Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 7179
{
"geneID": 7179,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC244111.3"
]
},
"genePos": {
"start": 5002,
"end": 89135
},
"orientation": false,
"symbol": "TPTE",
"created": {
"$date": {
"$numberLong": "1738333349239"
}
},
"crossReference": {
"enseGeneID": "ENSG00000274391",
"enseRnaID": [
"ENST00000612746.1"
],
"enseProtID": [
"ENSP00000483087.1"
]
},
"chrom": {
"pos": "21",
"type": 1,
"loc": "21p11.2"
},
"desc": "transmembrane phosphatase with tensin homology",
"geneType": 5,
"ontology": [
{
"id": "R-HSA-1430728",
"term": "Metabolism",
"cat": 10
},
{
"id": "R-HSA-556833",
"term": "Metabolism of lipids",
"cat": 11
},
{
"id": "R-HSA-1483257",
"term": "Phospholipid metabolism",
"cat": 12
},
{
"id": "R-HSA-1483255",
"term": "PI Metabolism",
"cat": 13
},
{
"id": "R-HSA-1660514",
"term": "Synthesis of PIPs at the Golgi membrane",
"cat": 14
},
{
"id": "GO:0004725",
"term": "protein tyrosine phosphatase activity",
"cat": 0
},
{
"id": "GO:0005216",
"term": "monoatomic ion channel activity",
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
32296183
],
"cat": 0
},
{
"id": "GO:0016314",
"term": "phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity",
"cat": 0
},
{
"id": "GO:0006470",
"term": "protein dephosphorylation",
"pubMed": [
10598804
],
"cat": 1
},
{
"id": "GO:0007165",
"term": "signal transduction",
"pubMed": [
10598804
],
"cat": 1
},
{
"id": "GO:0034220",
"term": "monoatomic ion transmembrane transport",
"cat": 1
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
},
{
"id": "GO:0016020",
"term": "membrane",
"cat": 2
}
],
"geneRelations": [
{
"type": 1,
"similarGenes": [
"85319"
]
}
],
"protein": [
{
"symbol": "TPTE_HUMAN",
"name": "Putative tyrosine-protein phosphatase TPTE",
"accession": [
"P56180",
"B2RAP7",
"C9J6D6",
"C9JKK8",
"Q6XPS4",
"Q6XPS5",
"Q71JA8",
"Q8NCS8"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"Rhea": [
"RHEA:10684",
"RHEA-COMP:10136",
"RHEA-COMP:10137"
],
"ChEBI": [
"CHEBI:15377",
"CHEBI:43474",
"CHEBI:46858",
"CHEBI:82620"
],
"EC": [
"3.1.3.48",
"3.1.3.48"
],
"EMBL": [
"AF007118",
"AY219886",
"AY219887",
"AY219888",
"AF495908",
"AK314285",
"AF254982",
"AF254983",
"AL078471",
"AL163201",
"BC028719"
],
"CCDS": [
"CCDS74771.1",
"CCDS74772.1",
"CCDS74773.1",
"CCDS77617.1"
],
"RefSeq": [
"NP_001277153.1",
"NP_954868.1",
"NP_954869.1",
"NP_954870.2"
],
"AlphaFoldDB": [
"P56180"
],
"SMR": [
"P56180"
],
"BioGRID": [
"113031"
],
"IntAct": [
"P56180"
],
"MINT": [
"P56180"
],
"STRING": [
"9606.ENSP00000484403"
],
"DEPOD": [
"TPTE"
],
"iPTMnet": [
"P56180"
],
"PhosphoSitePlus": [
"P56180"
],
"BioMuta": [
"TPTE"
],
"DMDM": [
"313104272"
],
"jPOST": [
"P56180"
],
"MassIVE": [
"P56180"
],
"PaxDb": [
"9606-ENSP00000484403"
],
"PeptideAtlas": [
"P56180"
],
"ProteomicsDB": [
"56895",
"56896",
"56897",
"56898"
],
"Antibodypedia": [
"73437"
],
"DNASU": [
"7179"
],
"Ensembl": [
"ENST00000427445.6",
"ENST00000612746.1",
"ENST00000618007.5",
"ENST00000622113.4"
],
"KEGG": [
"hsa:7179"
],
"MANE-Select": [
"ENST00000618007.5"
],
"UCSC": [
"uc002yip.2"
],
"AGR": [
"HGNC:12023"
],
"CTD": [
"7179"
],
"DisGeNET": [
"7179"
],
"GeneCards": [
"TPTE"
],
"HGNC": [
"HGNC:12023"
],
"HPA": [
"ENSG00000274391"
],
"MIM": [
"604336"
],
"neXtProt": [
"NX_P56180"
],
"OpenTargets": [
"ENSG00000274391"
],
"PharmGKB": [
"PA36702"
],
"VEuPathDB": [
"HostDB:ENSG00000274391"
],
"eggNOG": [
"KOG2283"
],
"GeneTree": [
"ENSGT00940000154335"
],
"HOGENOM": [
"CLU_020105_3_0_1"
],
"InParanoid": [
"P56180"
],
"OMA": [
"CPKFAND"
],
"OrthoDB": [
"5477362at2759"
],
"PhylomeDB": [
"P56180"
],
"TreeFam": [
"TF354329"
],
"PathwayCommons": [
"P56180"
],
"Reactome": [
"R-HSA-1660514"
],
"SignaLink": [
"P56180"
],
"BioGRID-ORCS": [
"7179"
],
"ChiTaRS": [
"TPTE"
],
"GeneWiki": [
"TPTE"
],
"GenomeRNAi": [
"7179"
],
"Pharos": [
"P56180"
],
"PRO": [
"PR:P56180"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P56180"
],
"Bgee": [
"ENSG00000274391"
],
"ExpressionAtlas": [
"P56180"
],
"GO": [
"GO:0005829",
"GO:0016020",
"GO:0005216",
"GO:0016314",
"GO:0004725",
"GO:0006470",
"GO:0007165"
],
"CDD": [
"cd14510"
],
"Gene3D": [
"2.60.40.1110",
"3.90.190.10",
"1.20.120.350"
],
"InterPro": [
"IPR035892",
"IPR051281",
"IPR005821",
"IPR029021",
"IPR045102",
"IPR014020",
"IPR029023",
"IPR016130",
"IPR000387",
"IPR027359"
],
"PANTHER": [
"PTHR12305",
"PTHR12305:SF60"
],
"Pfam": [
"PF00520",
"PF10409",
"PF22785"
],
"SMART": [
"SM01326"
],
"SUPFAM": [
"SSF52799",
"SSF49562",
"SSF81324"
],
"PROSITE": [
"PS51182",
"PS51181"
]
},
"citations": [
{
"title": "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.",
"pubmedID": "10598804",
"doi": "10.1007/s004390051122"
},
{
"title": "The TPTE gene family: cellular expression, subcellular localization and alternative splicing.",
"pubmedID": "14659893",
"doi": "10.1016/j.gene.2003.09.038"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "The DNA sequence of human chromosome 21.",
"pubmedID": "10830953",
"doi": "10.1038/35012518"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "The consensus coding sequences of human breast and colorectal cancers.",
"pubmedID": "16959974",
"doi": "10.1126/science.1133427"
}
],
"sequence": {
"length": 551,
"mass": 64322,
"checksum": "48C2F28BEAA0DDA6",
"modified": {
"$date": {
"$numberLong": "1291075200000"
}
},
"version": 3,
"sequence": "MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSPISESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVKTPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD"
},
"existence": 0,
"relevance": 1,
"proteinID": 497295660
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}