Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 1618
{
"geneID": 1618,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC010139.4"
]
},
"genePos": {
"start": 5077,
"end": 23708
},
"orientation": false,
"symbol": "DAZL",
"created": {
"$date": {
"$numberLong": "1738333348762"
}
},
"crossReference": {
"enseGeneID": "ENSG00000092345",
"enseRnaID": [
"ENST00000250863.12"
],
"enseProtID": [
"ENSP00000250863.8"
]
},
"chrom": {
"pos": "3",
"type": 1,
"loc": "3p24.3"
},
"desc": "deleted in azoospermia like",
"geneType": 5,
"mim": [
{
"id": 601486,
"relation": 0
}
],
"ontology": [
{
"id": "GO:0003723",
"term": "RNA binding",
"pubMed": [
8968755
],
"cat": 0
},
{
"id": "GO:0003730",
"term": "mRNA 3'-UTR binding",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
10857750,
12511597,
16001084
],
"cat": 0
},
{
"id": "GO:0008494",
"term": "translation activator activity",
"cat": 0
},
{
"id": "GO:0008494",
"term": "translation activator activity",
"pubMed": [
16001084
],
"cat": 0
},
{
"id": "GO:0042802",
"term": "identical protein binding",
"cat": 0
},
{
"id": "GO:0001556",
"term": "oocyte maturation",
"cat": 1
},
{
"id": "GO:0007147",
"term": "female meiosis II",
"cat": 1
},
{
"id": "GO:0007281",
"term": "germ cell development",
"pubMed": [
9288969
],
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0045836",
"term": "positive regulation of meiotic nuclear division",
"cat": 1
},
{
"id": "GO:0045948",
"term": "positive regulation of translational initiation",
"cat": 1
},
{
"id": "GO:0045948",
"term": "positive regulation of translational initiation",
"pubMed": [
16001084
],
"cat": 1
},
{
"id": "GO:0070935",
"term": "3'-UTR-mediated mRNA stabilization",
"cat": 1
},
{
"id": "GO:0005634",
"term": "nucleus",
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"cat": 2
},
{
"id": "GO:0005840",
"term": "ribosome",
"cat": 2
},
{
"id": "GO:0032991",
"term": "protein-containing complex",
"pubMed": [
10857750
],
"cat": 2
}
],
"protein": [
{
"symbol": "DAZL_HUMAN",
"name": "Deleted in azoospermia-like",
"accession": [
"Q92904",
"O15396",
"Q5HYB4",
"Q92909"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"U65918",
"U66726",
"U66078",
"U77476",
"U77467",
"U77468",
"U77469",
"U77470",
"U77471",
"U77472",
"U77473",
"U77474",
"U77475",
"AK303026",
"BX648638",
"AC010139",
"CH471055",
"BC027595"
],
"CCDS": [
"CCDS43059.1",
"CCDS54556.1"
],
"RefSeq": [
"NP_001177740.1",
"NP_001342.2"
],
"AlphaFoldDB": [
"Q92904"
],
"SMR": [
"Q92904"
],
"BioGRID": [
"107987"
],
"IntAct": [
"Q92904"
],
"STRING": [
"9606.ENSP00000250863"
],
"iPTMnet": [
"Q92904"
],
"PhosphoSitePlus": [
"Q92904"
],
"BioMuta": [
"DAZL"
],
"DMDM": [
"27805453"
],
"MassIVE": [
"Q92904"
],
"PaxDb": [
"9606-ENSP00000250863"
],
"PeptideAtlas": [
"Q92904"
],
"ProteomicsDB": [
"75589",
"75590"
],
"Antibodypedia": [
"6122"
],
"DNASU": [
"1618"
],
"Ensembl": [
"ENST00000250863.12",
"ENST00000399444.7"
],
"KEGG": [
"hsa:1618"
],
"MANE-Select": [
"ENST00000399444.7"
],
"UCSC": [
"uc003cba.4"
],
"AGR": [
"HGNC:2685"
],
"CTD": [
"1618"
],
"DisGeNET": [
"1618"
],
"GeneCards": [
"DAZL"
],
"HGNC": [
"HGNC:2685"
],
"HPA": [
"ENSG00000092345"
],
"MIM": [
"601486"
],
"neXtProt": [
"NX_Q92904"
],
"OpenTargets": [
"ENSG00000092345"
],
"PharmGKB": [
"PA27155"
],
"VEuPathDB": [
"HostDB:ENSG00000092345"
