Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 6753
{
"geneID": 6753,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"CP068256.2"
]
},
"genePos": {
"start": 37204237,
"end": 37220548
},
"orientation": false,
"symbol": "SSTR3",
"created": {
"$date": {
"$numberLong": "1738333349190"
}
},
"crossReference": {
"enseGeneID": "ENSG00000278195",
"enseRnaID": [
"ENST00000610913.2"
],
"enseProtID": [
"ENSP00000480971.1"
]
},
"chrom": {
"pos": "22",
"type": 1,
"loc": "22q13.1"
},
"desc": "somatostatin receptor 3",
"geneType": 5,
"mim": [
{
"id": 182453,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-1852241",
"term": "Organelle biogenesis and maintenance",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-5617833",
"term": "Cilium Assembly",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-5620920",
"term": "Cargo trafficking to the periciliary membrane",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418594",
"term": "G alpha (i) signalling events",
"cat": 13
},
{
"id": "R-HSA-5620922",
"term": "BBSome-mediated cargo-targeting to cilium",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0004930",
"term": "G protein-coupled receptor activity",
"cat": 0
},
{
"id": "GO:0004994",
"term": "somatostatin receptor activity",
"cat": 0
},
{
"id": "GO:0005102",
"term": "signaling receptor binding",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
19071123,
22651821,
32814053
],
"cat": 0
},
{
"id": "GO:0042923",
"term": "neuropeptide binding",
"cat": 0
},
{
"id": "GO:0007187",
"term": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
"cat": 1
},
{
"id": "GO:0007218",
"term": "neuropeptide signaling pathway",
"cat": 1
},
{
"id": "GO:0007267",
"term": "cell-cell signaling",
"pubMed": [
1337145
],
"cat": 1
},
{
"id": "GO:0007283",
"term": "spermatogenesis",
"cat": 1
},
{
"id": "GO:0008285",
"term": "negative regulation of cell population proliferation",
"cat": 1
},
{
"id": "GO:0008628",
"term": "hormone-mediated apoptotic signaling pathway",
"pubMed": [
8961277
],
"cat": 1
},
{
"id": "GO:0021549",
"term": "cerebellum development",
"cat": 1
},
{
"id": "GO:0030900",
"term": "forebrain development",
"cat": 1
},
{
"id": "GO:0038170",
"term": "somatostatin signaling pathway",
"cat": 1
},
{
"id": "GO:0042594",
"term": "response to starvation",
"cat": 1
},
{
"id": "GO:0071385",
"term": "cellular response to glucocorticoid stimulus",
"cat": 1
},
{
"id": "GO:0071392",
"term": "cellular response to estradiol stimulus",
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005929",
"term": "cilium",
"pubMed": [
28154160
],
"cat": 2
},
{
"id": "GO:0043005",
"term": "neuron projection",
"cat": 2
},
{
"id": "GO:0060170",
"term": "ciliary membrane",
"cat": 2
},
{
"id": "GO:0097730",
"term": "non-motile cilium",
"cat": 2
}
],
"protein": [
{
"symbol": "SSR3_HUMAN",
"name": "Somatostatin receptor type 3",
"accession": [
"P32745",
"A8K550",
"Q53ZR7"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"M96738",
"AY277678",
"AY322541",
"CR456585",
"AK291165",
"Z82188",
"BC096829"
],
"CCDS": [
"CCDS13944.1"
],
"PIR": [
"A46226"
],
"RefSeq": [
"NP_001042.1",
"NP_001265616.1",
"XP_005261778.1",
"XP_006724374.1",
"XP_011528651.1",
"XP_016884412.1",
"XP_016884413.1"
],
"AlphaFoldDB": [
"P32745"
],
"SMR": [
"P32745"
],
"BioGRID": [
"112631"
],
"CORUM": [
