Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 6406
{
"geneID": 6406,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049767.12"
]
},
"genePos": {
"start": 45207033,
"end": 45209768
},
"orientation": true,
"symbol": "SEMG1",
"created": {
"$date": {
"$numberLong": "1738333349159"
}
},
"crossReference": {
"enseGeneID": "ENSG00000124233",
"enseRnaID": [
"ENST00000372781.4"
],
"enseProtID": [
"ENSP00000361867.3"
]
},
"chrom": {
"pos": "20",
"type": 1,
"loc": "20q13.12"
},
"desc": "semenogelin 1",
"geneType": 5,
"mim": [
{
"id": 182140,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-168256",
"term": "Immune System",
"cat": 10
},
{
"id": "R-HSA-392499",
"term": "Metabolism of proteins",
"cat": 10
},
{
"id": "R-HSA-168249",
"term": "Innate Immune System",
"cat": 11
},
{
"id": "R-HSA-977225",
"term": "Amyloid fiber formation",
"cat": 11
},
{
"id": "R-HSA-6803157",
"term": "Antimicrobial peptides",
"cat": 12
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
8665956,
15590901,
19889947,
28514442,
32296183,
33961781
],
"cat": 0
},
{
"id": "GO:0008270",
"term": "zinc ion binding",
"pubMed": [
15563730
],
"cat": 0
},
{
"id": "GO:0007320",
"term": "insemination",
"pubMed": [
2912989
],
"cat": 1
},
{
"id": "GO:0019731",
"term": "antibacterial humoral response",
"pubMed": [
18714013
],
"cat": 1
},
{
"id": "GO:0031640",
"term": "killing of cells of another organism",
"pubMed": [
18314226
],
"cat": 1
},
{
"id": "GO:0048240",
"term": "sperm capacitation",
"cat": 1
},
{
"id": "GO:0050817",
"term": "coagulation",
"pubMed": [
8665956
],
"cat": 1
},
{
"id": "GO:0061844",
"term": "antimicrobial humoral immune response mediated by antimicrobial peptide",
"pubMed": [
18314226
],
"cat": 1
},
{
"id": "GO:0090281",
"term": "negative regulation of calcium ion import",
"pubMed": [
22075473
],
"cat": 1
},
{
"id": "GO:1900005",
"term": "positive regulation of serine-type endopeptidase activity",
"pubMed": [
15563730
],
"cat": 1
},
{
"id": "GO:1901318",
"term": "negative regulation of flagellated sperm motility",
"pubMed": [
22075473
],
"cat": 1
},
{
"id": "GO:1901318",
"term": "negative regulation of flagellated sperm motility",
"pubMed": [
19889947
],
"cat": 1
},
{
"id": "GO:0005576",
"term": "extracellular region",
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
2912989,
8665951,
8665956,
17567961,
18314226,
18714013
],
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
1517240
],
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
21630459
],
"cat": 2
},
{
"id": "GO:0032991",
"term": "protein-containing complex",
"pubMed": [
17567961
],
"cat": 2
},
{
"id": "GO:0070062",
"term": "extracellular exosome",
"pubMed": [
23533145
],
"cat": 2
}
],
"geneRelations": [
{
"type": 1,
"similarGenes": [
"6407"
]
}
],
"protein": [
{
"symbol": "SEMG1_HUMAN",
"name": "Semenogelin-1",
"accession": [
"P04279",
"Q53ZV0",
"Q53ZV1",
"Q53ZV2",
"Q6X4I9",
"Q6Y809",
"Q6Y822",
"Q6Y823",
"Q86U64",
"Q96QM3"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"J04440",
"Z47556",
"M81650",
"AY256465",
"AY256466",
"AY256467",
"AY256468",
"AY256469",
"BT007177",
"AL049767",
"CH471077",
"BC007096",
"BC055416",
"AY174423",
"AY174424",
"AY174437"
],
"CCDS": [
"CCDS13345.1"
],
"PIR": [
"B43412"
],
"RefSeq": [
"NP_002998.1"
],
"PDB": [
"7ZRF",
"7ZRO",
"8BOO",
"8BVZ"
],
"PDBsum": [
"7ZRF",
"7ZRO",
"8BOO",
"8BVZ"
],
"AlphaFoldDB": [
"P04279"
],
"SMR": [
"P04279"
],
"BioGRID": [
"112306"
],
"IntAct": [
"P04279"
],
"MINT": [
"P04279"
],
"STRING": [
"9606.ENSP00000361867"
],
"DrugBank": [
"DB01593",
"DB14487",
"DB14533",
"DB14548"
],
"iPTMnet": [
"P04279"
],
"PhosphoSitePlus": [
"P04279"
],
"BioMuta": [
"SEMG1"
],
"DMDM": [
"134426"
],
"jPOST": [
"P04279"
],
"MassIVE": [
"P04279"
],
"PaxDb": [
"9606-ENSP00000361867"
],
"PeptideAtlas": [
"P04279"
],
"ProteomicsDB": [
"51699",
"51700"
],
"Pumba": [
"P04279"
],
"Antibodypedia": [
"12686"
],
"DNASU": [
"6406"
],
"Ensembl": [
"ENST00000372781.4"
],
"KEGG": [
"hsa:6406"
],
"MANE-Select": [
"ENST00000372781.4"
],
"UCSC": [
"uc002xni.3"
],
"AGR": [
"HGNC:10742"
],
"CTD": [
"6406"
],
"DisGeNET": [
"6406"
],
"GeneCards": [
"SEMG1"
],
"HGNC": [
"HGNC:10742"
