Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 5619
{
"geneID": 5619,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC009121.8"
]
},
"genePos": {
"start": 11280841,
"end": 11281330
},
"orientation": true,
"symbol": "PRM1",
"created": {
"$date": {
"$numberLong": "1738333349104"
}
},
"crossReference": {
"enseGeneID": "ENSG00000175646",
"enseRnaID": [
"ENST00000312511.4"
],
"enseProtID": [
"ENSP00000310515.3"
]
},
"chrom": {
"pos": "16",
"type": 1,
"loc": "16p13.13"
},
"desc": "protamine 1",
"geneType": 5,
"mim": [
{
"id": 182880,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-1266738",
"term": "Developmental Biology",
"cat": 10
},
{
"id": "R-HSA-9816359",
"term": "Maternal to zygotic transition (MZT)",
"cat": 11
},
{
"id": "R-HSA-9821993",
"term": "Replacement of protamines by nucleosomes in the male pronucleus",
"cat": 12
},
{
"id": "GO:0003677",
"term": "DNA binding",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
32296183
],
"cat": 0
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"pubMed": [
2081589
],
"cat": 1
},
{
"id": "GO:0030261",
"term": "chromosome condensation",
"cat": 1
},
{
"id": "GO:0035092",
"term": "sperm DNA condensation",
"cat": 1
},
{
"id": "GO:0051276",
"term": "chromosome organization",
"pubMed": [
2081589
],
"cat": 1
},
{
"id": "GO:0000786",
"term": "nucleosome",
"cat": 2
},
{
"id": "GO:0005654",
"term": "nucleoplasm",
"cat": 2
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
}
],
"protein": [
{
"symbol": "HSP1_HUMAN",
"name": "Sperm protamine P1",
"accession": [
"P04553"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"Z46940",
"M60331",
"M29706",
"Y00443",
"U15422",
"S68144",
"AF215707",
"BT006746",
"BC003673"
],
"CCDS": [
"CCDS10547.1"
],
"PIR": [
"A38515"
],
"RefSeq": [
"NP_002752.1"
],
"AlphaFoldDB": [
"P04553"
],
"BioGRID": [
"111604"
],
"IntAct": [
"P04553"
],
"STRING": [
"9606.ENSP00000310515"
],
"iPTMnet": [
"P04553"
],
"PhosphoSitePlus": [
"P04553"
],
"BioMuta": [
"PRM1"
],
"DMDM": [
"123691"
],
"PaxDb": [
"9606-ENSP00000310515"
],
"ProteomicsDB": [
"51716"
],
"Antibodypedia": [
"24690"
],
"DNASU": [
"5619"
],
"Ensembl": [
"ENST00000312511.4"
],
"KEGG": [
"hsa:5619"
],
"MANE-Select": [
"ENST00000312511.4"
],
"AGR": [
"HGNC:9447"
],
"CTD": [
"5619"
],
"DisGeNET": [
"5619"
],
"GeneCards": [
"PRM1"
],
"HGNC": [
"HGNC:9447"
],
"HPA": [
"ENSG00000175646"
],
"MIM": [
"182880"
],
"neXtProt": [
"NX_P04553"
],
"OpenTargets": [
"ENSG00000175646"
],
"PharmGKB": [
"PA33792"
],
"VEuPathDB": [
"HostDB:ENSG00000175646"
],
"GeneTree": [
"ENSGT00950000184850"
],
"HOGENOM": [
"CLU_214580_2_0_1"
],
"InParanoid": [
"P04553"
],
"OMA": [
"MARYICC"
],
"PathwayCommons": [
"P04553"
],
"Reactome": [
"R-HSA-9821993"
],
"SignaLink": [
"P04553"
],
"BioGRID-ORCS": [
"5619"
],
"ChiTaRS": [
"PRM1"
],
"GenomeRNAi": [
"5619"
],
"Pharos": [
"P04553"
],
"PRO": [
"PR:P04553"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P04553"
],
"Bgee": [
"ENSG00000175646"
],
"ExpressionAtlas": [
"P04553"
],
"GO": [
"GO:0005829",
"GO:0005654",
"GO:0000786",
"GO:0003677",
"GO:0030261",
"GO:0051276",
"GO:0035092",
"GO:0007283"
],
"InterPro": [
"IPR000221"
],
"Pfam": [
"PF00260"
],
"PROSITE": [
"PS00048"
]
},
"citations": [
{
"title": "Genomic sequences of human protamines whose genes, PRM1 and PRM2, are clustered.",
"pubmedID": "2081589",
"doi": "10.1016/0888-7543(90)90234-l"
},
{
"title": "Chromosomal localization and structure of the human P1 protamine gene.",
"pubmedID": "2613245",
"doi": "10.1016/0888-7543(89)90036-0"
},
{
"title": "The nucleotide sequence of a human protamine 1 cDNA.",
"pubmedID": "3658707",
"doi": "10.1093/nar/15.18.7639"
},
{
"title": "Characterization of a human locus in transition.",
"pubmedID": "7983046",
"doi": "10.1016/s0021-9258(18)47391-7"
},
{
"title": "Direct sequencing of the human protamine P1 gene and application in forensic medicine.",
"pubmedID": "8263493"
},
{
"title": "Rapid evolution of male reproductive genes in the descent of man.",
"pubmedID": "10659848",
"doi": "10.1038/35002070"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "The amino acid sequence of human sperm protamine P1.",
"pubmedID": "4027356",
"doi": "10.1007/bf01116555"
},
{
"title": "Isolation and amino-acid sequence analysis of human sperm protamines P1 and P2. Occurrence of two forms of protamine P2.",
"pubmedID": "3527226",
"doi": "10.1515/bchm3.1986.367.1.515"
},
{
"title": "SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1.",
"pubmedID": "10390541",
"doi": "10.1093/nar/27.14.2972"
}
],
"sequence": {
"length": 51,
"mass": 6823,
"checksum": "4A5C6A92C713C33D",
"modified": {
"$date": {
"$numberLong": "1169510400000"
}
},
"version": 2,
"sequence": "MARYRCCRSQSRSRYYRQRQRSRRRRRRSCQTRRRAMRCCRPRYRPRCRRH"
},
"existence": 0,
"relevance": 1,
"proteinID": 3021740658
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}