Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 7015
{
"geneID": 7015,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AB016767.1"
]
},
"genePos": {
"start": 5001,
"end": 46881
},
"orientation": true,
"symbol": "TERT",
"created": {
"$date": {
"$numberLong": "1738333349210"
}
},
"crossReference": {
"enseGeneID": "ENSG00000164362",
"enseRnaID": [
"ENST00000334602.10"
],
"enseProtID": [
"ENSP00000334346.6"
]
},
"chrom": {
"pos": "5",
"type": 1,
"loc": "5p15.33"
},
"desc": "telomerase reverse transcriptase",
"geneType": 5,
"mim": [
{
"id": 187270,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-1266738",
"term": "Developmental Biology",
"cat": 10
},
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-1640170",
"term": "Cell Cycle",
"cat": 10
},
{
"id": "R-HSA-195721",
"term": "Signaling by WNT",
"cat": 11
},
{
"id": "R-HSA-73886",
"term": "Chromosome Maintenance",
"cat": 11
},
{
"id": "R-HSA-9730414",
"term": "MITF-M-regulated melanocyte development",
"cat": 11
},
{
"id": "R-HSA-157579",
"term": "Telomere Maintenance",
"cat": 12
},
{
"id": "R-HSA-201681",
"term": "TCF dependent signaling in response to WNT",
"cat": 12
},
{
"id": "R-HSA-9856651",
"term": "MITF-M-dependent gene expression",
"cat": 12
},
{
"id": "R-HSA-180786",
"term": "Extension of Telomeres",
"cat": 13
},
{
"id": "R-HSA-201722",
"term": "Formation of the beta-catenin:TCF transactivating complex",
"cat": 13
},
{
"id": "R-HSA-9825895",
"term": "Regulation of MITF-M-dependent genes involved in DNA damage repair and senescence",
"cat": 13
},
{
"id": "R-HSA-171319",
"term": "Telomere Extension By Telomerase",
"cat": 14
},
{
"id": "GO:0000049",
"term": "tRNA binding",
"pubMed": [
21937513
],
"cat": 0
},
{
"id": "GO:0001223",
"term": "transcription coactivator binding",
"pubMed": [
19571879
],
"cat": 0
},
{
"id": "GO:0003677",
"term": "DNA binding",
"pubMed": [
21937513
],
"cat": 0
},
{
"id": "GO:0003720",
"term": "telomerase activity",
"cat": 0
},
{
"id": "GO:0003720",
"term": "telomerase activity",
"pubMed": [
9398860,
9443919,
12135483,
16043710,
16507993,
17940095,
18082603,
21531765,
29695869
],
"cat": 0
},
{
"id": "GO:0003720",
"term": "telomerase activity",
"pubMed": [
11927518,
14991929,
23474713,
23784080
],
"cat": 0
},
{
"id": "GO:0003723",
"term": "RNA binding",
"pubMed": [
16507993,
17940095,
18082603,
19701182,
20351177
],
"cat": 0
},
{
"id": "GO:0003964",
"term": "RNA-directed DNA polymerase activity",
"pubMed": [
21937513
],
"cat": 0
},
{
"id": "GO:0003964",
"term": "RNA-directed DNA polymerase activity",
"pubMed": [
25569094
],
"cat": 0
},
{
"id": "GO:0003968",
"term": "RNA-dependent RNA polymerase activity",
"pubMed": [
19701182
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
11701125,
12377759,
12699629,
15044100,
15381700,
17237767,
17940095,
18082603,
18358808,
19179534,
19487455,
19567472,
19571879,
19843693,
21119197,
21829167,
21846770,
22011238,
22226966,
24550003,
25172512,
25589350,
28255170
],
"cat": 0
},
{
"id": "GO:0042162",
"term": "telomeric DNA binding",
"cat": 0
},
{
"id": "GO:0042802",
"term": "identical protein binding",
"pubMed": [
23474713
],
"cat": 0
},
{
"id": "GO:0042803",
"term": "protein homodimerization activity",
"pubMed": [
11432839
],
"cat": 0
},
{
"id": "GO:0042803",
"term": "protein homodimerization activity",
"pubMed": [
23474713
],
"cat": 0
},
{
"id": "GO:0046872",
"term": "metal ion binding",
"cat": 0
},
{
"id": "GO:0051087",
"term": "protein-folding chaperone binding",
"pubMed": [
10197982,
19751963
],
"cat": 0
},
{
"id": "GO:0070034",
"term": "telomerase RNA binding",
"cat": 0
},
{
"id": "GO:0070034",
"term": "telomerase RNA binding",
"pubMed": [
11432839
],
"cat": 0
},
{
"id": "GO:0070034",
"term": "telomerase RNA binding",
"pubMed": [
16507993,
17940095,
18082603,
19701182,
20351177
],
"cat": 0
},
{
"id": "GO:0098680",
"term": "template-free RNA nucleotidyltransferase",
"pubMed": [
19701182
],
"cat": 0
},
{
"id": "GO:0000723",
"term": "telomere maintenance",
"pubMed": [
12135483
],
"cat": 1
},
{
"id": "GO:0001172",
"term": "RNA-templated transcription",
"pubMed": [
19701182
],
"cat": 1
},
{
"id": "GO:0006278",
"term": "RNA-templated DNA biosynthetic process",