],
"HPA": [
"ENSG00000124233"
],
"MIM": [
"182140"
],
"neXtProt": [
"NX_P04279"
],
"OpenTargets": [
"ENSG00000124233"
],
"PharmGKB": [
"PA35664"
],
"VEuPathDB": [
"HostDB:ENSG00000124233"
],
"eggNOG": [
"ENOG502T80H"
],
"GeneTree": [
"ENSGT00940000162560"
],
"HOGENOM": [
"CLU_034710_0_0_1"
],
"InParanoid": [
"P04279"
],
"OMA": [
"QRHNYDR"
],
"OrthoDB": [
"4729048at2759"
],
"PhylomeDB": [
"P04279"
],
"TreeFam": [
"TF342360"
],
"PathwayCommons": [
"P04279"
],
"Reactome": [
"R-HSA-6803157",
"R-HSA-977225"
],
"SignaLink": [
"P04279"
],
"BioGRID-ORCS": [
"6406"
],
"ChiTaRS": [
"SEMG1"
],
"GeneWiki": [
"Semenogelin_I"
],
"GenomeRNAi": [
"6406"
],
"Pharos": [
"P04279"
],
"PRO": [
"PR:P04279"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P04279"
],
"Bgee": [
"ENSG00000124233"
],
"GO": [
"GO:0070062",
"GO:0005576",
"GO:0005615",
"GO:0005634",
"GO:0032991",
"GO:0008270",
"GO:0019731",
"GO:0061844",
"GO:0050817",
"GO:0007320",
"GO:0031640",
"GO:0090281",
"GO:1901318",
"GO:1900005",
"GO:0048240"
],
"InterPro": [
"IPR008836"
],
"PANTHER": [
"PTHR10547:SF4",
"PTHR10547"
],
"Pfam": [
"PF05474"
]
},
"citations": [
{
"title": "Semenogelin, the predominant protein in human semen. Primary structure and identification of closely related proteins in the male accessory sex glands and on the spermatozoa.",
"pubmedID": "2912989",
"doi": "10.1016/s0021-9258(18)94272-9"
},
{
"title": "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.",
"pubmedID": "1517240",
"doi": "10.1016/s0021-9258(19)37155-8"
},
{
"title": "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.",
"pubmedID": "14629036",
"doi": "10.1007/s00239-003-2474-x"
},
{
"title": "The DNA sequence and comparative analysis of human chromosome 20.",
"pubmedID": "11780052",
"doi": "10.1038/414865a"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I.",
"pubmedID": "14562960",
"doi": "10.1007/s00239-002-2463-0"
},
{
"title": "Amino acid sequence of the predominant basic protein in human seminal plasma.",
"pubmedID": "3972122",
"doi": "10.1016/0014-5793(85)81179-0"
},
{
"title": "Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity.",
"pubmedID": "6698208",
"doi": "10.1016/0014-5793(84)80840-6"
},
{
"title": "Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.",
"pubmedID": "6422553",
"doi": "10.1126/science.6422553"
},
{
"title": "Isolation and structure determination of two peptides occurring in human seminal plasma.",
"pubmedID": "2757795"
},
{
"title": "Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen.",
"pubmedID": "8444163",
"doi": "10.1111/j.1432-1033.1993.tb17629.x"
},
{
"title": "Human seminal alpha inhibins: isolation, characterization, and structure.",
"pubmedID": "3889920",
"doi": "10.1073/pnas.82.12.4041"
},
{
"title": "Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein.",
"pubmedID": "10412373",
"doi": "10.1007/s000180050346"
},
{
"title": "Association of eppin with semenogelin on human spermatozoa.",
"pubmedID": "15590901",
"doi": "10.1095/biolreprod.104.036483"
},
{
"title": "Characterization of an eppin protein complex from human semen and spermatozoa.",
"pubmedID": "17567961",
"doi": "10.1095/biolreprod.107.060194"
},
{
"title": "Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.",
"pubmedID": "19889947",
"doi": "10.1095/biolreprod.109.081331"
}
],
"sequence": {
"length": 462,
"mass": 52131,
"checksum": "760F48EFCF2FA702",
"modified": {
"$date": {
"$numberLong": "631152000000"
}
},
"version": 2,
"sequence": "MKPNIIFVLSLLLILEKQAAVMGQKGGSKGRLPSEFSQFPHGQKGQHYSGQKGKQQTESKGSFSIQYTYHVDANDHDQSRKSQQYDLNALHKTTKSQRHLGGSQQLLHNKQEGRDHDKSKGHFHRVVIHHKGGKAHRGTQNPSQDQGNSPSGKGISSQYSNTEERLWVHGLSKEQTSVSGAQKGRKQGGSQSSYVLQTEELVANKQQRETKNSHQNKGHYQNVVEVREEHSSKVQTSLCPAHQDKLQHGSKDIFSTQDELLVYNKNQHQTKNLNQDQQHGRKANKISYQSSSTEERRLHYGENGVQKDVSQSSIYSQTEEKAQGKSQKQITIPSQEQEHSQKANKISYQSSSTEERRLHYGENGVQKDVSQRSIYSQTEKLVAGKSQIQAPNPKQEPWHGENAKGESGQSTNREQDLLSHEQKGRHQHGSHGGLDIVIIEQEDDSDRHLAQHLNNDRNPLFT"
},
"existence": 0,
"relevance": 1,
"proteinID": 931909807
}
],
"mRNAExpressions": {
"proteinAtlas": [
{
"l": "Granulocytes",
"c": "eosinophil",
"e": 26.9
}
]
},
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}