Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 2693
{
"geneID": 2693,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC069523.15"
]
},
"genePos": {
"start": 5001,
"end": 10166
},
"orientation": false,
"symbol": "GHSR",
"created": {
"$date": {
"$numberLong": "1738333348830"
}
},
"crossReference": {
"enseGeneID": "ENSG00000121853",
"enseRnaID": [
"ENST00000427970.1"
],
"enseProtID": [
"ENSP00000395344.1"
]
},
"chrom": {
"pos": "3",
"type": 1,
"loc": "3q26.31"
},
"desc": "growth hormone secretagogue receptor",
"geneType": 5,
"mim": [
{
"id": 601898,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-416476",
"term": "G alpha (q) signalling events",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0001616",
"term": "growth hormone secretagogue receptor activity",
"cat": 0
},
{
"id": "GO:0001616",
"term": "growth hormone secretagogue receptor activity",
"pubMed": [
8688086
],
"cat": 0
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"pubMed": [
8688086
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
27129257,
29876881
],
"cat": 0
},
{
"id": "GO:0016520",
"term": "growth hormone-releasing hormone receptor activity",
"pubMed": [
8688086
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"cat": 0
},
{
"id": "GO:0042802",
"term": "identical protein binding",
"pubMed": [
27129257,
29876881
],
"cat": 0
},
{
"id": "GO:0007186",
"term": "G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007186",
"term": "G protein-coupled receptor signaling pathway",
"pubMed": [
8688086
],
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0007611",
"term": "learning or memory",
"cat": 1
},
{
"id": "GO:0008154",
"term": "actin polymerization or depolymerization",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0008343",
"term": "adult feeding behavior",
"cat": 1
},
{
"id": "GO:0009725",
"term": "response to hormone",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0009755",
"term": "hormone-mediated signaling pathway",
"cat": 1
},
{
"id": "GO:0009755",
"term": "hormone-mediated signaling pathway",
"pubMed": [
8688086
],
"cat": 1
},
{
"id": "GO:0010700",
"term": "negative regulation of norepinephrine secretion",
"cat": 1
},
{
"id": "GO:0030252",
"term": "growth hormone secretion",
"pubMed": [
16511605
],
"cat": 1
},
{
"id": "GO:0032094",
"term": "response to food",
"cat": 1
},
{
"id": "GO:0032099",
"term": "negative regulation of appetite",
"cat": 1
},
{
"id": "GO:0032100",
"term": "positive regulation of appetite",
"cat": 1
},
{
"id": "GO:0032354",
"term": "response to follicle-stimulating hormone",
"cat": 1
},
{
"id": "GO:0032355",
"term": "response to estradiol",
"cat": 1
},
{
"id": "GO:0032691",
"term": "negative regulation of interleukin-1 beta production",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0032715",
"term": "negative regulation of interleukin-6 production",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0032720",
"term": "negative regulation of tumor necrosis factor production",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0032869",
"term": "cellular response to insulin stimulus",
"cat": 1
},
{
"id": "GO:0036321",
"term": "ghrelin secretion",
"cat": 1
},
{
"id": "GO:0040018",
"term": "positive regulation of multicellular organism growth",
"pubMed": [
16511605
],
"cat": 1
},
{
"id": "GO:0043134",
"term": "regulation of hindgut contraction",
"cat": 1
},
{
"id": "GO:0043568",
"term": "positive regulation of insulin-like growth factor receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0045923",
"term": "positive regulation of fatty acid metabolic process",
"cat": 1
},
{
"id": "GO:0046676",
"term": "negative regulation of insulin secretion",
"cat": 1
},
{
"id": "GO:0046697",
"term": "decidualization",
