Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 4105
{
"geneID": 4105,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC244102.3"
]
},
"genePos": {
"start": 151032689,
"end": 151036258
},
"orientation": false,
"symbol": "MAGEA6",
"created": {
"$date": {
"$numberLong": "1738333348982"
}
},
"crossReference": {
"enseGeneID": "ENSG00000197172",
"enseRnaID": [
"ENST00000329342.10"
],
"enseProtID": [
"ENSP00000329199.5"
]
},
"chrom": {
"loc": "Xq28"
},
"desc": "MAGE family member A6",
"geneType": 5,
"mim": [
{
"id": 300176,
"relation": 0
}
],
"ontology": [
{
"id": "GO:0003674",
"term": "molecular_function",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
20864041,
21516116,
25416956,
25910212,
26871637,
31515488,
32296183,
32814053
],
"cat": 0
},
{
"id": "GO:0042826",
"term": "histone deacetylase binding",
"cat": 0
},
{
"id": "GO:0000122",
"term": "negative regulation of transcription by RNA polymerase II",
"cat": 1
},
{
"id": "GO:0010507",
"term": "negative regulation of autophagy",
"pubMed": [
31267705
],
"cat": 1
},
{
"id": "GO:0005575",
"term": "cellular_component",
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"cat": 2
}
],
"protein": [
{
"symbol": "MAGA6_HUMAN",
"name": "Cancer/testis antigen 1.6",
"accession": [
"P43360",
"A8IF93",
"Q6NW44"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"U10691",
"U10339",
"D32076",
"EU161101",
"BX640600",
"BC041599",
"BC067731"
],
"CCDS": [
"CCDS76050.1"
],
"PIR": [
"JC2360"
],
"RefSeq": [
"NP_005354.1",
"NP_787064.1"
],
"AlphaFoldDB": [
"P43360"
],
"SMR": [
"P43360"
],
"BioGRID": [
"110279"
],
"IntAct": [
"P43360"
],
"MINT": [
"P43360"
],
"STRING": [
"9606.ENSP00000480637"
],
"iPTMnet": [
"P43360"
],
"PhosphoSitePlus": [
"P43360"
],
"BioMuta": [
"MAGEA6"
],
"DMDM": [
"1170860"
],
"jPOST": [
"P43360"
],
"MassIVE": [
"P43360"
],
"PaxDb": [
"9606-ENSP00000480637"
],
"PeptideAtlas": [
"P43360"
],
"ProteomicsDB": [
"55622"
],
"Antibodypedia": [
"30735"
],
"DNASU": [
"4105"
],
"Ensembl": [
"ENST00000329342.10",
"ENST00000616035.4",
"ENST00000710006.1",
"ENST00000710007.1"
],
"KEGG": [
"hsa:4105"
],
"MANE-Select": [
"ENST00000329342.10"
],
"UCSC": [
"uc033fan.1"
],
"AGR": [
"HGNC:6804"
],
"CTD": [
"4105"
],
"DisGeNET": [
"4105"
],
"GeneCards": [
"MAGEA6"
],
"HGNC": [
"HGNC:6804"
],
"HPA": [
"ENSG00000197172"
],
"MIM": [
"300176"
],
"neXtProt": [
"NX_P43360"
],
"OpenTargets": [
"ENSG00000197172"
],
"PharmGKB": [
"PA30550"
],
"VEuPathDB": [
"HostDB:ENSG00000197172"
],
"eggNOG": [
"KOG4562"
],
"GeneTree": [
"ENSGT00940000164672"
],
"HOGENOM": [
"CLU_039582_1_2_1"
],
"InParanoid": [
"P43360"
],
"OMA": [
"SPLHEWA"
],
"OrthoDB": [
"3128316at2759"
],
"PhylomeDB": [
"P43360"
],
"TreeFam": [
"TF328505"
],
"PathwayCommons": [
"P43360"
],
"SignaLink": [
"P43360"
],
"SIGNOR": [
"P43360"
],
"BioGRID-ORCS": [
"4105"
],
"GenomeRNAi": [
"4105"
],
"Pharos": [
"P43360"
],
"PRO": [
"PR:P43360"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P43360"
],
"Bgee": [
"ENSG00000197172"
],
"ExpressionAtlas": [
"P43360"
],
"GO": [
"GO:0005634",
"GO:0042826",
"GO:0010507",
"GO:0000122"
],
"Gene3D": [
"1.10.10.1200",
"1.10.10.1210"
],
"InterPro": [
"IPR037445",
"IPR021072",
"IPR041898",
"IPR041899",
"IPR002190"
],
"PANTHER": [
"PTHR11736:SF60",
"PTHR11736"
],
"Pfam": [
"PF01454",
"PF12440"
],
"SMART": [
"SM01373",
"SM01392"
],
"PROSITE": [
"PS50838"
]
},
"citations": [
{
"title": "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.",
"pubmedID": "7927540",
"doi": "10.1007/bf01246677"
},
{
"title": "Cloning and analysis of MAGE-1-related genes.",
"pubmedID": "8037761",
"doi": "10.1006/bbrc.1994.1963"
},
{
"title": "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens.",
"pubmedID": "7642112",
"doi": "10.1016/0378-1119(94)00680-q"
},
{
"title": "The full-ORF clone resource of the German cDNA consortium.",
"pubmedID": "17974005",
"doi": "10.1186/1471-2164-8-399"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines.",
"pubmedID": "17942928",
"doi": "10.1158/0008-5472.can-07-1478"
},
{
"title": "MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases.",
"pubmedID": "20864041",
"doi": "10.1016/j.molcel.2010.08.029"
},
{
"title": "Regulation of MAGE-A3/6 by the CRL4-DCAF12 ubiquitin ligase and nutrient availability.",
"pubmedID": "31267705",
"doi": "10.15252/embr.201847352"
},
{
"title": "Terminal osseous dysplasia is caused by a single recurrent mutation in the FLNA gene.",
"pubmedID": "20598277",
"doi": "10.1016/j.ajhg.2010.06.008"
}
],
"sequence": {
"length": 314,
"mass": 34891,
"checksum": "29B83C7FA6E50263",
"modified": {
"$date": {
"$numberLong": "815184000000"
}
},
"version": 1,
"sequence": "MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAKLVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASDSLQLVFGIELMEVDPIGHVYIFATCLGLSYDGLLGDNQIMPKTGFLIIILAIIAKEGDCAPEEKIWEELSVLEVFEGREDSIFGDPKKLLTQYFVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHMVKISGGPRISYPLLHEWALREGEE"
},
"existence": 0,
"relevance": 1,
"proteinID": 1223572214
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}