Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 134826889
{
"geneID": 134826889,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC027088.8"
]
},
"genePos": {
"start": 68930525,
"end": 69062762
},
"orientation": false,
"symbol": "SPESP1 NOX5",
"created": {
"$date": {
"$numberLong": "1738333353245"
}
},
"crossReference": {
"enseGeneID": "ENSG00000290203",
"enseRnaID": [
"ENST00000703585.1"
],
"enseProtID": [
"ENSP00000515387.1"
]
},
"chrom": {
"pos": "15",
"type": 1
},
"desc": "SPESP1-NOX5 readthrough",
"geneType": 5,
"ontology": [
{
"id": "R-HSA-8953897",
"term": "Cellular responses to stimuli",
"cat": 10
},
{
"id": "R-HSA-2262752",
"term": "Cellular responses to stress",
"cat": 11
},
{
"id": "R-HSA-9711123",
"term": "Cellular response to chemical stress",
"cat": 12
},
{
"id": "R-HSA-3299685",
"term": "Detoxification of Reactive Oxygen Species",
"cat": 13
}
],
"protein": [
{
"symbol": "NOX5_HUMAN",
"name": "NADPH oxidase 5",
"accession": [
"Q96PH1",
"B2RBJ4",
"Q08AN2",
"Q08AN3",
"Q8TEQ1",
"Q8TER4",
"Q96PH2",
"Q96PJ8",
"Q96PJ9",
"Q9H6E0",
"Q9HAM8"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"Rhea": [
"RHEA:63180",
"RHEA:63180",
"RHEA:63180",
"RHEA:63180"
],
"ChEBI": [
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18421",
"CHEBI:57783",
"CHEBI:58349",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18421",
"CHEBI:57783",
"CHEBI:58349",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18421",
"CHEBI:57783",
"CHEBI:58349",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18421",
"CHEBI:57783",
"CHEBI:58349",
"CHEBI:57692",
"CHEBI:18420",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108",
"CHEBI:29108"
],
"EC": [
"1.6.3.-"
],
"EMBL": [
"AF325189",
"AF325190",
"AF353088",
"AF353089",
"AK074058",
"AK074071",
"AK026011",
"AK314689",
"DQ314884",
"AC027088",
"AC087639",
"CH471082",
"BC125097",
"BC125098",
"AF317889"
],
"CCDS": [
"CCDS32276.2",
"CCDS53954.1"
],
"RefSeq": [
"NP_001171708.1",
"NP_001171709.1",
"NP_078781.3"
],
"PDB": [
"6SZ5",
"8U7Y",
"8U85",
"8U86",
"8U87"
],
"PDBsum": [
"6SZ5",
"8U7Y",
"8U85",
"8U86",
"8U87"
],
"AlphaFoldDB": [
"Q96PH1"
],
"EMDB": [
"EMD-42013",
"EMD-42014",
"EMD-42015",
"EMD-42016",
"EMD-42345",
"EMD-42348"
],
"SMR": [
"Q96PH1"
],
"BioGRID": [
"122660"
],
"IntAct": [
"Q96PH1"
],
"MINT": [
"Q96PH1"
],
"STRING": [
"9606.ENSP00000373518"
],
"BindingDB": [
"Q96PH1"
],
"ChEMBL": [
"CHEMBL1926497"
],
"GuidetoPHARMACOLOGY": [
"3005"
],
"PeroxiBase": [
"6024"
],
"TCDB": [
"5.B.1.1.5"
],
"iPTMnet": [
"Q96PH1"
],
"PhosphoSitePlus": [
"Q96PH1"
],
"BioMuta": [
"NOX5"
],
"DMDM": [
"74717091"
],
"jPOST": [
"Q96PH1"
],
"MassIVE": [
"Q96PH1"
],
"PaxDb": [
"9606-ENSP00000373518"
],
"PeptideAtlas": [
"Q96PH1"
],
"ProteomicsDB": [
"77694",
"77695",
"77696",
"77697",
"77698",
"77699"
],
"Antibodypedia": [
"57978"
],
"DNASU": [
"79400"
],
"Ensembl": [
"ENST00000260364.9",
"ENST00000388866.8",
"ENST00000448182.7",
"ENST00000530406.7",
"ENST00000703585.1"
],
"KEGG": [
"hsa:79400"
],
"MANE-Select": [
"ENST00000388866.8"
],
"UCSC": [
"uc002arp.3"
],
"AGR": [
"HGNC:14874"
],
"CTD": [
"79400"
],
"DisGeNET": [
"79400"
],
"GeneCards": [
"NOX5"
],
"HGNC": [
"HGNC:14874"
],
"HPA": [
"ENSG00000255346",
"ENSG00000290203"
],
"MIM": [
"606572"
],
"neXtProt": [
"NX_Q96PH1"
],
"OpenTargets": [
"ENSG00000255346"
],
"PharmGKB": [
