Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 1470
{
"geneID": 1470,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL591074.10"
]
},
"genePos": {
"start": 23823769,
"end": 23826729
},
"orientation": false,
"symbol": "CST2",
"created": {
"$date": {
"$numberLong": "1738333348745"
}
},
"crossReference": {
"enseGeneID": "ENSG00000170369",
"enseRnaID": [
"ENST00000304725.3"
],
"enseProtID": [
"ENSP00000307540.2"
]
},
"chrom": {
"pos": "20",
"type": 1,
"loc": "20p11.21"
},
"desc": "cystatin SA",
"geneType": 5,
"mim": [
{
"id": 123856,
"relation": 0
}
],
"ontology": [
{
"id": "GO:0004869",
"term": "cysteine-type endopeptidase inhibitor activity",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
25416956,
32296183
],
"cat": 0
},
{
"id": "GO:0001580",
"term": "detection of chemical stimulus involved in sensory perception of bitter taste",
"pubMed": [
24248522
],
"cat": 1
},
{
"id": "GO:0010466",
"term": "negative regulation of peptidase activity",
"cat": 1
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
22664934,
23580065
],
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
24248522
],
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"cat": 2
},
{
"id": "GO:0031982",
"term": "vesicle",
"cat": 2
}
],
"protein": [
{
"symbol": "CYTT_HUMAN",
"name": "Cystatin-SA",
"accession": [
"P09228",
"Q9UCQ7"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"M19673",
"M19671",
"M19672",
"AF319564",
"AL591074",
"BC062679"
],
"CCDS": [
"CCDS13161.1"
],
"PIR": [
"B29632"
],
"RefSeq": [
"NP_001313.1"
],
"AlphaFoldDB": [
"P09228"
],
"SMR": [
"P09228"
],
"BioGRID": [
"107852"
],
"IntAct": [
"P09228"
],
"STRING": [
"9606.ENSP00000307540"
],
"MEROPS": [
"I25.004",
"I25.009"
],
"BioMuta": [
"CST2"
],
"DMDM": [
"118192"
],
"jPOST": [
"P09228"
],
"MassIVE": [
"P09228"
],
"PaxDb": [
"9606-ENSP00000307540"
],
"PeptideAtlas": [
"P09228"
],
"PRIDE": [
"P09228"
],
"ProteomicsDB": [
"52208"
],
"Antibodypedia": [
"58258"
],
"DNASU": [
"1470"
],
"Ensembl": [
"ENST00000304725.3"
],
"KEGG": [
"hsa:1470"
],
"MANE-Select": [
"ENST00000304725.3"
],
"UCSC": [
"uc002wtq.2"
],
"AGR": [
"HGNC:2474"
],
"CTD": [
"1470"
],
"DisGeNET": [
"1470"
],
"GeneCards": [
"CST2"
],
"HGNC": [
"HGNC:2474"
],
"HPA": [
"ENSG00000170369"
],
"MIM": [
"123856"
],
"neXtProt": [
"NX_P09228"
],
"OpenTargets": [
"ENSG00000170369"
],
"PharmGKB": [
"PA26975"
],
"VEuPathDB": [
"HostDB:ENSG00000170369"
],
"eggNOG": [
"ENOG502SC50"
],
"GeneTree": [
"ENSGT00940000163410"
],
"HOGENOM": [
"CLU_118168_0_1_1"
],
"InParanoid": [
"P09228"
],
"OMA": [
"LAFGFCQ"
],
"OrthoDB": [
"3086783at2759"
],
"PhylomeDB": [
"P09228"
],
"PathwayCommons": [
"P09228"
],
"SignaLink": [
"P09228"
],
"BioGRID-ORCS": [
"1470"
],
"GeneWiki": [
"CST2"
],
"GenomeRNAi": [
"1470"
],
"Pharos": [
"P09228"
],
"PRO": [
"PR:P09228"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P09228"
],
"Bgee": [
"ENSG00000170369"
],
"GO": [
"GO:0005737",
"GO:0005615",
"GO:0031982",
"GO:0004869",
"GO:0001580"
],
"CDD": [
"cd00042"
],
"Gene3D": [
"3.10.450.10"
],
"InterPro": [
"IPR000010",
"IPR046350",
"IPR018073"
],
"PANTHER": [
"PTHR46186",
"PTHR46186:SF3"
],
"Pfam": [
"PF00031"
],
"SMART": [
"SM00043"
],
"SUPFAM": [
"SSF54403"
],
"PROSITE": [
"PS00287"
]
},
"citations": [
{
"title": "Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family.",
"pubmedID": "3446578",
"doi": "10.1016/0378-1119(87)90196-x"
},
{
"title": "The DNA sequence and comparative analysis of human chromosome 20.",
"pubmedID": "11780052",
"doi": "10.1038/414865a"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S.",
"pubmedID": "1778989",
"doi": "10.1093/oxfordjournals.jbchem.a123634"
},
{
"title": "Signal peptide prediction based on analysis of experimentally verified cleavage sites.",
"pubmedID": "15340161",
"doi": "10.1110/ps.04682504"
},
{
"title": "Characterization and amino acid sequence of a new acidic cysteine proteinase inhibitor (cystatin SA) structurally closely related to cystatin S, from human whole saliva.",
"pubmedID": "3436950",
"doi": "10.1093/oxfordjournals.jbchem.a122107"
},
{
"title": "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes.",
"pubmedID": "3202964"
},
{
"title": "Expression of type 2 cystatin genes CST1-CST5 in adult human tissues and the developing submandibular gland.",
"pubmedID": "11879580",
"doi": "10.1089/10445490252810311"
},
{
"title": "Confident assignment of intact mass tags to human salivary cystatins using top-down Fourier-transform ion cyclotron resonance mass spectrometry.",
"pubmedID": "20189825",
"doi": "10.1016/j.jasms.2010.01.025"
},
{
"title": "Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.",
"pubmedID": "25946035",
"doi": "10.1021/acs.jproteome.5b00179"
}
],
"sequence": {
"length": 141,
"mass": 16445,
"checksum": "EB54915B1B977AA2",
"modified": {
"$date": {
"$numberLong": "615254400000"
}
},
"version": 1,
"sequence": "MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATEDEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSFQIYEVPWEDRMSLVNSRCQEA"
},
"existence": 0,
"relevance": 1,
"proteinID": 3961827958
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}