"pubMed": [
17494105
],
"cat": 1
},
{
"id": "GO:0048009",
"term": "insulin-like growth factor receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0050728",
"term": "negative regulation of inflammatory response",
"pubMed": [
15232612
],
"cat": 1
},
{
"id": "GO:0051963",
"term": "regulation of synapse assembly",
"cat": 1
},
{
"id": "GO:0051969",
"term": "regulation of transmission of nerve impulse",
"cat": 1
},
{
"id": "GO:0060123",
"term": "regulation of growth hormone secretion",
"cat": 1
},
{
"id": "GO:0060416",
"term": "response to growth hormone",
"cat": 1
},
{
"id": "GO:0071222",
"term": "cellular response to lipopolysaccharide",
"cat": 1
},
{
"id": "GO:0071548",
"term": "response to dexamethasone",
"cat": 1
},
{
"id": "GO:0090327",
"term": "negative regulation of locomotion involved in locomotory behavior",
"cat": 1
},
{
"id": "GO:0097067",
"term": "cellular response to thyroid hormone stimulus",
"cat": 1
},
{
"id": "GO:0098696",
"term": "regulation of neurotransmitter receptor localization to postsynaptic specialization membrane",
"cat": 1
},
{
"id": "GO:0099170",
"term": "postsynaptic modulation of chemical synaptic transmission",
"cat": 1
},
{
"id": "GO:0099175",
"term": "regulation of postsynapse organization",
"cat": 1
},
{
"id": "GO:0120058",
"term": "positive regulation of small intestinal transit",
"cat": 1
},
{
"id": "GO:1902065",
"term": "response to L-glutamate",
"cat": 1
},
{
"id": "GO:1903672",
"term": "positive regulation of sprouting angiogenesis",
"cat": 1
},
{
"id": "GO:1904000",
"term": "positive regulation of eating behavior",
"cat": 1
},
{
"id": "GO:1904349",
"term": "positive regulation of small intestine smooth muscle contraction",
"cat": 1
},
{
"id": "GO:1905333",
"term": "regulation of gastric motility",
"cat": 1
},
{
"id": "GO:1905564",
"term": "positive regulation of vascular endothelial cell proliferation",
"cat": 1
},
{
"id": "GO:1990314",
"term": "cellular response to insulin-like growth factor stimulus",
"cat": 1
},
{
"id": "GO:2000110",
"term": "negative regulation of macrophage apoptotic process",
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0009986",
"term": "cell surface",
"pubMed": [
8688086
],
"cat": 2
},
{
"id": "GO:0043005",
"term": "neuron projection",
"pubMed": [
12890514
],
"cat": 2
},
{
"id": "GO:0045121",
"term": "membrane raft",
"pubMed": [
15232612
],
"cat": 2
},
{
"id": "GO:0097060",
"term": "synaptic membrane",
"cat": 2
},
{
"id": "GO:0098685",
"term": "Schaffer collateral - CA1 synapse",
"cat": 2
},
{
"id": "GO:0098794",
"term": "postsynapse",
"cat": 2
},
{
"id": "GO:0098978",
"term": "glutamatergic synapse",
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"442206"
]
}
],
"protein": [
{
"symbol": "GHSR_HUMAN",
"name": "Growth hormone secretagogue receptor type 1",
"accession": [
"Q92847",
"Q14D12",
"Q6ISR8",
"Q92848",
"Q96RJ7"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"615925",
"601898",
"615925"
],
"EMBL": [
"U60179",
"U60181",
"AF369786",
"AF369786",
"AY429112",
"AY322544",
"CH471052",
"BC069068",
"BC069374",
"BC113547"
],
"CCDS": [
"CCDS3218.1",
"CCDS46959.1"
],
"RefSeq": [
"NP_004113.1",
"NP_940799.1"
],
"PDB": [
"6KO5",
"7F9Y",
"7F9Z",
"7NA7",
"7NA8",
"7W2Z"
],
"PDBsum": [
"6KO5",
"7F9Y",
"7F9Z",
"7NA7",
"7NA8",
"7W2Z"
],
"AlphaFoldDB": [
"Q92847"
],
"EMDB": [
"EMD-24267",
"EMD-24268",
"EMD-31501",
"EMD-32268"
],
"SMR": [
"Q92847"
],
"BioGRID": [
"108960"
],
"IntAct": [
"Q92847"
],
"STRING": [
"9606.ENSP00000241256"
],
"BindingDB": [
"Q92847"
],
"ChEMBL": [
"CHEMBL4616"
],
"DrugBank": [
"DB15488",
"DB13074",
"DB12128"
],
"DrugCentral": [
"Q92847"
],
"GuidetoPHARMACOLOGY": [
"246"
],
"TCDB": [
"9.A.14.1.6"
],
"GlyCosmos": [
"Q92847"
],
"GlyGen": [
"Q92847"