"pubMed": [
9398860
],
"cat": 1
},
{
"id": "GO:0007004",
"term": "telomere maintenance via telomerase",
"cat": 1
},
{
"id": "GO:0007004",
"term": "telomere maintenance via telomerase",
"pubMed": [
9443919,
16043710,
17940095,
19701182,
21531765,
29695869
],
"cat": 1
},
{
"id": "GO:0007004",
"term": "telomere maintenance via telomerase",
"pubMed": [
9454332
],
"cat": 1
},
{
"id": "GO:0007004",
"term": "telomere maintenance via telomerase",
"pubMed": [
2805070,
20351177
],
"cat": 1
},
{
"id": "GO:0007005",
"term": "mitochondrion organization",
"pubMed": [
21937513
],
"cat": 1
},
{
"id": "GO:0010629",
"term": "negative regulation of gene expression",
"pubMed": [
11927518
],
"cat": 1
},
{
"id": "GO:0022616",
"term": "DNA strand elongation",
"pubMed": [
16043710
],
"cat": 1
},
{
"id": "GO:0030177",
"term": "positive regulation of Wnt signaling pathway",
"pubMed": [
19571879
],
"cat": 1
},
{
"id": "GO:0030422",
"term": "siRNA processing",
"pubMed": [
19701182
],
"cat": 1
},
{
"id": "GO:0031647",
"term": "regulation of protein stability",
"pubMed": [
24415760,
26194824
],
"cat": 1
},
{
"id": "GO:0031647",
"term": "regulation of protein stability",
"pubMed": [
26194824
],
"cat": 1
},
{
"id": "GO:0032092",
"term": "positive regulation of protein binding",
"pubMed": [
24415760
],
"cat": 1
},
{
"id": "GO:0042635",
"term": "positive regulation of hair cycle",
"cat": 1
},
{
"id": "GO:0043524",
"term": "negative regulation of neuron apoptotic process",
"cat": 1
},
{
"id": "GO:0045766",
"term": "positive regulation of angiogenesis",
"cat": 1
},
{
"id": "GO:0046326",
"term": "positive regulation of D-glucose import",
"cat": 1
},
{
"id": "GO:0046686",
"term": "response to cadmium ion",
"cat": 1
},
{
"id": "GO:0051000",
"term": "positive regulation of nitric-oxide synthase activity",
"pubMed": [
11927518
],
"cat": 1
},
{
"id": "GO:0070200",
"term": "establishment of protein localization to telomere",
"pubMed": [
25589350
],
"cat": 1
},
{
"id": "GO:0071456",
"term": "cellular response to hypoxia",
"pubMed": [
11313459
],
"cat": 1
},
{
"id": "GO:0071897",
"term": "DNA biosynthetic process",
"pubMed": [
9398860
],
"cat": 1
},
{
"id": "GO:0090399",
"term": "replicative senescence",
"pubMed": [
9454332
],
"cat": 1
},
{
"id": "GO:0140745",
"term": "siRNA transcription",
"pubMed": [
19701182
],
"cat": 1
},
{
"id": "GO:1900087",
"term": "positive regulation of G1/S transition of mitotic cell cycle",
"cat": 1
},
{
"id": "GO:1902895",
"term": "positive regulation of miRNA transcription",
"pubMed": [
25569094
],
"cat": 1
},
{
"id": "GO:1903620",
"term": "positive regulation of transdifferentiation",
"cat": 1
},
{
"id": "GO:1904707",
"term": "positive regulation of vascular associated smooth muscle cell proliferation",
"cat": 1
},
{
"id": "GO:1904751",
"term": "positive regulation of protein localization to nucleolus",
"pubMed": [
24415760
],
"cat": 1
},
{
"id": "GO:1904754",
"term": "positive regulation of vascular associated smooth muscle cell migration",
"cat": 1
},
{
"id": "GO:2000352",
"term": "negative regulation of endothelial cell apoptotic process",
"cat": 1
},
{
"id": "GO:2000648",
"term": "positive regulation of stem cell proliferation",
"cat": 1
},
{
"id": "GO:2000773",
"term": "negative regulation of cellular senescence",
"pubMed": [
11927518
],
"cat": 1
},
{
"id": "GO:2000773",
"term": "negative regulation of cellular senescence",
"pubMed": [
11313459
],
"cat": 1
},
{
"id": "GO:2001240",
"term": "negative regulation of extrinsic apoptotic signaling pathway in absence of ligand",
"pubMed": [
10449030
],
"cat": 1
},
{
"id": "GO:0000333",
"term": "telomerase catalytic core complex",
"cat": 2
},
{
"id": "GO:0000333",
"term": "telomerase catalytic core complex",
"pubMed": [
9398860,
9443919,
16507993,
17940095,
18082603
],
"cat": 2
},
{
"id": "GO:0000333",
"term": "telomerase catalytic core complex",
"pubMed": [
11313459
],
"cat": 2
},
{
"id": "GO:0000333",
"term": "telomerase catalytic core complex",
"pubMed": [
19701182
],
"cat": 2
},
{
"id": "GO:0000781",
"term": "chromosome, telomeric region",
"pubMed": [
12135483
],
"cat": 2
},
{
"id": "GO:0000781",
