Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 2692
{
"geneID": 2692,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"CP068271.2"
]
},
"genePos": {
"start": 4933,
"end": 20508
},
"orientation": true,
"symbol": "GHRHR",
"created": {
"$date": {
"$numberLong": "1738333348830"
}
},
"crossReference": {
"enseGeneID": "ENSG00000106128",
"enseRnaID": [
"ENST00000326139.7"
],
"enseProtID": [
"ENSP00000320180.2"
]
},
"chrom": {
"pos": "7",
"type": 1,
"loc": "7p14.3"
},
"desc": "growth hormone releasing hormone receptor",
"geneType": 5,
"mim": [
{
"id": 139191,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373080",
"term": "Class B/2 (Secretin family receptors)",
"cat": 13
},
{
"id": "R-HSA-418555",
"term": "G alpha (s) signalling events",
"cat": 13
},
{
"id": "R-HSA-420092",
"term": "Glucagon-type ligand receptors",
"cat": 14
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
1333056,
7680413
],
"cat": 0
},
{
"id": "GO:0008528",
"term": "G protein-coupled peptide receptor activity",
"cat": 0
},
{
"id": "GO:0016520",
"term": "growth hormone-releasing hormone receptor activity",
"cat": 0
},
{
"id": "GO:0016520",
"term": "growth hormone-releasing hormone receptor activity",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0019838",
"term": "growth factor binding",
"cat": 0
},
{
"id": "GO:0019838",
"term": "growth factor binding",
"pubMed": [
7680413
],
"cat": 0
},
{
"id": "GO:0007166",
"term": "cell surface receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007189",
"term": "adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007189",
"term": "adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"pubMed": [
1333056,
7680413
],
"cat": 1
},
{
"id": "GO:0007595",
"term": "lactation",
"cat": 1
},
{
"id": "GO:0008284",
"term": "positive regulation of cell population proliferation",
"cat": 1
},
{
"id": "GO:0008284",
"term": "positive regulation of cell population proliferation",
"pubMed": [
12867592
],
"cat": 1
},
{
"id": "GO:0008340",
"term": "determination of adult lifespan",
"cat": 1
},
{
"id": "GO:0030252",
"term": "growth hormone secretion",
"cat": 1
},
{
"id": "GO:0032868",
"term": "response to insulin",
"pubMed": [
17356054
],
"cat": 1
},
{
"id": "GO:0032869",
"term": "cellular response to insulin stimulus",
"cat": 1
},
{
"id": "GO:0033143",
"term": "regulation of intracellular steroid hormone receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0040018",
"term": "positive regulation of multicellular organism growth",
"pubMed": [
8528260
],
"cat": 1
},
{
"id": "GO:0042445",
"term": "hormone metabolic process",
"cat": 1
},
{
"id": "GO:0043568",
"term": "positive regulation of insulin-like growth factor receptor signaling pathway",
"pubMed": [
11773624
],
"cat": 1
},
{
"id": "GO:0043627",
"term": "response to estrogen",
"pubMed": [
9482665
],
"cat": 1
},
{
"id": "GO:0048469",
"term": "cell maturation",
"cat": 1
},
{
"id": "GO:0048609",
"term": "multicellular organismal reproductive process",
"pubMed": [
15944917
],
"cat": 1
},
{
"id": "GO:0051246",
"term": "regulation of protein metabolic process",
