Details Currently Unavailable
A detailed, interactive page could not be generated for the requested gene. This usually happens when there is no significant expression data (CSI) available for it in our database.
AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 1544
{
"geneID": 1544,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC091230.23"
]
},
"genePos": {
"start": 31304,
"end": 39066
},
"orientation": false,
"symbol": "CYP1A2",
"created": {
"$date": {
"$numberLong": "1738333348759"
}
},
"crossReference": {
"enseGeneID": "ENSG00000140505",
"enseRnaID": [
"ENST00000343932.5"
],
"enseProtID": [
"ENSP00000342007.4"
]
},
"chrom": {
"pos": "15",
"type": 1,
"loc": "15q24.1"
},
"desc": "cytochrome P450 family 1 subfamily A member 2",
"geneType": 5,
"mim": [
{
"id": 124060,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-1430728",
"term": "Metabolism",
"cat": 10
},
{
"id": "R-HSA-211859",
"term": "Biological oxidations",
"cat": 11
},
{
"id": "R-HSA-556833",
"term": "Metabolism of lipids",
"cat": 11
},
{
"id": "R-HSA-156580",
"term": "Phase II - Conjugation of compounds",
"cat": 12
},
{
"id": "R-HSA-211945",
"term": "Phase I - Functionalization of compounds",
"cat": 12
},
{
"id": "R-HSA-5423646",
"term": "Aflatoxin activation and detoxification",
"cat": 12
},
{
"id": "R-HSA-8978868",
"term": "Fatty acid metabolism",
"cat": 12
},
{
"id": "R-HSA-9018678",
"term": "Biosynthesis of specialized proresolving mediators (SPMs)",
"cat": 12
},
{
"id": "R-HSA-156581",
"term": "Methylation",
"cat": 13
},
{
"id": "R-HSA-211897",
"term": "Cytochrome P450 - arranged by substrate type",
"cat": 13
},
{
"id": "R-HSA-2142753",
"term": "Arachidonate metabolism",
"cat": 13
},
{
"id": "R-HSA-9018677",
"term": "Biosynthesis of DHA-derived SPMs",
"cat": 13
},
{
"id": "R-HSA-211981",
"term": "Xenobiotics",
"cat": 14
},
{
"id": "R-HSA-2142670",
"term": "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)",
"cat": 14
},
{
"id": "R-HSA-2142816",
"term": "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)",
"cat": 14
},
{
"id": "R-HSA-9018681",
"term": "Biosynthesis of protectins",
"cat": 14
},
{
"id": "R-HSA-9018682",
"term": "Biosynthesis of maresins",
"cat": 14
},
{
"id": "R-HSA-211957",
"term": "Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2",
"cat": 15
},
{
"id": "R-HSA-9027307",
"term": "Biosynthesis of maresin-like SPMs",
"cat": 15
},
{
"id": "GO:0004497",
"term": "monooxygenase activity",
"cat": 0
},
{
"id": "GO:0004497",
"term": "monooxygenase activity",
"pubMed": [
15327587,
19651758
],
"cat": 0
},
{
"id": "GO:0005506",
"term": "iron ion binding",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
26988023,
32296183
],
"cat": 0
},
{
"id": "GO:0009055",
"term": "electron transfer activity",
"pubMed": [
2813353
],
"cat": 0
},
{
"id": "GO:0016491",
"term": "oxidoreductase activity",
"pubMed": [
16401082,
19219744
],
"cat": 0
},
{
"id": "GO:0016712",
"term": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen",
"pubMed": [
2813353
],
"cat": 0
},
{
"id": "GO:0019899",
"term": "enzyme binding",
"pubMed": [
15680923
],
"cat": 0
},
{
"id": "GO:0020037",
"term": "heme binding",
"pubMed": [
17311915
],
"cat": 0
},
{
"id": "GO:0032451",
"term": "demethylase activity",
"pubMed": [
2813353
],
"cat": 0
},
{
"id": "GO:0034875",
"term": "caffeine oxidase activity",
"pubMed": [
18619574
],
"cat": 0
},
{
"id": "GO:0070330",
"term": "aromatase activity",
"cat": 0
},
{
"id": "GO:0101020",
"term": "estrogen 16-alpha-hydroxylase activity",
"pubMed": [
11555828
],
"cat": 0
},
{
"id": "GO:0101021",
"term": "estrogen 2-hydroxylase activity",
"pubMed": [
11555828,
12865317
],
"cat": 0
},
{
"id": "GO:0106256",
"term": "hydroperoxy icosatetraenoate dehydratase activity",
"cat": 0
},
{
"id": "GO:0006706",
"term": "steroid catabolic process",
"pubMed": [
18356043
],
"cat": 1
},
{
"id": "GO:0006778",
"term": "porphyrin-containing compound metabolic process",
"cat": 1
},
{
"id": "GO:0006805",
"term": "xenobiotic metabolic process",
"pubMed": [
15327587,
19219744
],
"cat": 1
},
{
"id": "GO:0006805",
"term": "xenobiotic metabolic process",
"cat": 1
},
{
"id": "GO:0008203",
"term": "cholesterol metabolic process",
