Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 7517
{
"geneID": 7517,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AL049840.8"
]
},
"genePos": {
"start": 103697617,
"end": 103715451
},
"orientation": true,
"symbol": "XRCC3",
"created": {
"$date": {
"$numberLong": "1738333349260"
}
},
"crossReference": {
"enseGeneID": "ENSG00000126215",
"enseRnaID": [
"ENST00000352127.11"
],
"enseProtID": [
"ENSP00000343392.7"
]
},
"chrom": {
"pos": "14",
"type": 1,
"loc": "14q32.33"
},
"desc": "X-ray repair cross complementing 3",
"geneType": 5,
"mim": [
{
"id": 600675,
"relation": 0
}
],
"ontology": [
{
"id": "R-HSA-73894",
"term": "DNA Repair",
"cat": 10
},
{
"id": "R-HSA-5693532",
"term": "DNA Double-Strand Break Repair",
"cat": 11
},
{
"id": "R-HSA-5693538",
"term": "Homology Directed Repair",
"cat": 12
},
{
"id": "R-HSA-5693567",
"term": "HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)",
"cat": 13
},
{
"id": "R-HSA-5685942",
"term": "HDR through Homologous Recombination (HRR)",
"cat": 14
},
{
"id": "R-HSA-5693537",
"term": "Resolution of D-Loop Structures",
"cat": 15
},
{
"id": "R-HSA-5693579",
"term": "Homologous DNA Pairing and Strand Exchange",
"cat": 15
},
{
"id": "R-HSA-5693554",
"term": "Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",
"cat": 16
},
{
"id": "R-HSA-5693568",
"term": "Resolution of D-loop Structures through Holliday Junction Intermediates",
"cat": 16
},
{
"id": "GO:0000400",
"term": "four-way junction DNA binding",
"cat": 0
},
{
"id": "GO:0000400",
"term": "four-way junction DNA binding",
"pubMed": [
20207730
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
9469824,
9660962,
11751635,
11842113,
21965664,
24005329,
24141787,
26496610,
28864920,
34591612
],
"cat": 0
},
{
"id": "GO:0005524",
"term": "ATP binding",
"cat": 0
},
{
"id": "GO:0008821",
"term": "crossover junction DNA endonuclease activity",
"pubMed": [
14716019,
23108668
],
"cat": 0
},
{
"id": "GO:0140664",
"term": "ATP-dependent DNA damage sensor activity",
"cat": 0
},
{
"id": "GO:0000722",
"term": "telomere maintenance via recombination",
"cat": 1
},
{
"id": "GO:0000722",
"term": "telomere maintenance via recombination",
"pubMed": [
15507207
],
"cat": 1
},
{
"id": "GO:0000724",
"term": "double-strand break repair via homologous recombination",
"pubMed": [
23149936
],
"cat": 1
},
{
"id": "GO:0006281",
"term": "DNA repair",
"pubMed": [
10422536
],
"cat": 1
},
{
"id": "GO:0006310",
"term": "DNA recombination",
"pubMed": [
9660962
],
"cat": 1
},
{
"id": "GO:0006974",
"term": "DNA damage response",
"pubMed": [
7603995
],
"cat": 1
},
{
"id": "GO:0010824",
"term": "regulation of centrosome duplication",
"pubMed": [
23108668
],
"cat": 1
},
{
"id": "GO:0036297",
"term": "interstrand cross-link repair",
"pubMed": [
26323318
],
"cat": 1
},
{
"id": "GO:0045003",
"term": "double-strand break repair via synthesis-dependent strand annealing",
"cat": 1
},
{
"id": "GO:0071140",
"term": "resolution of mitotic recombination intermediates",
"cat": 1
},
{
"id": "GO:0071140",
"term": "resolution of mitotic recombination intermediates",
"pubMed": [
23108668
],
"cat": 1
},
{
"id": "GO:0090267",
"term": "positive regulation of mitotic cell cycle spindle assembly checkpoint",
"pubMed": [
23108668
],
"cat": 1
},
{
"id": "GO:0090656",
"term": "t-circle formation",
"cat": 1
},
{
"id": "GO:0090656",
"term": "t-circle formation",
"pubMed": [
15507207
],
"cat": 1
},
{
"id": "GO:0090656",
"term": "t-circle formation",
"pubMed": [
21903669
],
"cat": 1
},
{
"id": "GO:0090657",
"term": "telomeric loop disassembly",
"pubMed": [
27918544
],
"cat": 1
},
{
"id": "GO:0090737",
"term": "telomere maintenance via telomere trimming",
"pubMed": [
27918544
],
"cat": 1
},
{
"id": "GO:0000781",