"PA31693"
],
"VEuPathDB": [
"HostDB:ENSG00000255346"
],
"eggNOG": [
"KOG0039"
],
"GeneTree": [
"ENSGT00940000162591"
],
"HOGENOM": [
"CLU_009773_0_0_1"
],
"InParanoid": [
"Q96PH1"
],
"OMA": [
"QWTTRLY"
],
"OrthoDB": [
"367877at2759"
],
"PhylomeDB": [
"Q96PH1"
],
"TreeFam": [
"TF324099"
],
"PathwayCommons": [
"Q96PH1"
],
"Reactome": [
"R-HSA-3299685"
],
"SABIO-RK": [
"Q96PH1"
],
"SignaLink": [
"Q96PH1"
],
"SIGNOR": [
"Q96PH1"
],
"BioGRID-ORCS": [
"79400"
],
"ChiTaRS": [
"NOX5"
],
"GeneWiki": [
"NOX5"
],
"GenomeRNAi": [
"79400"
],
"Pharos": [
"Q96PH1"
],
"PRO": [
"PR:Q96PH1"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q96PH1"
],
"Bgee": [
"ENSG00000255346"
],
"ExpressionAtlas": [
"Q96PH1"
],
"GO": [
"GO:0005783",
"GO:0005789",
"GO:0043020",
"GO:0005886",
"GO:0005509",
"GO:0050660",
"GO:0020037",
"GO:0050661",
"GO:0015252",
"GO:0016175",
"GO:0106292",
"GO:0001525",
"GO:0006915",
"GO:0061640",
"GO:0006952",
"GO:0001935",
"GO:0001819",
"GO:2000379",
"GO:1902600",
"GO:0043012",
"GO:0042554"
],
"CDD": [
"cd00051",
"cd06186"
],
"Gene3D": [
"1.10.238.10",
"3.40.50.80",
"2.40.30.10"
],
"InterPro": [
"IPR011992",
"IPR018247",
"IPR002048",
"IPR013112",
"IPR017927",
"IPR013130",
"IPR013121",
"IPR039261",
"IPR050369",
"IPR017938"
],
"PANTHER": [
"PTHR11972",
"PTHR11972:SF58"
],
"Pfam": [
"PF13202",
"PF13405",
"PF08022",
"PF01794",
"PF08030"
],
"SFLD": [
"SFLDS00052",
"SFLDG01168",
"SFLDG01169"
],
"SMART": [
"SM00054"
],
"SUPFAM": [
"SSF47473",
"SSF52343",
"SSF63380"
],
"PROSITE": [
"PS00018",
"PS50222",
"PS51384"
]
},
"citations": [
{
"title": "A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes.",
"pubmedID": "11483596",
"doi": "10.1074/jbc.m103034200"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "Analysis of the DNA sequence and duplication history of human chromosome 15.",
"pubmedID": "16572171",
"doi": "10.1038/nature04601"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation.",
"pubmedID": "15994299",
"doi": "10.1074/jbc.m501882200"
},
{
"title": "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.",
"pubmedID": "11376945",
"doi": "10.1016/s0378-1119(01)00449-8"
},
{
"title": "NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.",
"pubmedID": "12686516",
"doi": "10.1152/ajpcell.00525.2002"
},
{
"title": "Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5).",
"pubmedID": "14982937",
"doi": "10.1074/jbc.m310268200"
},
{
"title": "NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts.",
"pubmedID": "16179589",
"doi": "10.1161/01.res.0000187457.24338.3d"
},
{
"title": "Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia.",
"pubmedID": "16339585",
"doi": "10.4049/jimmunol.175.12.8424"
},
{
"title": "NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation.",
"pubmedID": "17587483",
"doi": "10.1016/j.biochi.2007.05.004"
},
{
"title": "NOX5 variants are functionally active in endothelial cells.",
"pubmedID": "17275676",
"doi": "10.1016/j.freeradbiomed.2006.10.054"
},
{
"title": "Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain.",
"pubmedID": "21319793",
"doi": "10.1021/bi1020088"
},
{
"title": "Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5.",
"pubmedID": "21642394",
"doi": "10.1124/mol.110.070193"
},
{
"title": "Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels.",
"pubmedID": "22427510",
"doi": "10.1152/ajpheart.00910.2011"