"cat": 1
},
{
"id": "GO:0008210",
"term": "estrogen metabolic process",
"pubMed": [
11555828,
12865317
],
"cat": 1
},
{
"id": "GO:0009403",
"term": "toxin biosynthetic process",
"pubMed": [
11511187
],
"cat": 1
},
{
"id": "GO:0009791",
"term": "post-embryonic development",
"cat": 1
},
{
"id": "GO:0009820",
"term": "alkaloid metabolic process",
"pubMed": [
11511187
],
"cat": 1
},
{
"id": "GO:0010468",
"term": "regulation of gene expression",
"cat": 1
},
{
"id": "GO:0016098",
"term": "monoterpenoid metabolic process",
"pubMed": [
16401082
],
"cat": 1
},
{
"id": "GO:0018894",
"term": "dibenzo-p-dioxin metabolic process",
"cat": 1
},
{
"id": "GO:0019373",
"term": "epoxygenase P450 pathway",
"cat": 1
},
{
"id": "GO:0030324",
"term": "lung development",
"cat": 1
},
{
"id": "GO:0032259",
"term": "methylation",
"cat": 1
},
{
"id": "GO:0032787",
"term": "monocarboxylic acid metabolic process",
"pubMed": [
19651758
],
"cat": 1
},
{
"id": "GO:0042178",
"term": "xenobiotic catabolic process",
"pubMed": [
18619574
],
"cat": 1
},
{
"id": "GO:0042178",
"term": "xenobiotic catabolic process",
"pubMed": [
18356043
],
"cat": 1
},
{
"id": "GO:0042572",
"term": "retinol metabolic process",
"pubMed": [
10681376
],
"cat": 1
},
{
"id": "GO:0042572",
"term": "retinol metabolic process",
"cat": 1
},
{
"id": "GO:0042759",
"term": "long-chain fatty acid biosynthetic process",
"cat": 1
},
{
"id": "GO:0045333",
"term": "cellular respiration",
"cat": 1
},
{
"id": "GO:0046222",
"term": "aflatoxin metabolic process",
"cat": 1
},
{
"id": "GO:0050665",
"term": "hydrogen peroxide biosynthetic process",
"cat": 1
},
{
"id": "GO:0070989",
"term": "oxidative demethylation",
"pubMed": [
18619574
],
"cat": 1
},
{
"id": "GO:0071276",
"term": "cellular response to cadmium ion",
"cat": 1
},
{
"id": "GO:0097267",
"term": "omega-hydroxylase P450 pathway",
"cat": 1
},
{
"id": "GO:0005789",
"term": "endoplasmic reticulum membrane",
"cat": 2
},
{
"id": "GO:0043231",
"term": "intracellular membrane-bounded organelle",
"cat": 2
},
{
"id": "GO:0043231",
"term": "intracellular membrane-bounded organelle",
"pubMed": [
2813353
],
"cat": 2
}
],
"protein": [
{
"symbol": "CP1A2_HUMAN",
"name": "CYPIA2",
"accession": [
"P05177",
"Q16754",
"Q6NWU3",
"Q6NWU5",
"Q9BXX7",
"Q9UK49"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"Rhea": [
"RHEA:17149",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:17150",
"RHEA:47212",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:47213",
"RHEA:47280",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:47281",
"RHEA:47208",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:47209",
"RHEA:47292",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:47293",
"RHEA:50256",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:50257",
"RHEA:42092",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:42093",
"RHEA:42088",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:42089",
"RHEA:49860",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:49861",
"RHEA:49856",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:49857",
"RHEA:39779",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:39780",
"RHEA:52120",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:52121",
"RHEA:48632",
"RHEA:48633",
"RHEA:37947",
"RHEA:37948",
"RHEA:48636",
"RHEA:48637",
"RHEA:48716",
"RHEA:48717",
"RHEA:52292",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:52293",
"RHEA:39759",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:39760",
"RHEA:52284",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:52285"
],
"ChEBI": [
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30879",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:142491",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:16469",
"CHEBI:28744",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:16469",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:62845",
"CHEBI:1156",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:17263",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:17263",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:87602",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:16113",