],
"iPTMnet": [
"Q92847"
],
"PhosphoSitePlus": [
"Q92847"
],
"BioMuta": [
"GHSR"
],
"DMDM": [
"2494998"
],
"PaxDb": [
"9606-ENSP00000241256"
],
"PeptideAtlas": [
"Q92847"
],
"ProteomicsDB": [
"75541",
"75542"
],
"Antibodypedia": [
"3248"
],
"DNASU": [
"2693"
],
"Ensembl": [
"ENST00000241256.3",
"ENST00000427970.1"
],
"KEGG": [
"hsa:2693"
],
"MANE-Select": [
"ENST00000241256.3"
],
"UCSC": [
"uc003fib.3"
],
"AGR": [
"HGNC:4267"
],
"CTD": [
"2693"
],
"DisGeNET": [
"2693"
],
"GeneCards": [
"GHSR"
],
"HGNC": [
"HGNC:4267"
],
"HPA": [
"ENSG00000121853"
],
"MalaCards": [
"GHSR"
],
"neXtProt": [
"NX_Q92847"
],
"OpenTargets": [
"ENSG00000121853"
],
"Orphanet": [
"314811"
],
"PharmGKB": [
"PA28677"
],
"VEuPathDB": [
"HostDB:ENSG00000121853"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT01120000271823"
],
"HOGENOM": [
"CLU_009579_6_5_1"
],
"InParanoid": [
"Q92847"
],
"OMA": [
"KYRMAAC"
],
"OrthoDB": [
"3471593at2759"
],
"PhylomeDB": [
"Q92847"
],
"TreeFam": [
"TF332184"
],
"PathwayCommons": [
"Q92847"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-416476"
],
"SignaLink": [
"Q92847"
],
"SIGNOR": [
"Q92847"
],
"BioGRID-ORCS": [
"2693"
],
"GeneWiki": [
"Growth_hormone_secretagogue_receptor"
],
"GenomeRNAi": [
"2693"
],
"Pharos": [
"Q92847"
],
"PRO": [
"PR:Q92847"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q92847"
],
"Bgee": [
"ENSG00000121853"
],
"GO": [
"GO:0009986",
"GO:0098978",
"GO:0045121",
"GO:0043005",
"GO:0005886",
"GO:0098794",
"GO:0098685",
"GO:0097060",
"GO:0004930",
"GO:0001616",
"GO:0016520",
"GO:0042802",
"GO:0017046",
"GO:0008154",
"GO:0008343",
"GO:0032869",
"GO:1990314",
"GO:0071222",
"GO:0097067",
"GO:0046697",
"GO:0007186",
"GO:0036321",
"GO:0030252",
"GO:0009755",
"GO:0048009",
"GO:0007611",
"GO:0032099",
"GO:0050728",
"GO:0046676",
"GO:0032691",
"GO:0032715",
"GO:0090327",
"GO:2000110",
"GO:0010700",
"GO:0032720",
"GO:0032100",
"GO:1904000",
"GO:0045923",
"GO:0043568",
"GO:0040018",
"GO:0120058",
"GO:1904349",
"GO:1903672",
"GO:1905564",
"GO:0099170",
"GO:1905333",
"GO:0060123",
"GO:0043134",
"GO:0098696",
"GO:0099175",
"GO:0051963",
"GO:0051969",
"GO:0071548",
"GO:0032355",
"GO:0032354",
"GO:0032094",
"GO:0060416",
"GO:0009725",
"GO:1902065",
"GO:0007283"
],
"CDD": [
"cd15131"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR003905",
"IPR000276",
"IPR017452"
],
"PANTHER": [
"PTHR24243",
"PTHR24243:SF7"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR01417",
"PR00237"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "A receptor in pituitary and hypothalamus that functions in growth hormone release.",
"pubmedID": "8688086",
"doi": "10.1126/science.273.5277.974"
},
{
"title": "Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor.",
"pubmedID": "11356716",
"doi": "10.1210/endo.142.6.8184"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "Growth hormone secretagogue receptor family members and ligands.",
"pubmedID": "11322507",
"doi": "10.1385/endo:14:1:009"
},
{
"title": "Ghrelin is a growth-hormone-releasing acylated peptide from stomach.",
"pubmedID": "10604470",
"doi": "10.1038/45230"
},
{
"title": "Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature.",
"pubmedID": "16511605",
"doi": "10.1172/jci25303"
},
{
"title": "Recessive isolated growth hormone deficiency and mutations in the ghrelin receptor.",
"pubmedID": "19789204",
"doi": "10.1210/jc.2009-1327"
}
],
"sequence": {
"length": 366,
"mass": 41329,
"checksum": "D1B62710DA9DC0C6",
"modified": {
"$date": {
"$numberLong": "854755200000"
}
},
"version": 1,
"sequence": "MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT"
},
"existence": 0,
"relevance": 1,
"proteinID": 3198791836
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}