"term": "chromosome, telomeric region",
"pubMed": [
15507207
],
"cat": 2
},
{
"id": "GO:0005634",
"term": "nucleus",
"pubMed": [
16215984,
26323318
],
"cat": 2
},
{
"id": "GO:0005654",
"term": "nucleoplasm",
"cat": 2
},
{
"id": "GO:0005657",
"term": "replication fork",
"cat": 2
},
{
"id": "GO:0005657",
"term": "replication fork",
"pubMed": [
20207730
],
"cat": 2
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"pubMed": [
16215984
],
"cat": 2
},
{
"id": "GO:0005739",
"term": "mitochondrion",
"pubMed": [
20413593
],
"cat": 2
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
},
{
"id": "GO:0033065",
"term": "Rad51C-XRCC3 complex",
"cat": 2
},
{
"id": "GO:0033065",
"term": "Rad51C-XRCC3 complex",
"pubMed": [
11751635
],
"cat": 2
},
{
"id": "GO:0048471",
"term": "perinuclear region of cytoplasm",
"pubMed": [
16215984
],
"cat": 2
}
],
"protein": [
{
"symbol": "XRCC3_HUMAN",
"name": "DNA repair protein XRCC3",
"accession": [
"O43542",
"O43568",
"Q9BU18"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"114480",
"613972",
"114480",
"600675",
"613972"
],
"EMBL": [
"AF035586",
"AF037222",
"AF508041",
"BC001036",
"BC002949",
"BC011725"
],
"CCDS": [
"CCDS9984.1"
],
"RefSeq": [
"NP_001093588.1",
"NP_001093589.1",
"NP_005423.1",
"XP_005268103.1",
"XP_011535440.1"
],
"AlphaFoldDB": [
"O43542"
],
"SASBDB": [
"O43542"
],
"SMR": [
"O43542"
],
"BioGRID": [
"113351"
],
"ComplexPortal": [
"CPX-2182"
],
"CORUM": [
"O43542"
],
"DIP": [
"DIP-42016N"
],
"IntAct": [
"O43542"
],
"MINT": [
"O43542"
],
"STRING": [
"9606.ENSP00000451974"
],
"iPTMnet": [
"O43542"
],
"PhosphoSitePlus": [
"O43542"
],
"BioMuta": [
"XRCC3"
],
"jPOST": [
"O43542"
],
"MassIVE": [
"O43542"
],
"PaxDb": [
"9606-ENSP00000451974"
],
"PeptideAtlas": [
"O43542"
],
"ProteomicsDB": [
"49041"
],
"Pumba": [
"O43542"
],
"Antibodypedia": [
"14778"
],
"DNASU": [
"7517"
],
"Ensembl": [
"ENST00000352127.11",
"ENST00000553264.5",
"ENST00000554913.5",
"ENST00000555055.6"
],
"KEGG": [
"hsa:7517"
],
"MANE-Select": [
"ENST00000555055.6"
],
"AGR": [
"HGNC:12830"
],
"CTD": [
"7517"
],
"DisGeNET": [
"7517"
],
"GeneCards": [
"XRCC3"
],
"HGNC": [
"HGNC:12830"
],
"HPA": [
"ENSG00000126215"
],
"MalaCards": [
"XRCC3"
],
"neXtProt": [
"NX_O43542"
],
"OpenTargets": [
"ENSG00000126215"
],
"PharmGKB": [
"PA37422"
],
"VEuPathDB": [
"HostDB:ENSG00000126215"
],
"eggNOG": [
"KOG1564"
],
"GeneTree": [
"ENSGT00930000151053"
],
"HOGENOM": [
"CLU_041732_1_0_1"
],
"InParanoid": [
"O43542"
],
"OMA": [
"PCLGLQW"
],
"OrthoDB": [
"3177495at2759"
],
"PhylomeDB": [
"O43542"
],
"TreeFam": [
"TF101203"
],
"PathwayCommons": [
"O43542"
],
"Reactome": [
"R-HSA-5685942",
"R-HSA-5693554",
"R-HSA-5693568",
"R-HSA-5693579"
],
"SignaLink": [
"O43542"
],
"SIGNOR": [
"O43542"
],
"BioGRID-ORCS": [
"7517"
],
"ChiTaRS": [
"XRCC3"
],
"GeneWiki": [
"XRCC3"
],
"GenomeRNAi": [
"7517"
],
"Pharos": [
"O43542"
],
"PRO": [
"PR:O43542"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O43542"
],
"Bgee": [
"ENSG00000126215"
],
"ExpressionAtlas": [
"O43542"
],
"GO": [
"GO:0000781",
"GO:0005737",
"GO:0005829",
"GO:0005739",
"GO:0005654",
"GO:0005634",
"GO:0048471",
"GO:0033065",
"GO:0005657",
"GO:0005524",
"GO:0140664",
"GO:0003677",
"GO:0006974",
"GO:0006310",
"GO:0006281",
"GO:0000724",
"GO:0045003",
"GO:0036297",
"GO:0090267",
"GO:0010824",
"GO:0071140",
"GO:0090656",
"GO:0000722",
"GO:0090737",
"GO:0090657"
],
"CDD": [
"cd19491"
],
"Gene3D": [
"3.40.50.300"
],
"InterPro": [
"IPR013632",
"IPR016467",
"IPR027417",
"IPR020588",
"IPR047348"
],
"PANTHER": [
"PTHR46487",
"PTHR46487:SF1"
],
"Pfam": [
"PF08423"
],
"PIRSF": [
"PIRSF005856"
],
"SUPFAM": [
"SSF47789",
"SSF52540"
],
"PROSITE": [
"PS50162"
],
"ChEBI": [
"CHEBI:30616"
]
},
"citations": [
{
