Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 199974
{
"geneID": 199974,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL450996.2"
]
},
"genePos": {
"start": 47055525,
"end": 47118318
},
"orientation": true,
"symbol": "CYP4Z1",
"created": {
"$date": {
"$numberLong": "1738333350549"
}
},
"crossReference": {
"enseGeneID": "ENSG00000186160",
"enseRnaID": [
"ENST00000334194.4"
],
"enseProtID": [
"ENSP00000334246.3"
]
},
"chrom": {
"pos": "1",
"type": 1,
"loc": "1p33"
},
"desc": "cytochrome P450 family 4 subfamily Z member 1",
"geneType": 5,
"ontology": [
{
"id": "GO:0005506",
"term": "iron ion binding",
"cat": 0
},
{
"id": "GO:0008404",
"term": "arachidonate 14,15-epoxygenase activity",
"pubMed": [
29018033
],
"cat": 0
},
{
"id": "GO:0020037",
"term": "heme binding",
"cat": 0
},
{
"id": "GO:0052722",
"term": "fatty acid in-chain hydroxylase activity",
"pubMed": [
19090726,
29018033
],
"cat": 0
},
{
"id": "GO:0070330",
"term": "aromatase activity",
"cat": 0
},
{
"id": "GO:0019369",
"term": "arachidonate metabolic process",
"pubMed": [
29018033
],
"cat": 1
},
{
"id": "GO:0048252",
"term": "lauric acid metabolic process",
"pubMed": [
19090726,
29018033
],
"cat": 1
},
{
"id": "GO:0005789",
"term": "endoplasmic reticulum membrane",
"pubMed": [
15059886
],
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"163720"
]
}
],
"protein": [
{
"symbol": "CP4Z1_HUMAN",
"name": "CYPIVZ1",
"accession": [
"Q86W10",
"Q5VVE4"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"Rhea": [
"RHEA:17149",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:17150",
"RHEA:45084",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:45085",
"RHEA:66888",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66889",
"RHEA:66872",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66873",
"RHEA:66892",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66893",
"RHEA:39751",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:39752",
"RHEA:66916",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66917",
"RHEA:66880",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66881",
"RHEA:66884",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66885",
"RHEA:66876",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:66877",
"RHEA:49856",
"RHEA-COMP:11964",
"RHEA-COMP:11965",
"RHEA:49857"
],
"ChEBI": [
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30879",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:142491",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18262",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:84921",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18262",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167541",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18262",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167543",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18262",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167542",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:18262",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:76628",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30807",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167544",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30807",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167545",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30807",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167547",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:30807",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:167546",
"CHEBI:15377",
"CHEBI:15378",
"CHEBI:15379",
"CHEBI:32395",
"CHEBI:57618",
"CHEBI:58210",
"CHEBI:131964",
"CHEBI:30413",