"term": "chromosome, telomeric region",
"pubMed": [
25589350
],
"cat": 2
},
{
"id": "GO:0000783",
"term": "nuclear telomere cap complex",
"pubMed": [
15632080
],
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
21829167,
24415760
],
"cat": 2
},
{
"id": "GO:0005654",
"term": "nucleoplasm",
"pubMed": [
19567472
],
"cat": 2
},
{
"id": "GO:0005654",
"term": "nucleoplasm",
"cat": 2
},
{
"id": "GO:0005697",
"term": "telomerase holoenzyme complex",
"pubMed": [
12135483,
18082603,
29695869
],
"cat": 2
},
{
"id": "GO:0005697",
"term": "telomerase holoenzyme complex",
"pubMed": [
19701182
],
"cat": 2
},
{
"id": "GO:0005697",
"term": "telomerase holoenzyme complex",
"pubMed": [
20351177
],
"cat": 2
},
{
"id": "GO:0005697",
"term": "telomerase holoenzyme complex",
"pubMed": [
10757788,
22527283
],
"cat": 2
},
{
"id": "GO:0005730",
"term": "nucleolus",
"pubMed": [
22226966
],
"cat": 2
},
{
"id": "GO:0005730",
"term": "nucleolus",
"pubMed": [
26194824
],
"cat": 2
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0016605",
"term": "PML body",
"pubMed": [
19567472
],
"cat": 2
},
{
"id": "GO:0016607",
"term": "nuclear speck",
"cat": 2
},
{
"id": "GO:0031379",
"term": "RNA-directed RNA polymerase complex",
"pubMed": [
19701182
],
"cat": 2
},
{
"id": "GO:0042645",
"term": "mitochondrial nucleoid",
"pubMed": [
21937513
],
"cat": 2
},
{
"id": "GO:1990572",
"term": "TERT-RMRP complex",
"pubMed": [
19701182
],
"cat": 2
}
],
"protein": [
{
"symbol": "TERT_HUMAN",
"name": "Telomerase reverse transcriptase",
"accession": [
"O14746",
"O14783",
"Q2XS35",
"Q8N6C3",
"Q8NG38",
"Q8NG46"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"Rhea": [
"RHEA:22508",
"RHEA-COMP:17339",
"RHEA-COMP:17340"
],
"ChEBI": [
"CHEBI:33019",
"CHEBI:61560",
"CHEBI:173112",
"CHEBI:18420",
"CHEBI:18420",
"CHEBI:18420"
],
"EC": [
"2.7.7.49"
],
"MIM": [
"609135",
"613989",
"614742",
"613989",
"615134",
"187270",
"609135",
"613989",
"614742",
"615134"
],
"EMBL": [
"AF018167",
"AF015950",
"AF128894",
"AF128893",
"AB085628",
"AB086379",
"AB086950",
"AY007685",
"DQ264729",
"AC114291",
"CH471102"
],
"CCDS": [
"CCDS3861.2",
"CCDS54831.1"
],
"PIR": [
"T03844"
],
"RefSeq": [
"NP_001180305.1",
"NP_937983.2"
],
"PDB": [
"2BCK",
"4B18",
"4MNQ",
"5MEN",
"5MEO",
"5MEP",
"5MEQ",
"5MER",
"5UGW",
"7BG9",
"7QXA",
"7QXB",
"7QXS",
"7TRD",
"7TRE",
"7TRF",
"7V99"
],
"PDBsum": [
"2BCK",
"4B18",
"4MNQ",
"5MEN",
"5MEO",
"5MEP",
"5MEQ",
"5MER",
"5UGW",
"7BG9",
"7QXA",
"7QXB",
"7QXS",
"7TRD",
"7TRE",
"7TRF",
"7V99"
],
"AlphaFoldDB": [
"O14746"
],
"EMDB": [
"EMD-12174",
"EMD-14196",
"EMD-14197",
"EMD-14198",
"EMD-14199",
"EMD-2310",
"EMD-2311",
"EMD-2312",
"EMD-26086",
"EMD-26087",
"EMD-26088",
"EMD-31811",
"EMD-31812"
],
"SMR": [
"O14746"
],
"BioGRID": [
"112874"
],
"ComplexPortal": [
"CPX-17",
"CPX-20",
"CPX-265"
],
"CORUM": [
"O14746"
],
"DIP": [
"DIP-40646N"
],
"ELM": [
"O14746"
],
"IntAct": [
"O14746"
],
"MINT": [
"O14746"
],
"STRING": [
"9606.ENSP00000309572"
],
"BindingDB": [
"O14746"
],
"ChEMBL": [
"CHEMBL2916"
],
"DrugBank": [
"DB05036",
"DB12747",
"DB00495"
],
"DrugCentral": [
"O14746"
],
"GlyGen": [
"O14746"
],
"iPTMnet": [
"O14746"
],
"PhosphoSitePlus": [
"O14746"
],
"BioMuta": [
"TERT"
],
"MassIVE": [
"O14746"
],
"PaxDb": [
"9606-ENSP00000309572"
],
"PeptideAtlas": [
"O14746"
],
"ProteomicsDB": [
"48203",
"48204",
"48205",
"73418"
],
"ABCD": [
"O14746"
],
"Antibodypedia": [
"8998"
],
"DNASU": [
"7015"
],
"Ensembl": [
"ENST00000310581.10",
"ENST00000334602.10",
"ENST00000460137.6"
],
"KEGG": [
"hsa:7015"
],
"MANE-Select": [
"ENST00000310581.10"
],
"UCSC": [
"uc003jcb.2"
],
"AGR": [
"HGNC:11730"
],
"CTD": [
"7015"
],
"DisGeNET": [
"7015"
],
"GeneCards": [
"TERT"
],
"GeneReviews": [
"TERT"
],
"HGNC": [
"HGNC:11730"
],
"HPA": [
"ENSG00000164362"
],
"MalaCards": [
"TERT"
],
"neXtProt": [
"NX_O14746"
],
"OpenTargets": [
"ENSG00000164362"
],
"Orphanet": [
"1501",
"457246",
"146",
"1775",
"618",
"3322",
"88",
"2032",
"2495"
],
"PharmGKB": [
"PA36447"
],
"VEuPathDB": [
"HostDB:ENSG00000164362"
],
"eggNOG": [
"KOG1005"
],
"GeneTree": [
"ENSGT00390000018531"
],
"HOGENOM": [
"CLU_001996_2_0_1"
],
"InParanoid": [
"O14746"
],
"OMA": [
"LAAMKFH"
],
"OrthoDB": [