"cat": 1
},
{
"id": "GO:0051384",
"term": "response to glucocorticoid",
"pubMed": [
9482665
],
"cat": 1
},
{
"id": "GO:0051649",
"term": "establishment of localization in cell",
"cat": 1
},
{
"id": "GO:0060124",
"term": "positive regulation of growth hormone secretion",
"pubMed": [
11773624
],
"cat": 1
},
{
"id": "GO:0060133",
"term": "somatotropin secreting cell development",
"cat": 1
},
{
"id": "GO:0005637",
"term": "nuclear inner membrane",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0005640",
"term": "nuclear outer membrane",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0009986",
"term": "cell surface",
"pubMed": [
1333056
],
"cat": 2
},
{
"id": "GO:0016020",
"term": "membrane",
"pubMed": [
1333056
],
"cat": 2
},
{
"id": "GO:0016363",
"term": "nuclear matrix",
"pubMed": [
10461027
],
"cat": 2
},
{
"id": "GO:0030141",
"term": "secretory granule",
"pubMed": [
10461027
],
"cat": 2
}
],
"protein": [
{
"symbol": "GHRHR_HUMAN",
"name": "Growth hormone-releasing hormone receptor",
"accession": [
"Q02643",
"Q99863"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"618157",
"139191",
"618157"
],
"EMBL": [
"L01406",
"L09237",
"AB065701",
"AY557192",
"AC005155",
"U42225",
"U42222",
"U42223",
"U42224"
],
"CCDS": [
"CCDS5432.1"
],
"PIR": [
"A45363"
],
"RefSeq": [
"NP_000814.2"
],
"PDB": [
"2XDG",
"7CZ5"
],
"PDBsum": [
"2XDG",
"7CZ5"
],
"AlphaFoldDB": [
"Q02643"
],
"EMDB": [
"EMD-30505"
],
"SMR": [
"Q02643"
],
"BioGRID": [
"108959"
],
"STRING": [
"9606.ENSP00000320180"
],
"BindingDB": [
"Q02643"
],
"ChEMBL": [
"CHEMBL2032"
],
"DrugBank": [
"DB00010",
"DB08869"
],
"DrugCentral": [
"Q02643"
],
"GuidetoPHARMACOLOGY": [
"247"
],
"TCDB": [
"9.A.14.4.7"
],
"GlyCosmos": [
"Q02643"
],
"GlyGen": [
"Q02643"
],
"PhosphoSitePlus": [
"Q02643"
],
"BioMuta": [
"GHRHR"
],
"DMDM": [
"3041685"
],
"PaxDb": [
"9606-ENSP00000320180"
],
"PeptideAtlas": [
"Q02643"
],
"Antibodypedia": [
"3360"
],
"DNASU": [
"2692"
],
"Ensembl": [
"ENST00000326139.7"
],
"KEGG": [
"hsa:2692"
],
"MANE-Select": [
"ENST00000326139.7"
],
"UCSC": [
"uc003tbx.4"
],
"AGR": [
"HGNC:4266"
],
"CTD": [
"2692"
],
"DisGeNET": [
"2692"
],
"GeneCards": [
"GHRHR"
],
"HGNC": [
"HGNC:4266"
],
"HPA": [
"ENSG00000106128"
],
"MalaCards": [
"GHRHR"
],
"neXtProt": [
"NX_Q02643"
],
"OpenTargets": [
"ENSG00000106128"
],
"Orphanet": [
"231671"
],
"PharmGKB": [
"PA28676"
],
"VEuPathDB": [
"HostDB:ENSG00000106128"
],
"eggNOG": [
"KOG4564"
],
"GeneTree": [
"ENSGT00940000159858"
],
"InParanoid": [
"Q02643"
],
"OMA": [
"RAWGACI"
],
"OrthoDB": [
"5252868at2759"
],
"PhylomeDB": [
"Q02643"
],
"TreeFam": [
"TF315710"
],
"PathwayCommons": [
"Q02643"
],
"Reactome": [
"R-HSA-418555",
"R-HSA-420092"
],
"SignaLink": [
"Q02643"
],
"BioGRID-ORCS": [
"2692"
],
"ChiTaRS": [
"GHRHR"
],
"EvolutionaryTrace": [
"Q02643"
],
"GeneWiki": [
"Growth-hormone-releasing_hormone_receptor",
"Growth_hormone-releasing_hormone_receptor"
],
"GenomeRNAi": [
"2692"
],
"Pharos": [
"Q02643"
],
"PRO": [
"PR:Q02643"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q02643"
],
"Bgee": [
"ENSG00000106128"
],
"ExpressionAtlas": [