"CHEBI:30413",
"CHEBI:18248"
],
"EC": [
"1.14.14.1",
"1.14.14.130"
],
"EMBL": [
"AY262056",
"AY358631",
"AK292175",
"AL450996",
"AL135960",
"AL135960",
"AL450996"
],
"CCDS": [
"CCDS545.1"
],
"RefSeq": [
"NP_835235.1"
],
"AlphaFoldDB": [
"Q86W10"
],
"SMR": [
"Q86W10"
],
"STRING": [
"9606.ENSP00000334246"
],
"BindingDB": [
"Q86W10"
],
"ChEMBL": [
"CHEMBL4523375"
],
"GuidetoPHARMACOLOGY": [
"1352"
],
"iPTMnet": [
"Q86W10"
],
"PhosphoSitePlus": [
"Q86W10"
],
"BioMuta": [
"CYP4Z1"
],
"DMDM": [
"48428052"
],
"jPOST": [
"Q86W10"
],
"MassIVE": [
"Q86W10"
],
"PaxDb": [
"9606-ENSP00000334246"
],
"PeptideAtlas": [
"Q86W10"
],
"ProteomicsDB": [
"70100"
],
"Antibodypedia": [
"32850"
],
"DNASU": [
"199974"
],
"Ensembl": [
"ENST00000334194.4"
],
"KEGG": [
"hsa:199974"
],
"MANE-Select": [
"ENST00000334194.4"
],
"UCSC": [
"uc001cqu.2"
],
"AGR": [
"HGNC:20583"
],
"CTD": [
"199974"
],
"DisGeNET": [
"199974"
],
"GeneCards": [
"CYP4Z1"
],
"HGNC": [
"HGNC:20583"
],
"HPA": [
"ENSG00000186160"
],
"MIM": [
"618953"
],
"neXtProt": [
"NX_Q86W10"
],
"OpenTargets": [
"ENSG00000186160"
],
"PharmGKB": [
"PA134941057"
],
"VEuPathDB": [
"HostDB:ENSG00000186160"
],
"eggNOG": [
"KOG0157"
],
"GeneTree": [
"ENSGT00940000160927"
],
"HOGENOM": [
"CLU_001570_5_1_1"
],
"InParanoid": [
"Q86W10"
],
"OMA": [
"LHHNDLV"
],
"OrthoDB": [
"1611592at2759"
],
"PhylomeDB": [
"Q86W10"
],
"TreeFam": [
"TF105088"
],
"PathwayCommons": [
"Q86W10"
],
"BioGRID-ORCS": [
"199974"
],
"GeneWiki": [
"CYP4Z1"
],
"GenomeRNAi": [
"199974"
],
"Pharos": [
"Q86W10"
],
"PRO": [
"PR:Q86W10"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q86W10"
],
"Bgee": [
"ENSG00000186160"
],
"GO": [
"GO:0005789",
"GO:0008404",
"GO:0070330",
"GO:0052722",
"GO:0020037",
"GO:0005506",
"GO:0019369",
"GO:0048252"
],
"CDD": [
"cd20678"
],
"Gene3D": [
"1.10.630.10"
],
"InterPro": [
"IPR001128",
"IPR017972",
"IPR002401",
"IPR036396",
"IPR050196"
],
"PANTHER": [
"PTHR24291:SF63",
"PTHR24291"
],
"Pfam": [
"PF00067"
],
"PRINTS": [
"PR00463",
"PR00385"
],
"SUPFAM": [
"SSF48264"
],
"PROSITE": [
"PS00086"
]
},
"citations": [
{
"title": "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with overexpression in breast carcinoma.",
"pubmedID": "15059886",
"doi": "10.1158/0008-5472.can-03-0849"
},
{
"title": "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.",
"pubmedID": "12975309",
"doi": "10.1101/gr.1293003"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "The DNA sequence and biological annotation of human chromosome 1.",
"pubmedID": "16710414",
"doi": "10.1038/nature04727"
},
{
"title": "Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.",
"pubmedID": "19090726",
"doi": "10.1515/bc.2009.030"
},
{
"title": "Expression and Functional Characterization of Breast Cancer-Associated Cytochrome P450 4Z1 in Saccharomyces cerevisiae.",
"pubmedID": "29018033",
"doi": "10.1124/dmd.117.078188"
}
],
"sequence": {
"length": 505,
"mass": 59086,
"checksum": "CF23D96739402E86",
"modified": {
"$date": {
"$numberLong": "1054425600000"
}
},
"version": 1,
"sequence": "MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC"
},
"existence": 0,
"relevance": 1,
"proteinID": 4082634434
}
],
"singleCellExpressions": {
"cellSignificanceIndex": [
{
"cell_id": "CL0002326",
"cell_term": "luminal epithelial cell of mammary gland",
"context": "overall",
"pVal": 0.5214188747078965,
"deltaVal": 1,
"csiScore": 7.492748007085918,
"rCsiScore": 13.613285296738622,
"prsScore": 99.949
},
{
"cell_id": "CL0002062",
"cell_term": "pulmonary alveolar type 1 cell",
"context": "overall",
"pVal": 0.5504162237250603,
"deltaVal": 1,
"csiScore": 1.9447507360729985,
"rCsiScore": 11.211932363525852,
"prsScore": 99.7932
}
]
}
}