],
"eggNOG": [
"KOG0118"
],
"GeneTree": [
"ENSGT00530000063480"
],
"HOGENOM": [
"CLU_084802_0_0_1"
],
"InParanoid": [
"Q92904"
],
"OMA": [
"SQEDYFK"
],
"OrthoDB": [
"3964771at2759"
],
"PhylomeDB": [
"Q92904"
],
"TreeFam": [
"TF324396"
],
"PathwayCommons": [
"Q92904"
],
"SignaLink": [
"Q92904"
],
"BioGRID-ORCS": [
"1618"
],
"ChiTaRS": [
"DAZL"
],
"GeneWiki": [
"DAZL"
],
"GenomeRNAi": [
"1618"
],
"Pharos": [
"Q92904"
],
"PRO": [
"PR:Q92904"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q92904"
],
"Bgee": [
"ENSG00000092345"
],
"ExpressionAtlas": [
"Q92904"
],
"GO": [
"GO:0005737",
"GO:0005634",
"GO:0032991",
"GO:0005840",
"GO:0042802",
"GO:0003730",
"GO:0003723",
"GO:0008494",
"GO:0070935",
"GO:0007147",
"GO:0007281",
"GO:0001556",
"GO:0045836",
"GO:0045948",
"GO:0007283"
],
"CDD": [
"cd12672"
],
"Gene3D": [
"3.30.70.330"
],
"InterPro": [
"IPR043628",
"IPR037551",
"IPR012677",
"IPR035979",
"IPR000504"
],
"PANTHER": [
"PTHR11176",
"PTHR11176:SF4"
],
"Pfam": [
"PF18872",
"PF00076"
],
"SMART": [
"SM00360"
],
"SUPFAM": [
"SSF54928"
],
"PROSITE": [
"PS51890",
"PS50102"
]
},
"citations": [
{
"title": "The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned.",
"pubmedID": "8896558",
"doi": "10.1038/ng1196-292"
},
{
"title": "A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad.",
"pubmedID": "8968755",
"doi": "10.1093/hmg/5.12.2005"
},
{
"title": "The human autosomal gene DAZLA: testis specificity and a candidate for male infertility.",
"pubmedID": "8968756",
"doi": "10.1093/hmg/5.12.2013"
},
{
"title": "A putative human male infertility gene DAZLA: genomic structure and methylation status.",
"pubmedID": "9294855",
"doi": "10.1093/molehr/3.8.705"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "The full-ORF clone resource of the German cDNA consortium.",
"pubmedID": "17974005",
"doi": "10.1186/1471-2164-8-399"
},
{
"title": "The DNA sequence, annotation and analysis of human chromosome 3.",
"pubmedID": "16641997",
"doi": "10.1038/nature04728"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.",
"pubmedID": "10857750",
"doi": "10.1006/geno.2000.6169"
},
{
"title": "A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans.",
"pubmedID": "11390979",
"doi": "10.1073/pnas.131090498"
},
{
"title": "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins.",
"pubmedID": "12511597",
"doi": "10.1073/pnas.0234478100"
},
{
"title": "Association of a single-nucleotide polymorphism of the deleted-in-azoospermia-like gene with susceptibility to spermatogenic failure.",
"pubmedID": "12414900",
"doi": "10.1210/jc.2002-020016"
},
{
"title": "Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL.",
"pubmedID": "22021443",
"doi": "10.1073/pnas.1105211108"
}
],
"sequence": {
"length": 295,
"mass": 33178,
"checksum": "21B360739B35B95F",
"modified": {
"$date": {
"$numberLong": "854755200000"
}
},
"version": 1,
"sequence": "MSTANPETPNSTISREASTQSSSAATSQGYILPEGKIMPNTVFVGGIDVRMDETEIRSFFARYGSVKEVKIITDRTGVSKGYGFVSFFNDVDVQKIVESQINFHGKKLKLGPAIRKQNLCAYHVQPRPLVFNHPPPPQFQNVWTNPNTETYMQPTTTMNPITQYVQAYPTYPNSPVQVITGYQLPVYNYQMPPQWPVGEQRSYVVPPAYSAVNYHCNEVDPGAEVVPNECSVHEATPPSGNGPQKKSVDRSIQTVVSCLFNPENRLRNSVVTQDDYFKDKRVHHFRRSRAMLKSV"
},
"existence": 0,
"relevance": 1,
"proteinID": 4231019296
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}