"CHEBI:42977",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:17336",
"CHEBI:17898",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:17898",
"CHEBI:35291",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:32395",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:131965",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:32395",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:131964",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:58562",
"CHEBI:76634",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:77016",
"CHEBI:136410",
"CHEBI:15377",
"CHEBI:57450",
"CHEBI:65342",
"CHEBI:15377",
"CHEBI:57444",
"CHEBI:75231",
"CHEBI:15377",
"CHEBI:57410",
"CHEBI:57446",
"CHEBI:15377",
"CHEBI:57466",
"CHEBI:90781",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:32395",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:136524",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:32395",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:76627",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30245",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:136522",
"CHEBI:30413",
"CHEBI:30413",
"CHEBI:18248"
],
"EC": [
"1.14.14.1",
"4.2.1.152"
],
"EMBL": [
"Z00036",
"M55053",
"M12078",
"L00389",
"L00384",
"L00385",
"L00386",
"L00388",
"L00387",
"M31667",
"M31664",
"M31665",
"M31666",
"AF182274",
"AF253322",
"DQ022432",
"BC067424",
"BC067425",
"BC067426",
"BC067427",
"BC067428",
"BC067429"
],
"CCDS": [
"CCDS32293.1"
],
"PIR": [
"S16718"
],
"RefSeq": [
"NP_000752.2"
],
"PDB": [
"2HI4"
],
"PDBsum": [
"2HI4"
],
"AlphaFoldDB": [
"P05177"
],
"SMR": [
"P05177"
],
"BioGRID": [
"107924"
],
"IntAct": [
"P05177"
],
"STRING": [
"9606.ENSP00000342007"
],
"BindingDB": [
"P05177"
],
"ChEMBL": [
"CHEMBL3356"
],
"DrugBank": [
"DB08496",
"DB01667",
"DB14132",
"DB04356",
"DB02489",
"DB11932",
"DB12001",
"DB05812",
"DB13573",
"DB01418",
"DB00316",
"DB15568",
"DB06594",
"DB00518",
"DB05396",
"DB00969",
"DB07453",
"DB01424",
"DB01223",
"DB01118",
"DB00321",
"DB00261",
"DB01217",
"DB01435",
"DB06605",
"DB05676",
"DB06413",
"DB06216",
"DB01072",
"DB15011",
"DB06442",
"DB06626",
"DB00993",
"DB00972",
"DB13203",
"DB05015",
"DB16703",
"DB06769",
"DB01086",
"DB06770",
"DB06771",
"DB06732",
"DB00195",
"DB04889",
"DB11967",
"DB13975",
"DB00188",
"DB12151",
"DB01558",
"DB14018",
"DB13812",
"DB00201",
"DB09061",
"DB14737",
"DB11791",
"DB06774",
"DB00564",
"DB06016",
"DB01136",
"DB12814",
"DB00477",
"DB00356",
"DB01166",
"DB00501",
"DB01012",
"DB00568",
"DB00827",
"DB00537",
"DB00215",
"DB12499",
"DB14025",
"DB00349",
"DB01242",
"DB00575",
"DB00758",
"DB00363",
"DB00286",
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"DB14635",
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"DB08912",
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"DB01254",
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"DB11511",
"DB12945",
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"DB01184",
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"DB09273",
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"DB00476",
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"DB15444",
"DB06210",
"DB13874",
"DB11718",
"DB00467",
"DB11404",
"DB00530",
"DB00783",
"DB13952",
"DB13953",
"DB13954",
"DB13955",
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"DB00655",
"DB04574",
"DB13592",
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"DB00499",
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"DB09078",
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"DB13634",
"DB00806",
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"DB08883",
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"DB00863",
"DB01367",
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"DB01045",
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"DB00740",
"DB14924",
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"DB00857",
"DB08880",
"DB11712",
"DB01412",
"DB00277",
"DB00730",
"DB01623",
"DB00208",
"DB06137",
"DB00697",
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{
"title": "Human P3(450): cDNA and complete amino acid sequence.",
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"doi": "10.1093/nar/14.16.6773"
