Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 6407
{
"geneID": 6407,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049767.12"
]
},
"genePos": {
"start": 45221373,
"end": 45224458
},
"orientation": true,
"symbol": "SEMG2",
"created": {
"$date": {
"$numberLong": "1738333349159"
}
},
"crossReference": {
"enseGeneID": "ENSG00000124157",
"enseRnaID": [
"ENST00000372769.4"
],
"enseProtID": [
"ENSP00000361855.3"
]
},
"chrom": {
"pos": "20",
"type": 1,
"loc": "20q13.12"
},
"desc": "semenogelin 2",
"geneType": 5,
"mim": [
{
"id": 182141,
"relation": 0
}
],
"ontology": [
{
"id": "GO:0002020",
"term": "protease binding",
"pubMed": [
8665956
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
8665956
],
"cat": 0
},
{
"id": "GO:0008270",
"term": "zinc ion binding",
"pubMed": [
15563730
],
"cat": 0
},
{
"id": "GO:0019731",
"term": "antibacterial humoral response",
"pubMed": [
18714013
],
"cat": 1
},
{
"id": "GO:0048240",
"term": "sperm capacitation",
"cat": 1
},
{
"id": "GO:0050817",
"term": "coagulation",
"pubMed": [
8665956
],
"cat": 1
},
{
"id": "GO:1900005",
"term": "positive regulation of serine-type endopeptidase activity",
"pubMed": [
15563730
],
"cat": 1
},
{
"id": "GO:1901318",
"term": "negative regulation of flagellated sperm motility",
"cat": 1
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
8665951,
8665956,
18714013
],
"cat": 2
},
{
"id": "GO:0005615",
"term": "extracellular space",
"pubMed": [
1517240
],
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
21630459
],
"cat": 2
},
{
"id": "GO:0070062",
"term": "extracellular exosome",
"pubMed": [
23533145
],
"cat": 2
}
],
"geneRelations": [
{
"type": 1,
"similarGenes": [
"6406"
]
}
],
"protein": [
{
"symbol": "SEMG2_HUMAN",
"name": "Semenogelin-2",
"accession": [
"Q02383",
"Q53ZU2",
"Q6X2M5",
"Q6X2M6"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"M81652",
"M81651",
"Z47556",
"AY259284",
"AY259285",
"AY259286",
"AL049767",
"CH471077"
],
"CCDS": [
"CCDS13346.1"
],
"PIR": [
"A43412"
],
"RefSeq": [
"NP_002999.1"
],
"AlphaFoldDB": [
"Q02383"
],
"SMR": [
"Q02383"
],
"BioGRID": [
"112307"
],
"IntAct": [
"Q02383"
],
"MINT": [
"Q02383"
],
"STRING": [
"9606.ENSP00000361855"
],
"DrugBank": [
"DB14533",
"DB14548"
],
"GlyConnect": [
"2012"
],
"GlyCosmos": [
"Q02383"
],
"GlyGen": [
"Q02383"
],
"iPTMnet": [
"Q02383"
],
"PhosphoSitePlus": [
"Q02383"
],
"BioMuta": [
"SEMG2"
],
"DMDM": [
"401079"
],
"jPOST": [
"Q02383"
],
"MassIVE": [
"Q02383"
],
"PaxDb": [
"9606-ENSP00000361855"
],
"PeptideAtlas": [
"Q02383"
],
"ProteomicsDB": [
"58084"
],
"Pumba": [
"Q02383"
],
"Antibodypedia": [
"27534"
],
"DNASU": [
"6407"
],
"Ensembl": [
"ENST00000372769.4"
],
"KEGG": [
"hsa:6407"
],
"MANE-Select": [
"ENST00000372769.4"
],
"UCSC": [
"uc002xnk.4"
],
"AGR": [
"HGNC:10743"
],
"CTD": [
"6407"
],
"DisGeNET": [
"6407"
],
"GeneCards": [
"SEMG2"
],
"HGNC": [
"HGNC:10743"
],
"HPA": [
"ENSG00000124157"
],
"MIM": [
"182141"
],
"neXtProt": [
"NX_Q02383"
],
"OpenTargets": [
"ENSG00000124157"
],
"PharmGKB": [
"PA35665"
],
"VEuPathDB": [
"HostDB:ENSG00000124157"
],
"eggNOG": [
"ENOG502T80H"
],
"GeneTree": [
"ENSGT00940000162560"
],
"HOGENOM": [
"CLU_034710_0_0_1"
],
"InParanoid": [
"Q02383"
],
"OMA": [
"HGKSQNQ"
],
"OrthoDB": [
"4729048at2759"
],
"PhylomeDB": [
"Q02383"
],
"TreeFam": [
"TF342360"
],
"PathwayCommons": [
"Q02383"
],
"SignaLink": [
"Q02383"
],
"BioGRID-ORCS": [
"6407"
],
"ChiTaRS": [
"SEMG2"
],
"GeneWiki": [
"SEMG2"
],
"GenomeRNAi": [
"6407"
],
"Pharos": [
"Q02383"
],
"PRO": [
"PR:Q02383"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"Q02383"
],
"Bgee": [
"ENSG00000124157"
],
"GO": [
"GO:0070062",
"GO:0005615",
"GO:0005634",
"GO:0002020",
"GO:0008270",
"GO:0019731",
"GO:0050817",
"GO:1901318",
"GO:1900005",
"GO:0048240"
],
"InterPro": [
"IPR008836"
],
"PANTHER": [
"PTHR10547:SF6",
"PTHR10547"
],
"Pfam": [
"PF05474"
]
},
"citations": [
{
"title": "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein.",
"pubmedID": "1584792",
"doi": "10.1073/pnas.89.10.4559"
},
{
"title": "Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20.",
"pubmedID": "1517240",
"doi": "10.1016/s0021-9258(19)37155-8"
},
{
"title": "Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.",
"pubmedID": "14629036",
"doi": "10.1007/s00239-003-2474-x"
},
{
"title": "The DNA sequence and comparative analysis of human chromosome 20.",
"pubmedID": "11780052",
"doi": "10.1038/414865a"
},
{
"title": "Isolation and structure determination of two peptides occurring in human seminal plasma.",
"pubmedID": "2757795"
},
{
"title": "Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II.",
"pubmedID": "8665951",
"doi": "10.1111/j.1432-1033.1996.0048q.x"
},
{
"title": "Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor.",
"pubmedID": "8665956",
"doi": "10.1111/j.1432-1033.1996.0088q.x"
}
],
"sequence": {
"length": 582,
"mass": 65444,
"checksum": "EBF63FBF3A8EC45B",
"modified": {
"$date": {
"$numberLong": "741484800000"
}
},
"version": 1,
"sequence": "MKSIILFVLSLLLILEKQAAVMGQKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST"
},
"existence": 0,
"relevance": 1,
"proteinID": 585165474
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}