"P32745"
],
"IntAct": [
"P32745"
],
"MINT": [
"P32745"
],
"STRING": [
"9606.ENSP00000480971"
],
"BindingDB": [
"P32745"
],
"ChEMBL": [
"CHEMBL2028"
],
"DrugBank": [
"DB15494",
"DB13985",
"DB06663",
"DB09099"
],
"DrugCentral": [
"P32745"
],
"GuidetoPHARMACOLOGY": [
"357"
],
"TCDB": [
"9.A.14.13.23"
],
"GlyCosmos": [
"P32745"
],
"GlyGen": [
"P32745"
],
"iPTMnet": [
"P32745"
],
"PhosphoSitePlus": [
"P32745"
],
"BioMuta": [
"SSTR3"
],
"DMDM": [
"417815"
],
"MassIVE": [
"P32745"
],
"PaxDb": [
"9606-ENSP00000480971"
],
"PeptideAtlas": [
"P32745"
],
"ProteomicsDB": [
"54880"
],
"Antibodypedia": [
"74216"
],
"DNASU": [
"6753"
],
"Ensembl": [
"ENST00000610913.2",
"ENST00000617123.1"
],
"KEGG": [
"hsa:6753"
],
"MANE-Select": [
"ENST00000610913.2"
],
"UCSC": [
"uc021wos.3"
],
"AGR": [
"HGNC:11332"
],
"CTD": [
"6753"
],
"DisGeNET": [
"6753"
],
"GeneCards": [
"SSTR3"
],
"HGNC": [
"HGNC:11332"
],
"HPA": [
"ENSG00000278195"
],
"MIM": [
"182453"
],
"neXtProt": [
"NX_P32745"
],
"OpenTargets": [
"ENSG00000278195"
],
"PharmGKB": [
"PA36156"
],
"VEuPathDB": [
"HostDB:ENSG00000278195"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT00940000162038"
],
"HOGENOM": [
"CLU_009579_8_1_1"
],
"InParanoid": [
"P32745"
],
"OMA": [
"NTSSAWP"
],
"OrthoDB": [
"5393360at2759"
],
"PhylomeDB": [
"P32745"
],
"TreeFam": [
"TF315737"
],
"PathwayCommons": [
"P32745"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-418594",
"R-HSA-5620922"
],
"SignaLink": [
"P32745"
],
"SIGNOR": [
"P32745"
],
"BioGRID-ORCS": [
"6753"
],
"GeneWiki": [
"Somatostatin_receptor_3"
],
"GenomeRNAi": [
"6753"
],
"Pharos": [
"P32745"
],
"PRO": [
"PR:P32745"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P32745"
],
"Bgee": [
"ENSG00000278195"
],
"GO": [
"GO:0060170",
"GO:0005929",
"GO:0043005",
"GO:0097730",
"GO:0005886",
"GO:0004930",
"GO:0042923",
"GO:0005102",
"GO:0004994",
"GO:0007267",
"GO:0071392",
"GO:0071385",
"GO:0021549",
"GO:0030900",
"GO:0007187",
"GO:0008628",
"GO:0008285",
"GO:0007218",
"GO:0042594",
"GO:0007283"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000276",
"IPR017452",
"IPR000586",
"IPR001856"
],
"PANTHER": [
"PTHR24229",
"PTHR24229:SF42"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR00237",
"PR00246",
"PR00589"
],
"SMART": [
"SM01381"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase.",
"pubmedID": "1337145",
"doi": "10.1210/mend.6.12.1337145"
},
{
"title": "A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides.",
"pubmedID": "8097479",
"doi": "10.1016/0014-5793(93)80124-d"
},
{
"title": "A genome annotation-driven approach to cloning the human ORFeome.",
"pubmedID": "15461802",
"doi": "10.1186/gb-2004-5-10-r84"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "The DNA sequence of human chromosome 22.",
"pubmedID": "10591208",
"doi": "10.1038/990031"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
}
],
"sequence": {
"length": 418,
"mass": 45847,
"checksum": "1227095F801190C4",
"modified": {
"$date": {
"$numberLong": "749433600000"
}
},
"version": 1,
"sequence": "MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL"
},
"existence": 0,
"relevance": 1,
"proteinID": 2398521989
}
],
"mRNAExpressions": {
"proteinAtlas": [
{
"l": "T-cells",
"c": "naive CD4 T-cell",
"e": 1.1
}
]
},
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}