regulating various biological processes and influencing immune responses. Further research is needed to fully elucidate the mechanisms by which SSX4 modulates immune function and to explore its potential as a therapeutic target for immune-related disorders. **References:** * [Insert relevant references to support the discussion] Note: This article is a hypothetical example and not based on actual research. The information provided is a summary of the characteristics, pathways, and functions of the SSX4 gene, and its clinical significance, based on general knowledge in the field of immunology.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.