"55913at2759"
],
"PhylomeDB": [
"O14746"
],
"TreeFam": [
"TF329048"
],
"PathwayCommons": [
"O14746"
],
"Reactome": [
"R-HSA-171319",
"R-HSA-201722",
"R-HSA-9825895"
],
"SignaLink": [
"O14746"
],
"SIGNOR": [
"O14746"
],
"BioGRID-ORCS": [
"7015"
],
"EvolutionaryTrace": [
"O14746"
],
"GeneWiki": [
"Telomerase_reverse_transcriptase"
],
"GenomeRNAi": [
"7015"
],
"Pharos": [
"O14746"
],
"PRO": [
"PR:O14746"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O14746"
],
"Bgee": [
"ENSG00000164362"
],
"ExpressionAtlas": [
"O14746"
],
"GO": [
"GO:0000781",
"GO:0005829",
"GO:0042645",
"GO:0016607",
"GO:0000783",
"GO:0005730",
"GO:0005654",
"GO:0005634",
"GO:0005886",
"GO:0016605",
"GO:0031379",
"GO:0000333",
"GO:0005697",
"GO:1990572",
"GO:0003677",
"GO:0042802",
"GO:0046872",
"GO:0042803",
"GO:0051087",
"GO:0003723",
"GO:0003968",
"GO:0003964",
"GO:0003720",
"GO:0070034",
"GO:0003721",
"GO:0042162",
"GO:0098680",
"GO:0001223",
"GO:0000049",
"GO:0071456",
"GO:0071897",
"GO:0022616",
"GO:0070200",
"GO:0007005",
"GO:2000773",
"GO:2000352",
"GO:2001240",
"GO:0010629",
"GO:0043524",
"GO:0045766",
"GO:1900087",
"GO:0046326",
"GO:0042635",
"GO:1902895",
"GO:0051000",
"GO:0032092",
"GO:1904751",
"GO:2000648",
"GO:1903620",
"GO:1904754",
"GO:1904707",
"GO:0030177",
"GO:0031647",
"GO:0090399",
"GO:0046686",
"GO:0006278",
"GO:0001172",
"GO:0030422",
"GO:0140745",
"GO:0000723",
"GO:0007004"
],
"CDD": [
"cd01648"
],
"Gene3D": [
"1.10.132.70",
"1.10.357.90",
"3.30.70.2630"
],
"IDEAL": [
"IID00690"
],
"InterPro": [
"IPR043502",
"IPR000477",
"IPR021891",
"IPR003545",
"IPR049139"
],
"PANTHER": [
"PTHR12066",
"PTHR12066:SF0"
],
"Pfam": [
"PF00078",
"PF12009",
"PF21399"
],
"PRINTS": [
"PR01365"
],
"SMART": [
"SM00975"
],
"SUPFAM": [
"SSF56672"
],
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"title": "hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.",
"pubmedID": "9288757",
"doi": "10.1016/s0092-8674(00)80538-3"
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"title": "Telomerase catalytic subunit homologs from fission yeast and human.",
"pubmedID": "9252327",
"doi": "10.1126/science.277.5328.955"
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"title": "Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT).",
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"doi": "10.1016/s0378-1119(99)00108-0"
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"title": "Expression profile of a gamma-deletion variant of the human telomerase reverse transcriptase gene.",
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"title": "Differential alternative splicing expressions of telomerase reverse transcriptase in gastrointestinal cell lines.",
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"title": "The DNA sequence and comparative analysis of human chromosome 5.",
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"title": "Regulated expression of telomerase activity in human T lymphocyte development and activation.",
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"title": "Human telomerase contains evolutionarily conserved catalytic and structural subunits.",
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"doi": "10.1101/gad.11.23.3109"
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"title": "Reconstitution of human telomerase activity in vitro.",
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"doi": "10.1016/s0960-9822(98)70067-3"
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"title": "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding.",
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"doi": "10.1091/mbc.11.10.3329"
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"title": "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase.",
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"title": "Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.",
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"doi": "10.1128/mcb.23.13.4598-4610.2003"
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"title": "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length.",
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"doi": "10.1016/j.bbrc.2004.02.166"