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{
"title": "Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.",
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"doi": "10.1073/pnas.83.18.6731"
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{
"title": "Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.",
"pubmedID": "2575218",
"doi": "10.1210/mend-3-9-1399"
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{
"title": "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15.",
"pubmedID": "3681487"
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{
"title": "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation.",
"pubmedID": "11207026",
"doi": "10.1097/00008571-200102000-00001"
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{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
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"doi": "10.1101/gr.2596504"
},
{
"title": "Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.",
"pubmedID": "3517618"
},
{
"title": "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6.",
"pubmedID": "3000715",
"doi": "10.1089/dna.1985.4.395"
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{
"title": "Cytochromes P450 with bisallylic hydroxylation activity on arachidonic and linoleic acids studied with human recombinant enzymes and with human and rat liver microsomes.",
"pubmedID": "9435160"
},
{
"title": "Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.",
"pubmedID": "10681376"
},
{
"title": "Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol.",
"pubmedID": "11555828",
"doi": "10.1053/meta.2001.25592"
},
{
"title": "Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.",
"pubmedID": "12865317",
"doi": "10.1210/en.2003-0192"
},
{
"title": "Functional characterization of four allelic variants of human cytochrome P450 1A2.",
"pubmedID": "14725854",
"doi": "10.1016/j.abb.2003.11.019"
},
{
"title": "Stereoselective epoxidation of the last double bond of polyunsaturated fatty acids by human cytochromes P450.",
"pubmedID": "19965576",
"doi": "10.1194/jlr.m003061"
},
{
"title": "Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids.",
"pubmedID": "21068195",
"doi": "10.1124/dmd.110.035121"
},
{
"title": "Cholesterol 25-hydroxylation activity of CYP3A.",
"pubmedID": "21576599",
"doi": "10.1194/jlr.m014084"
},
{
"title": "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.",
"pubmedID": "24275569",
"doi": "10.1016/j.jprot.2013.11.014"
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{
"title": "Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.",
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"doi": "10.1038/ncomms11030"
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{
"title": "Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.",
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"doi": "10.1074/jbc.m611692200"
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{
"title": "Detection of a novel cytochrome P-450 1A2 polymorphism (F21L) in Chinese.",
"pubmedID": "9884316"
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{
"title": "Five novel natural allelic variants-951A->C, 1042G->A (D348N), 1156A->T (I386F), 1217G->A (C406Y) and 1291C->T (C431Y)-of the human CYP1A2 gene in a French Caucasian population.",
"pubmedID": "11295848"
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{
"title": "Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes.",
"pubmedID": "14563787",
"doi": "10.1124/jpet.103.055798"
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{
"title": "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.",
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{
"title": "Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.",
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"title": "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.",
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"title": "Coffee, CYP1A2 genotype, and risk of myocardial infarction.",
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"doi": "10.1001/jama.295.10.1135"
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