Gene CDY1 - ENSG00000172288 | NCBI Gene ID: 9085

Details for: CDY1

Gene ID: 9085

Symbol: CDY1

Ensembl ID: ENSG00000172288

Description: chromodomain Y-linked 1

Associated with

Chromatin remodeling
(GO:0006338)
Histone acetyltransferase activity
(GO:0004402)
Methylated histone binding
(GO:0035064)
Negative regulation of dna-templated transcription
(GO:0045892)
Nucleus
(GO:0005634)
Spermatogenesis
(GO:0007283)
Transcription corepressor activity
(GO:0003714)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: erythrocyte (CL0000232)
Fold Change: 6.39
Marker Score: 3539
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 2.75
Marker Score: 3798
Cell Name: megakaryocyte (CL0000556)
Fold Change: 2.53
Marker Score: 1437
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 2.27
Marker Score: 1221
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 2.15
Marker Score: 1131
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 1.58
Marker Score: 661
Cell Name: goblet cell (CL0000160)
Fold Change: 1.52
Marker Score: 10080
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.51
Marker Score: 1153
Cell Name: mast cell (CL0000097)
Fold Change: 1.31
Marker Score: 757
Cell Name: precursor B cell (CL0000817)
Fold Change: 1.19
Marker Score: 788
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.13
Marker Score: 6845
Cell Name: macrophage (CL0000235)
Fold Change: 1.12
Marker Score: 1242
Cell Name: abnormal cell (CL0001061)
Fold Change: 1.08
Marker Score: 3222
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 1.03
Marker Score: 825
Cell Name: absorptive cell (CL0000212)
Fold Change: 1.02
Marker Score: 31474
Cell Name: natural killer cell (CL0000623)
Fold Change: 0.98
Marker Score: 1269
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2386
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.83
Marker Score: 4749
Cell Name: brush cell (CL0002204)
Fold Change: 0.82
Marker Score: 745
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1269
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.51
Marker Score: 1269
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.37
Marker Score: 1268
Cell Name: progenitor cell (CL0011026)
Fold Change: 0.33
Marker Score: 2149
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.31
Marker Score: 1269

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Other Information

Description

**Key characteristics:** - CDY1 is a protein with a molecular weight of approximately 70-80 kDa. - It is a member of the chromodomain Y-family of chromatin remodelers. - CDY1 is found in the nucleus and cytoplasm of cells. - It is a key regulator of gene expression by modulating the accessibility of DNA to transcription factors. **Pathways and functions:** - CDY1 is involved in chromatin remodeling, which is the process of altering the structure of DNA to facilitate or repress transcription. - It is a key regulator of gene expression by controlling the accessibility of DNA to transcription factors. - In hematopoietic cells, CDY1 is essential for the development and maintenance of normal blood cell populations. - It is also involved in the development and maintenance of immune cells, including T cells and B cells. - In non-hematopoietic cells, CDY1 plays a role in cell cycle regulation, apoptosis, and differentiation. **Clinical significance:** - Mutations in CDY1 have been linked to several human diseases, including acute myeloid leukemia (AML), chronic myeloid leukemia (CML), and solid tumors. - In AML, mutations in CDY1 are often associated with the development of resistance to chemotherapy. - Targeting CDY1 has emerged as a potential therapeutic strategy for cancer treatment. **Additional information:** - CDY1 is a highly conserved gene with similar sequences in humans, mice, and rats. - It is also expressed in germ cells, suggesting a role in embryonic development. - CDY1 is a promising target for cancer immunotherapy due to its involvement in chromatin remodeling and tumor growth.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.