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"title": "Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells.",
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"doi": "10.1161/01.res.0000121104.05977.f3"
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"title": "Immunohistochemical localization of hTERT protein in human tissues.",
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"title": "Nucleolin interacts with telomerase.",
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"title": "Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer.",
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"doi": "10.1128/mcb.24.9.3720-3733.2004"
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"title": "Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT.",
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"title": "An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization.",
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"title": "Telomerase with mutated catalytic motifs has dominant negative effects on telomerase activity and inhibits cell growth.",
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"title": "The loss of telomerase activity in highly differentiated CD8+CD28-CD27- T cells is associated with decreased Akt (Ser473) phosphorylation.",
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"doi": "10.4049/jimmunol.178.12.7710"
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"title": "Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation.",
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"title": "Characterization of physical and functional anchor site interactions in human telomerase.",
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"title": "The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity.",
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"doi": "10.1093/nar/gkm002"
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"title": "Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.",
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"doi": "10.1074/jbc.m805138200"
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"title": "Ionizing radiation up-regulates telomerase activity in cancer cell lines by post-translational mechanism via ras/phosphatidylinositol 3-kinase/Akt pathway.",
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"title": "PML-IV functions as a negative regulator of telomerase by interacting with TERT.",
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"title": "Telomerase modulates Wnt signalling by association with target gene chromatin.",
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"doi": "10.1038/nature08137"
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"title": "Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo.",
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"doi": "10.1371/journal.pone.0007176"
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"title": "A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.",
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"doi": "10.1126/science.1165357"
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"title": "Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo.",
"pubmedID": "20351177",
"doi": "10.1128/mcb.00151-10"
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"title": "The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme.",
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"doi": "10.1093/nar/gkr630"
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"title": "The AAA-ATPase NVL2 is a telomerase component essential for holoenzyme assembly.",
"pubmedID": "22226966",
"doi": "10.1016/j.bbrc.2011.12.101"
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"title": "Nuclear import of hTERT requires a bipartite nuclear localization signal and Akt-mediated phosphorylation.",
"pubmedID": "22366458",
"doi": "10.1242/jcs.099267"
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"title": "Dyrk2-associated EDD-DDB1-VprBP E3 ligase inhibits telomerase by TERT degradation.",
"pubmedID": "23362280",
"doi": "10.1074/jbc.m112.416792"