"title": "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.",
"pubmedID": "9660962",
"doi": "10.1016/s1097-2765(00)80078-7"
},
{
"title": "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).",
"pubmedID": "15489334",
"doi": "10.1101/gr.2596504"
},
{
"title": "Identification and purification of two distinct complexes containing the five RAD51 paralogs.",
"pubmedID": "11751635",
"doi": "10.1101/gad.947001"
},
{
"title": "Variants in DNA double-strand break repair genes and breast cancer susceptibility.",
"pubmedID": "12023982",
"doi": "10.1093/hmg/11.12.1399"
},
{
"title": "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.",
"pubmedID": "11744692",
"doi": "10.1074/jbc.m108306200"
},
{
"title": "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.",
"pubmedID": "11842113",
"doi": "10.1093/nar/30.4.1009"
},
{
"title": "Domain mapping of the Rad51 paralog protein complexes.",
"pubmedID": "14704354",
"doi": "10.1093/nar/gkg925"
},
{
"title": "RAD51C is required for Holliday junction processing in mammalian cells.",
"pubmedID": "14716019",
"doi": "10.1126/science.1093037"
},
{
"title": "Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51.",
"pubmedID": "16215984",
"doi": "10.1002/jcb.20640"
},
{
"title": "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.",
"pubmedID": "17525332",
"doi": "10.1126/science.1140321"
},
{
"title": "Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome.",
"pubmedID": "20413593",
"doi": "10.1074/jbc.m109.099846"
},
{
"title": "Initial characterization of the human central proteome.",
"pubmedID": "21269460",
"doi": "10.1186/1752-0509-5-17"
},
{
"title": "hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair.",
"pubmedID": "21965664",
"doi": "10.1074/jbc.m111.271080"
},
{
"title": "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.",
"pubmedID": "22814378",
"doi": "10.1073/pnas.1210303109"
},
{
"title": "The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy.",
"pubmedID": "23108668",
"doi": "10.1242/jcs.114595"
},
{
"title": "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.",
"pubmedID": "23149936",
"doi": "10.1128/mcb.00465-12"
},
{
"title": "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.",
"pubmedID": "24141787",
"doi": "10.1038/onc.2013.421"
},
{
"title": "Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy.",
"pubmedID": "20207730",
"doi": "10.1074/jbc.m109.074286"
},
{
"title": "A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.",
"pubmedID": "11059748"
},
{
"title": "DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma.",
"pubmedID": "12376526"
},
{
"title": "Variant XRCC3 implicated in cancer is functional in homology-directed repair of double-strand breaks.",
"pubmedID": "12037675",
"doi": "10.1038/sj.onc.1205539"
},
{
"title": "XRCC3 T241M polymorphism and melanoma skin cancer risk: A meta-analysis.",
"pubmedID": "26137085",
"doi": "10.3892/ol.2015.3040"
},
{
"title": "Quantitative assessment of the influence of X-ray repair cross-complementing group 3 rs861539 polymorphism and cutaneous melanoma susceptibility.",
"pubmedID": "26922354",
"doi": "10.1007/s00403-016-1629-8"
}
],
"sequence": {
"length": 346,
"mass": 37850,
"checksum": "4DDF3B163C3B3332",
"modified": {
"$date": {
"$numberLong": "896659200000"
}
},
"version": 1,
"sequence": "MDLDLLDLNPRIIAAIKKAKLKSVKEVLHFSGPDLKRLTNLSSPEVWHLLRTASLHLRGSSILTALQLHQQKERFPTQHQRLSLGCPVLDALLRGGLPLDGITELAGRSSAGKTQLALQLCLAVQFPRQHGGLEAGAVYICTEDAFPHKRLQQLMAQQPRLRTDVPGELLQKLRFGSQIFIEHVADVDTLLECVNKKVPVLLSRGMARLVVIDSVAAPFRCEFDSQASAPRARHLQSLGATLRELSSAFQSPVLCINQVTEAMEEQGAAHGPLGFWDERVSPALGITWANQLLVRLLADRLREEEAALGCPARTLRVLSAPHLPPSSCSYTISAEGVRGTPGTQSH"
},
"existence": 0,
"relevance": 1,
"proteinID": 3366522496
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}