Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 1816
{
"geneID": 1816,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC098976.2"
]
},
"genePos": {
"start": 5001,
"end": 7376
},
"orientation": true,
"symbol": "DRD5",
"created": {
"$date": {
"$numberLong": "1738333348767"
}
},
"crossReference": {
"enseGeneID": "ENSG00000169676",
"enseRnaID": [
"ENST00000304374.4"
],
"enseProtID": [
"ENSP00000306129.2"
]
},
"chrom": {
"pos": "4",
"type": 1,
"loc": "4p16.1"
},
"desc": "dopamine receptor D5",
"geneType": 5,
"mim": [
{
"id": 126453,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418555",
"term": "G alpha (s) signalling events",
"cat": 13
},
{
"id": "R-HSA-375280",
"term": "Amine ligand-binding receptors",
"cat": 14
},
{
"id": "R-HSA-390651",
"term": "Dopamine receptors",
"cat": 15
},
{
"id": "GO:0001588",
"term": "dopamine neurotransmitter receptor activity, coupled via Gs",
"cat": 0
},
{
"id": "GO:0001588",
"term": "dopamine neurotransmitter receptor activity, coupled via Gs",
"pubMed": [
9457173
],
"cat": 0
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"cat": 0
},
{
"id": "GO:0004952",
"term": "dopamine neurotransmitter receptor activity",
"pubMed": [
1826762
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
32296183
],
"cat": 0
},
{
"id": "GO:0035240",
"term": "dopamine binding",
"pubMed": [
1826762
],
"cat": 0
},
{
"id": "GO:0001963",
"term": "synaptic transmission, dopaminergic",
"pubMed": [
11036203
],
"cat": 1
},
{
"id": "GO:0001975",
"term": "response to amphetamine",
"cat": 1
},
{
"id": "GO:0001992",
"term": "regulation of systemic arterial blood pressure by vasopressin",
"cat": 1
},
{
"id": "GO:0001994",
"term": "norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure",
"cat": 1
},
{
"id": "GO:0006874",
"term": "intracellular calcium ion homeostasis",
"pubMed": [
9457173
],
"cat": 1
},
{
"id": "GO:0007189",
"term": "adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"pubMed": [
11500503
],
"cat": 1
},
{
"id": "GO:0007190",
"term": "activation of adenylate cyclase activity",
"pubMed": [
9457173
],
"cat": 1
},
{
"id": "GO:0007191",
"term": "adenylate cyclase-activating dopamine receptor signaling pathway",
"pubMed": [
1826762,
18403039
],
"cat": 1
},
{
"id": "GO:0007212",
"term": "G protein-coupled dopamine receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007268",
"term": "chemical synaptic transmission",
"pubMed": [
7727453
],
"cat": 1
},
{
"id": "GO:0008306",
"term": "associative learning",
"cat": 1
},
{
"id": "GO:0019226",
"term": "transmission of nerve impulse",
"cat": 1
},
{
"id": "GO:0033861",
"term": "negative regulation of NAD(P)H oxidase activity",
"pubMed": [
16352863
],
"cat": 1
},
{
"id": "GO:0042060",
"term": "wound healing",
"cat": 1
},
{
"id": "GO:0042220",
"term": "response to cocaine",
"cat": 1
},
{
"id": "GO:0043410",
"term": "positive regulation of MAPK cascade",
"cat": 1
},
{
"id": "GO:0045762",
"term": "positive regulation of adenylate cyclase activity",
"pubMed": [
7727453
],
"cat": 1
},
{
"id": "GO:0045776",
"term": "negative regulation of blood pressure",
"cat": 1
},
{
"id": "GO:0045924",
"term": "regulation of female receptivity",
"cat": 1
},
{
"id": "GO:0046960",
"term": "sensitization",
"cat": 1
},
{
"id": "GO:0060158",
"term": "phospholipase C-activating dopamine receptor signaling pathway",
"pubMed": [
9457173
],
"cat": 1
},
{
"id": "GO:0060292",
"term": "long-term synaptic depression",
"cat": 1
},
{
"id": "GO:0071870",
"term": "cellular response to catecholamine stimulus",
"pubMed": [
18403039
],
"cat": 1
},
{
"id": "GO:0071880",
"term": "adenylate cyclase-activating adrenergic receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0072593",
"term": "reactive oxygen species metabolic process",
"pubMed": [
16352863
],
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
10531415,
11500503
],
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
1826762
],
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
9457173
],
"cat": 2
},
{
"id": "GO:0005929",
"term": "cilium",
"pubMed": [
28154160
],
"cat": 2
},
{
"id": "GO:0031526",
"term": "brush border membrane",
"cat": 2
},
{
"id": "GO:0045202",
"term": "synapse",
"cat": 2
},
{
"id": "GO:0060170",
"term": "ciliary membrane",
"pubMed": [
20531939
],
"cat": 2
},
{
"id": "GO:0097730",
"term": "non-motile cilium",
"pubMed": [
20531939
],
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"101060524"
]
}
],
"protein": [
{
"symbol": "DRD5_HUMAN",
"name": "D(1B) dopamine receptor",