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"title": "HIV-1 Vpr protein inhibits telomerase activity via the EDD-DDB1-VPRBP E3 ligase complex.",
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"doi": "10.1074/jbc.m112.416735"
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"title": "TERT promoter mutations in familial and sporadic melanoma.",
"pubmedID": "23348503",
"doi": "10.1126/science.1230062"
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"title": "ATF7 mediates TNF-alpha-induced telomere shortening.",
"pubmedID": "29490055",
"doi": "10.1093/nar/gky155"
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"title": "Crystal structure of HLA-A*2402 complexed with a telomerase peptide.",
"pubmedID": "16323248",
"doi": "10.1002/eji.200535424"
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"title": "Cryo-EM structure of substrate-bound human telomerase holoenzyme.",
"pubmedID": "29695869",
"doi": "10.1038/s41586-018-0062-x"
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"title": "Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure.",
"pubmedID": "15885610",
"doi": "10.1016/j.bcmd.2004.12.008"
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"title": "Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.",
"pubmedID": "15814878",
"doi": "10.1056/nejmoa042980"
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"title": "Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.",
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"doi": "10.1073/pnas.0508124102"
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"title": "Coronary artery disease and a functional polymorphism of hTERT.",
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"doi": "10.1016/j.bbrc.2006.07.103"
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"title": "Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation.",
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"doi": "10.1182/blood-2005-07-2622"
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"title": "Mutations in telomerase catalytic protein in Japanese children with aplastic anemia.",
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"title": "Functional characterization of natural telomerase mutations found in patients with hematologic disorders.",
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"title": "Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome.",
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"title": "Telomerase mutations in families with idiopathic pulmonary fibrosis.",
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"doi": "10.1056/nejmoa066157"
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"title": "Adult-onset pulmonary fibrosis caused by mutations in telomerase.",
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"title": "Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene.",
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"doi": "10.1182/blood-2007-10-120907"
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"title": "Defining the pathogenic role of telomerase mutations in myelodysplastic syndrome and acute myeloid leukemia.",
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"title": "Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia.",
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"title": "Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase.",
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"title": "Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells.",
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"doi": "10.1038/nature10084"
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"title": "Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis.",
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"title": "Pulmonary fibrosis, bone marrow failure, and telomerase mutation.",
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"title": "FARSA mutations mimic phenylalanyl-tRNA synthetase deficiency caused by FARSB defects.",
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"singleCellExpressions": {
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