"Q02643"
],
"GO": [
"GO:0009986",
"GO:0005737",
"GO:0016020",
"GO:0005637",
"GO:0016363",
"GO:0005640",
"GO:0005886",
"GO:0030141",
"GO:0008528",
"GO:0004930",
"GO:0019838",
"GO:0016520",
"GO:0017046",
"GO:0007189",
"GO:0048469",
"GO:0007166",
"GO:0032869",
"GO:0008340",
"GO:0051649",
"GO:0030252",
"GO:0042445",
"GO:0007595",
"GO:0048609",
"GO:0008284",
"GO:0060124",
"GO:0043568",
"GO:0040018",
"GO:0033143",
"GO:0051246",
"GO:0043627",
"GO:0051384",
"GO:0032868",
"GO:0060133"
],
"Gene3D": [
"4.10.1240.10",
"1.20.1070.10"
],
"InterPro": [
"IPR050332",
"IPR017981",
"IPR036445",
"IPR001879",
"IPR003288",
"IPR000832",
"IPR017983"
],
"PANTHER": [
"PTHR45620:SF14",
"PTHR45620"
],
"Pfam": [
"PF00002",
"PF02793"
],
"PRINTS": [
"PR01352",
"PR00249"
],
"SMART": [
"SM00008"
],
"SUPFAM": [
"SSF81321",
"SSF111418"
],
"PROSITE": [
"PS00649",
"PS00650",
"PS50227",
"PS50261"
]
},
"citations": [
{
"title": "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.",
"pubmedID": "1333056",
"doi": "10.1210/mend.6.10.1333056"
},
{
"title": "Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone.",
"pubmedID": "7680413",
"doi": "10.1210/mend.7.1.7680413"
},
{
"title": "The DNA sequence of human chromosome 7.",
"pubmedID": "12853948",
"doi": "10.1038/nature01782"
},
{
"title": "Nonsense mutation in the human growth hormone-releasing hormone receptor causes growth failure analogous to the little (lit) mouse.",
"pubmedID": "8528260",
"doi": "10.1038/ng0196-88"
},
{
"title": "Extensive phenotypic analysis of a family with growth hormone (GH) deficiency caused by a mutation in the GH-releasing hormone receptor gene.",
"pubmedID": "9467553",
"doi": "10.1210/jcem.83.2.4528"
},
{
"title": "Three new mutations in the gene for the growth hormone (GH)-releasing hormone receptor in familial isolated GH deficiency type IB.",
"pubmedID": "11232012",
"doi": "10.1210/jcem.86.1.7156"
},
{
"title": "Familial dwarfism due to a novel mutation of the growth hormone-releasing hormone receptor gene.",
"pubmedID": "10084571",
"doi": "10.1210/jcem.84.3.5599"
},
{
"title": "A new missense mutation in the growth hormone-releasing hormone receptor gene in familial isolated GH deficiency.",
"pubmedID": "12534354",
"doi": "10.1530/eje.0.1480025"
},
{
"title": "The consensus coding sequences of human breast and colorectal cancers.",
"pubmedID": "16959974",
"doi": "10.1126/science.1133427"
}
],
"sequence": {
"length": 423,
"mass": 47402,
"checksum": "C9C5E2E7D6649E06",
"modified": {
"$date": {
"$numberLong": "900460800000"
}
},
"version": 2,
"sequence": "MDRRMWGAHVFCVLSPLPTVLGHMHPECDFITQLREDESACLQAAEEMPNTTLGCPATWDGLLCWPTAGSGEWVTLPCPDFFSHFSSESGAVKRDCTITGWSEPFPPYPVACPVPLELLAEEESYFSTVKIIYTVGHSISIVALFVAITILVALRRLHCPRNYVHTQLFTTFILKAGAVFLKDAALFHSDDTDHCSFSTVLCKVSVAASHFATMTNFSWLLAEAVYLNCLLASTSPSSRRAFWWLVLAGWGLPVLFTGTWVSCKLAFEDIACWDLDDTSPYWWIIKGPIVLSVGVNFGLFLNIIRILVRKLEPAQGSLHTQSQYWRLSKSTLFLIPLFGIHYIIFNFLPDNAGLGIRLPLELGLGSFQGFIVAILYCFLNQEVRTEISRKWHGHDPELLPAWRTRAKWTTPSRSAAKVLTSMC"
},
"existence": 0,
"relevance": 1,
"proteinID": 1422532056
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}