"accession": [
"P21918",
"B2R9S3",
"Q8NEQ8"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"606798",
"126453",
"606798"
],
"EMBL": [
"X58454",
"M67439",
"AY136750",
"AK313897",
"CH471069",
"BC009748"
],
"CCDS": [
"CCDS3405.1"
],
"PIR": [
"S15080"
],
"RefSeq": [
"NP_000789.1"
],
"PDB": [
"8IRV"
],
"PDBsum": [
"8IRV"
],
"AlphaFoldDB": [
"P21918"
],
"EMDB": [
"EMD-35687"
],
"SMR": [
"P21918"
],
"BioGRID": [
"108150"
],
"IntAct": [
"P21918"
],
"STRING": [
"9606.ENSP00000306129"
],
"BindingDB": [
"P21918"
],
"ChEMBL": [
"CHEMBL1850"
],
"DrugBank": [
"DB00714",
"DB01238",
"DB14185",
"DB01200",
"DB00248",
"DB01038",
"DB00477",
"DB00568",
"DB00363",
"DB11274",
"DB13345",
"DB00988",
"DB11275",
"DB01049",
"DB00696",
"DB00800",
"DB00458",
"DB00555",
"DB01235",
"DB00589",
"DB00408",
"DB01403",
"DB06148",
"DB08804",
"DB00334",
"DB00715",
"DB01186",
"DB11584",
"DB01224",
"DB09097",
"DB05271",
"DB00726",
"DB00246",
"DB09225",
"DB01624"
],
"DrugCentral": [
"P21918"
],
"GuidetoPHARMACOLOGY": [
"218"
],
"GlyCosmos": [
"P21918"
],
"GlyGen": [
"P21918"
],
"iPTMnet": [
"P21918"
],
"PhosphoSitePlus": [
"P21918"
],
"BioMuta": [
"DRD5"
],
"DMDM": [
"118214"
],
"jPOST": [
"P21918"
],
"MassIVE": [
"P21918"
],
"PaxDb": [
"9606-ENSP00000306129"
],
"PeptideAtlas": [
"P21918"
],
"Antibodypedia": [
"9652"
],
"DNASU": [
"1816"
],
"Ensembl": [
"ENST00000304374.4"
],
"KEGG": [
"hsa:1816"
],
"MANE-Select": [
"ENST00000304374.4"
],
"UCSC": [
"uc003gmb.5"
],
"AGR": [
"HGNC:3026"
],
"CTD": [
"1816"
],
"DisGeNET": [
"1816"
],
"GeneCards": [
"DRD5"
],
"HGNC": [
"HGNC:3026"
],
"HPA": [
"ENSG00000169676"
],
"MalaCards": [
"DRD5"
],
"neXtProt": [
"NX_P21918"
],
"OpenTargets": [
"ENSG00000169676"
],
"PharmGKB": [
"PA148"
],
"VEuPathDB": [
"HostDB:ENSG00000169676"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT00940000157037"
],
"HOGENOM": [
"CLU_009579_11_0_1"
],
"InParanoid": [
"P21918"
],
"OMA": [
"HWHRDKA"
],
"OrthoDB": [
"2900736at2759"
],
"PhylomeDB": [
"P21918"
],
"TreeFam": [
"TF325181"
],
"PathwayCommons": [
"P21918"
],
"Reactome": [
"R-HSA-390651",
"R-HSA-418555"
],
"SignaLink": [
"P21918"
],
"SIGNOR": [
"P21918"
],
"BioGRID-ORCS": [
"1816"
],
"GeneWiki": [
"Dopamine_receptor_D5"
],
"GenomeRNAi": [
"1816"
],
"Pharos": [
"P21918"
],
"PRO": [
"PR:P21918"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P21918"
],
"Bgee": [
"ENSG00000169676"
],
"GO": [
"GO:0031526",
"GO:0060170",
"GO:0005929",
"GO:0097730",
"GO:0005886",
"GO:0045202",
"GO:0035240",
"GO:0004952",
"GO:0001588",
"GO:0004930",
"GO:0007190",
"GO:0071880",
"GO:0007191",
"GO:0007189",
"GO:0008306",
"GO:0071870",
"GO:0007268",
"GO:0007212",
"GO:0006874",
"GO:0060292",
"GO:0045776",
"GO:0033861",
"GO:0001994",
"GO:0060158",
"GO:0045762",
"GO:0043410",
"GO:0072593",
"GO:0045924",
"GO:0001992",
"GO:0001975",
"GO:0042220",
"GO:0046960",
"GO:0001963",
"GO:0019226",
"GO:0042060"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000497",
"IPR000929",
"IPR000276",
"IPR017452"
],
"PANTHER": [
"PTHR24248",
"PTHR24248:SF136"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR00566",
"PR00242",
"PR00237"
],
"SMART": [
"SM01381"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.",
"pubmedID": "1826762",
"doi": "10.1038/350614a0"
},
{
"title": "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.",
"pubmedID": "1833775",
"doi": "10.1073/pnas.88.20.9175"
},
{
"title": "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.",
"pubmedID": "1834671",
"doi": "10.1016/s0021-9258(18)54590-7"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "N-linked glycosylation is required for plasma membrane localization of D5, but not D1, dopamine receptors in transfected mammalian cells.",
"pubmedID": "10531415",
"doi": "10.1124/mol.56.5.1071"
},
{
"title": "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.",
"pubmedID": "11781417",
"doi": "10.1212/wnl.58.1.124"
},
{
"title": "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.",
"pubmedID": "7633397",
"doi": "10.1093/hmg/4.4.507"
},
{
"title": "Characterization of single-nucleotide polymorphisms in coding regions of human genes.",
"pubmedID": "10391209",
"doi": "10.1038/10290"
}
],
"sequence": {
"length": 477,
"mass": 52951,
"checksum": "BACCB85E5A72F9CA",
"modified": {
"$date": {
"$numberLong": "699408000000"
}
},
"version": 2,
"sequence": "MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH"
},
"existence": 0,
"relevance": 1,
"proteinID": 523063562
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}