Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 1761
{
"geneID": 1761,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL136365.9"
]
},
"genePos": {
"start": 841697,
"end": 969090
},
"orientation": true,
"symbol": "DMRT1",
"created": {
"$date": {
"$numberLong": "1738333348765"
}
},
"crossReference": {
"enseGeneID": "ENSG00000137090",
"enseRnaID": [
"ENST00000382276.8"
],
"enseProtID": [
"ENSP00000371711.3"
]
},
"chrom": {
"pos": "9",
"type": 1,
"loc": "9p24.3"
},
"desc": "doublesex and mab-3 related transcription factor 1",
"geneType": 5,
"mim": [
{
"id": 602424,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-1266738",
"term": "Developmental Biology",
"cat": 10
},
{
"id": "R-HSA-9690406",
"term": "Transcriptional regulation of testis differentiation",
"cat": 11
},
{
"id": "GO:0000978",
"term": "RNA polymerase II cis-regulatory region sequence-specific DNA binding",
"cat": 0
},
{
"id": "GO:0000981",
"term": "DNA-binding transcription factor activity, RNA polymerase II-specific",
"cat": 0
},
{
"id": "GO:0000987",
"term": "cis-regulatory region sequence-specific DNA binding",
"cat": 0
},
{
"id": "GO:0001228",
"term": "DNA-binding transcription activator activity, RNA polymerase II-specific",
"cat": 0
},
{
"id": "GO:0003682",
"term": "chromatin binding",
"cat": 0
},
{
"id": "GO:0042802",
"term": "identical protein binding",
"pubMed": [
26005864
],
"cat": 0
},
{
"id": "GO:0046872",
"term": "metal ion binding",
"cat": 0
},
{
"id": "GO:1990837",
"term": "sequence-specific double-stranded DNA binding",
"pubMed": [
28473536
],
"cat": 0
},
{
"id": "GO:0000122",
"term": "negative regulation of transcription by RNA polymerase II",
"cat": 1
},
{
"id": "GO:0000902",
"term": "cell morphogenesis",
"cat": 1
},
{
"id": "GO:0002176",
"term": "male germ cell proliferation",
"cat": 1
},
{
"id": "GO:0006357",
"term": "regulation of transcription by RNA polymerase II",
"cat": 1
},
{
"id": "GO:0007127",
"term": "meiosis I",
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0007548",
"term": "sex differentiation",
"cat": 1
},
{
"id": "GO:0008354",
"term": "germ cell migration",
"cat": 1
},
{
"id": "GO:0030238",
"term": "male sex determination",
"cat": 1
},
{
"id": "GO:0035556",
"term": "intracellular signal transduction",
"cat": 1
},
{
"id": "GO:0045835",
"term": "negative regulation of meiotic nuclear division",
"cat": 1
},
{
"id": "GO:0045840",
"term": "positive regulation of mitotic nuclear division",
"cat": 1
},
{
"id": "GO:0045944",
"term": "positive regulation of transcription by RNA polymerase II",
"cat": 1
},
{
"id": "GO:0046661",
"term": "male sex differentiation",
"cat": 1
},
{
"id": "GO:0048599",
"term": "oocyte development",
"cat": 1
},
{
"id": "GO:0060008",
"term": "Sertoli cell differentiation",
"cat": 1
},
{
"id": "GO:0060009",
"term": "Sertoli cell development",
"cat": 1
},
{
"id": "GO:0060903",
"term": "positive regulation of meiosis I",
"cat": 1
},
{
"id": "GO:1900107",
"term": "regulation of nodal signaling pathway",
"cat": 1
},
{
"id": "GO:2000020",
"term": "positive regulation of male gonad development",
"cat": 1
},
{
"id": "GO:0000785",
"term": "chromatin",
"cat": 2
},
{
"id": "GO:0001674",
"term": "female germ cell nucleus",
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
22899867
],
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"cat": 2
}
],
"protein": [
{
"symbol": "DMRT1_HUMAN",
"name": "Doublesex- and mab-3-related transcription factor 1",
"accession": [
"Q9Y5R6",
"B2R913",
"Q6T1H8",
"Q6T1H9",
"Q8IW77"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"273300",
"154230",
"154230",
"273300",
"602424"
],
"EMBL": [
"AF130728",
"AL162131",
"AY442914",
"AY442915",
"AK313594",
"AJ276801",
"AL136365",
"CH471071",
"BC040847"
],
"CCDS": [
"CCDS6442.1"
],
"RefSeq": [
"NP_068770.2"
],
"PDB": [
"4YJ0"
],
"PDBsum": [
"4YJ0"
],
"AlphaFoldDB": [
"Q9Y5R6"
],
"SMR": [
"Q9Y5R6"
],
"BioGRID": [
"108101"
],
"DIP": [
"DIP-58084N"
],
"IntAct": [
"Q9Y5R6"
],
"MINT": [
"Q9Y5R6"
],
"STRING": [
"9606.ENSP00000371711"
],
"iPTMnet": [
"Q9Y5R6"
],