},
{
"title": "Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation.",
"pubmedID": "22387196",
"doi": "10.1016/j.freeradbiomed.2012.02.029"
},
{
"title": "Regulation of NADPH oxidase 5 by protein kinase C isoforms.",
"pubmedID": "24505490",
"doi": "10.1371/journal.pone.0088405"
},
{
"title": "Ca2+ -binding-region-dependent cell surface localization of NADPH oxidase Nox5.",
"pubmedID": "36653838",
"doi": "10.1002/1873-3468.14577"
},
{
"title": "On the mechanism of calcium-dependent activation of NADPH oxidase 5 (NOX5).",
"pubmedID": "31785178",
"doi": "10.1111/febs.15160"
}
],
"sequence": {
"length": 765,
"mass": 86439,
"checksum": "96B57225BF919682",
"modified": {
"$date": {
"$numberLong": "1007164800000"
}
},
"version": 1,
"sequence": "MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESFFAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLFQVYDIDVCARQGASAGTEWGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLPDEKLDQLTLALFESADADGNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGIGWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF"
},
"existence": 0,
"relevance": 1,
"proteinID": 1990320178
},
{
"symbol": "A3QRJ0_HUMAN",
"accession": [
"A3QRJ0"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"DQ413001",
"CH471082",
"ABD92513.1",
"EAW77832.1"
],
"RefSeq": [
"NP_001171708.1",
"NP_001171709.1",
"NP_078781.3"
],
"AlphaFoldDB": [
"A3QRJ0"
],
"PeptideAtlas": [
"A3QRJ0"
],
"DNASU": [
"79400"
],
"KEGG": [
"hsa:79400"
],
"CTD": [
"79400"
],
"DisGeNET": [
"79400"
],
"OrthoDB": [
"367877at2759"
],
"BioGRID-ORCS": [
"79400"
],
"ChiTaRS": [
"NOX5"
],
"GO": [
"GO:0043020",
"GO:0016175",
"GO:0006952",
"GO:0042554"
],
"CDD": [
"cd06186"
],
"Gene3D": [
"3.40.50.80",
"2.40.30.10"
],
"InterPro": [
"IPR013112",
"IPR017927",
"IPR013130",
"IPR013121",
"IPR039261",
"IPR050369",
"IPR017938"
],
"PANTHER": [
"PTHR11972",
"PTHR11972:SF58"
],
"Pfam": [
"PF08022",
"PF01794",
"PF08030"
],
"SFLD": [
"SFLDS00052",
"SFLDG01168",
"SFLDG01169"
],
"SUPFAM": [
"SSF52343",
"SSF63380"
],
"PROSITE": [
"PS51384",
"PS51384"
],
"ARBA": [
"ARBA00004141",
"ARBA00022692",
"ARBA00022989",
"ARBA00023002",
"ARBA00023136"
],
"SAM": [
"Phobius"
]
},
"citations": [
{
"title": "The sequence of the human genome.",
"pubmedID": "11181995",
"doi": "10.1126/science.1058040"
},
{
"title": "NOX5 variants are functionally active in endothelial cells.",
"pubmedID": "17275676",
"doi": "10.1016/j.freeradbiomed.2006.10.054"
}
],
"sequence": {
"length": 565,
"mass": 64686,
"checksum": "29B3D454E4119993",
"modified": {
"$date": {
"$numberLong": "1175558400000"
}
},
"version": 1,
"sequence": "MENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLFCLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATWLAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGIGWVHGSASPTGVALLLLLLFMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFWKWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLNIPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVTMRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASILQSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQAEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDWSKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF"
},
"existence": 1,
"relevance": 2,
"proteinID": 923723929
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}