Details Currently Unavailable
A detailed, interactive page could not be generated for the requested gene. This usually happens when there is no significant expression data (CSI) available for it in our database.
AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 6754
{
"geneID": 6754,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049651.2"
]
},
"genePos": {
"start": 23035312,
"end": 23039237
},
"orientation": true,
"symbol": "SSTR4",
"created": {
"$date": {
"$numberLong": "1738333349190"
}
},
"crossReference": {
"enseGeneID": "ENSG00000132671",
"enseRnaID": [
"ENST00000255008.5"
],
"enseProtID": [
"ENSP00000255008.3"
]
},
"chrom": {
"pos": "20",
"type": 1,
"loc": "20p11.21"
},
"desc": "somatostatin receptor 4",
"geneType": 5,
"mim": [
{
"id": 182454,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418594",
"term": "G alpha (i) signalling events",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0004994",
"term": "somatostatin receptor activity",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
19426801
],
"cat": 0
},
{
"id": "GO:0042923",
"term": "neuropeptide binding",
"cat": 0
},
{
"id": "GO:0007186",
"term": "G protein-coupled receptor signaling pathway",
"pubMed": [
9892014
],
"cat": 1
},
{
"id": "GO:0007187",
"term": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
"cat": 1
},
{
"id": "GO:0007218",
"term": "neuropeptide signaling pathway",
"cat": 1
},
{
"id": "GO:0008285",
"term": "negative regulation of cell population proliferation",
"cat": 1
},
{
"id": "GO:0016477",
"term": "cell migration",
"cat": 1
},
{
"id": "GO:0030900",
"term": "forebrain development",
"cat": 1
},
{
"id": "GO:0038170",
"term": "somatostatin signaling pathway",
"cat": 1
},
{
"id": "GO:0070374",
"term": "positive regulation of ERK1 and ERK2 cascade",
"cat": 1
},
{
"id": "GO:0071385",
"term": "cellular response to glucocorticoid stimulus",
"cat": 1
},
{
"id": "GO:0090238",
"term": "positive regulation of arachidonate secretion",
"cat": 1
},
{
"id": "GO:0106072",
"term": "negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0043005",
"term": "neuron projection",
"cat": 2
}
],
"protein": [
{
"symbol": "SSR4_HUMAN",
"name": "Somatostatin receptor type 4",
"accession": [
"P31391",
"Q17RM1",
"Q17RM3",
"Q9UIY1"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"D16826",
"L14856",
"L07833",
"L07061",
"AY548169",
"AL049651",
"CH471133",
"BC069063",
"BC117270",
"BC117272"
],
"CCDS": [
"CCDS42856.1"
],
"PIR": [
"JN0605"
],
"RefSeq": [
"NP_001043.2"
],
"PDB": [
"7XMS",
"7XMT"
],
"PDBsum": [
"7XMS",
"7XMT"
],
"AlphaFoldDB": [
"P31391"
],
"EMDB": [
"EMD-33303",
"EMD-33304"
],
"SMR": [
"P31391"
],
"BioGRID": [
"112632"
],
"CORUM": [
"P31391"
],
"IntAct": [
"P31391"
],
"STRING": [
"9606.ENSP00000255008"
],
"BindingDB": [
"P31391"
],
"ChEMBL": [
"CHEMBL1853"
],
"DrugBank": [
"DB13985",
"DB09099"
],
"DrugCentral": [
"P31391"
],
"GuidetoPHARMACOLOGY": [
"358"
],
"GlyCosmos": [
"P31391"
],
"GlyGen": [
"P31391"
],
"iPTMnet": [
"P31391"
],
"PhosphoSitePlus": [
"P31391"
],
"BioMuta": [
"SSTR4"
],
"DMDM": [
"206729897"
],
"MassIVE": [
"P31391"
],
"PaxDb": [
"9606-ENSP00000255008"
],
"PeptideAtlas": [
"P31391"
],
"Antibodypedia": [
"20974"
],
"DNASU": [
"6754"
],
"Ensembl": [
"ENST00000255008.5"
],
"KEGG": [
"hsa:6754"
],
"MANE-Select": [
"ENST00000255008.5"
],
"UCSC": [
"uc002wsr.3"
],
"AGR": [
"HGNC:11333"
],
"CTD": [
"6754"
],
"DisGeNET": [
"6754"
],
"GeneCards": [
"SSTR4"
],
"HGNC": [
"HGNC:11333"
],
"HPA": [
"ENSG00000132671"
],
"MIM": [
"182454"
],
"neXtProt": [
"NX_P31391"
],
"OpenTargets": [
"ENSG00000132671"
],
"PharmGKB": [
"PA36157"
],
"VEuPathDB": [
"HostDB:ENSG00000132671"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT00940000156819"
],
"HOGENOM": [
"CLU_009579_8_1_1"
],
"InParanoid": [
"P31391"
],
"OMA": [
"AIQCIYA"
],
"OrthoDB": [
"5393360at2759"
],
"PhylomeDB": [
"P31391"
],
"TreeFam": [
"TF315737"
],
"PathwayCommons": [
"P31391"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-418594"
],
"SignaLink": [
"P31391"
],
"SIGNOR": [
"P31391"
],
"BioGRID-ORCS": [
"6754"
],
"GeneWiki": [
"Somatostatin_receptor_4"
],
"GenomeRNAi": [
"6754"
],
"Pharos": [
"P31391"
],
"PRO": [
"PR:P31391"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P31391"
],
"Bgee": [
"ENSG00000132671"
],
"GO": [
"GO:0043005",
"GO:0005886",
"GO:0042923",
"GO:0004994",
"GO:0016477",
"GO:0071385",
"GO:0030900",
"GO:0007186",
"GO:0007187",
"GO:0106072",
"GO:0008285",
"GO:0007218",
"GO:0090238",
"GO:0070374"
],
"CDD": [
"cd15973"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000276",
"IPR017452",
"IPR000586",
"IPR001512"
],
"PANTHER": [
"PTHR24229",
"PTHR24229:SF35"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR00237",
"PR00246",
"PR00590"
],
"SMART": [
"SM01381"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.",
"pubmedID": "8512564",
"doi": "10.1006/bbrc.1993.1673"
},
{
"title": "Cloning and characterization of a fourth human somatostatin receptor.",
"pubmedID": "8483934",
"doi": "10.1073/pnas.90.9.4196"
},
{
"title": "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.",
"pubmedID": "8373420",
"doi": "10.1006/bbrc.1993.2122"
},
{
"title": "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.",
"pubmedID": "8100352"
},
{
"title": "The DNA sequence and comparative analysis of human chromosome 20.",
"pubmedID": "11780052",
"doi": "10.1038/414865a"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
}
],
"sequence": {
"length": 388,
"mass": 42003,
"checksum": "DFCD9393620EDFC9",
"modified": {
"$date": {
"$numberLong": "1222128000000"
}
},
"version": 2,
"sequence": "MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF"
},
"existence": 0,
"relevance": 1,
"proteinID": 4268537829
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}