"PhosphoSitePlus": [
"Q9Y5R6"
],
"BioMuta": [
"DMRT1"
],
"DMDM": [
"83305820"
],
"MassIVE": [
"Q9Y5R6"
],
"PaxDb": [
"9606-ENSP00000371711"
],
"PeptideAtlas": [
"Q9Y5R6"
],
"ProteomicsDB": [
"86485",
"86486",
"86487"
],
"Antibodypedia": [
"23777"
],
"DNASU": [
"1761"
],
"Ensembl": [
"ENST00000382276.8"
],
"KEGG": [
"hsa:1761"
],
"MANE-Select": [
"ENST00000382276.8"
],
"UCSC": [
"uc003zgv.5"
],
"AGR": [
"HGNC:2934"
],
"CTD": [
"1761"
],
"DisGeNET": [
"1761"
],
"GeneCards": [
"DMRT1"
],
"GeneReviews": [
"DMRT1"
],
"HGNC": [
"HGNC:2934"
],
"HPA": [
"ENSG00000137090"
],
"MalaCards": [
"DMRT1"
],
"neXtProt": [
"NX_Q9Y5R6"
],
"OpenTargets": [
"ENSG00000137090"
],
"Orphanet": [
"242"
],
"PharmGKB": [
"PA27381"
],
"VEuPathDB": [
"HostDB:ENSG00000137090"
],
"eggNOG": [
"KOG3815"
],
"GeneTree": [
"ENSGT00940000156489"
],
"HOGENOM": [
"CLU_069148_0_0_1"
],
"InParanoid": [
"Q9Y5R6"
],
"OMA": [
"CLMTECS"
],
"OrthoDB": [
"5358564at2759"
],
"PhylomeDB": [
"Q9Y5R6"
],
"TreeFam": [
"TF317837"
],
"PathwayCommons": [
"Q9Y5R6"
],
"Reactome": [
"R-HSA-9690406"
],
"SignaLink": [
"Q9Y5R6"
],
"BioGRID-ORCS": [
"1761"
],
"EvolutionaryTrace": [
"Q9Y5R6"
],
"GeneWiki": [
"DMRT1"
],
"GenomeRNAi": [
"1761"
],
"Pharos": [
"Q9Y5R6"
],
"PRO": [
"PR:Q9Y5R6"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q9Y5R6"
],
"Bgee": [
"ENSG00000137090"
],
"ExpressionAtlas": [
"Q9Y5R6"
],
"GO": [
"GO:0000785",
"GO:0005737",
"GO:0001674",
"GO:0005634",
"GO:0003682",
"GO:0000987",
"GO:0001228",
"GO:0000981",
"GO:0042802",
"GO:0046872",
"GO:0000978",
"GO:1990837",
"GO:0000902",
"GO:0008354",
"GO:0035556",
"GO:0002176",
"GO:0030238",
"GO:0046661",
"GO:0007127",
"GO:0045835",
"GO:0000122",
"GO:0048599",
"GO:2000020",
"GO:0060903",
"GO:0045840",
"GO:0045944",
"GO:1900107",
"GO:0006357",
"GO:0060009",
"GO:0060008",
"GO:0007548",
"GO:0007283"
],
"Gene3D": [
"4.10.1040.10"
],
"InterPro": [
"IPR001275",
"IPR036407",
"IPR026607",
"IPR022114"
],
"PANTHER": [
"PTHR12322",
"PTHR12322:SF70"
],
"Pfam": [
"PF00751",
"PF12374"
],
"SMART": [
"SM00301"
],
"SUPFAM": [
"SSF82927"
],
"PROSITE": [
"PS40000",
"PS50809"
]
},
"citations": [
{
"title": "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators.",
"pubmedID": "10332030",
"doi": "10.1093/hmg/8.6.989"
},
{
"title": "A new submicroscopic deletion that refines the 9p region for sex reversal.",
"pubmedID": "10857744",
"doi": "10.1006/geno.2000.6160"
},
{
"title": "Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis.",
"pubmedID": "16617334",
"doi": "10.1038/sj.cr.7310050"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "DNA sequence and analysis of human chromosome 9.",
"pubmedID": "15164053",
"doi": "10.1038/nature02465"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779.",
"pubmedID": "9718346",
"doi": "10.1086/302016"
},
{
"title": "Evidence for evolutionary conservation of sex-determining genes.",
"pubmedID": "9490411",
"doi": "10.1038/35618"
},
{
"title": "Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer.",
"pubmedID": "20543847",
"doi": "10.1038/ng.607"
},
{
"title": "Identification of de novo copy number variants associated with human disorders of sexual development.",
"pubmedID": "21048976",
"doi": "10.1371/journal.pone.0015392"
},
{
"title": "Scanning of novel cancer/testis proteins by human testis proteomic analysis.",
"pubmedID": "23436708",
"doi": "10.1002/pmic.201200489"
}
],
"sequence": {
"length": 373,
"mass": 39473,
"checksum": "23348B2C4A4733A1",
"modified": {
"$date": {
"$numberLong": "1115683200000"
}
},
"version": 2,
"sequence": "MPNDEAFSKPSTPSEAPHAPGVPPQGRAGGFGKASGALVGAASGSSAGGSSRGGGSGSGASDLGAGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCNLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENNGSNPCLMTECSGTSQPPPASVPTTAASEGRMVIQDIPAVTSRGHVENTPDLVSDSTYYSSFYQPSLFPYYNNLYNCPQYSMALAADSASGEVGNPLGGSPVKNSLRGLPGPYVPGQTGNQWQMKNMENRHAMSSQYRMHSYYPPPSYLGQSVPQFFTFEDAPSYPEARASVFSPPSSQDSGLVSLSSSSPISNKSTKAVLECEPASEPSSFTVTPVIEEDE"
},
"existence": 0,
"relevance": 1,
"proteinID": 1813019202
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}