Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 8484
{
"geneID": 8484,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"CP068256.2"
]
},
"genePos": {
"start": 37823382,
"end": 37825485
},
"orientation": true,
"symbol": "GALR3",
"created": {
"$date": {
"$numberLong": "1738333349527"
}
},
"crossReference": {
"enseGeneID": "ENSG00000128310",
"enseRnaID": [
"ENST00000249041.3"
],
"enseProtID": [
"ENSP00000249041.2"
]
},
"chrom": {
"pos": "22",
"type": 1,
"loc": "22q13.1"
},
"desc": "galanin receptor 3",
"geneType": 5,
"ontology": [
{
"id": "R-HSA-162582",
"term": "Signal Transduction",
"cat": 10
},
{
"id": "R-HSA-372790",
"term": "Signaling by GPCR",
"cat": 11
},
{
"id": "R-HSA-388396",
"term": "GPCR downstream signalling",
"cat": 12
},
{
"id": "R-HSA-500792",
"term": "GPCR ligand binding",
"cat": 12
},
{
"id": "R-HSA-373076",
"term": "Class A/1 (Rhodopsin-like receptors)",
"cat": 13
},
{
"id": "R-HSA-418594",
"term": "G alpha (i) signalling events",
"cat": 13
},
{
"id": "R-HSA-375276",
"term": "Peptide ligand-binding receptors",
"cat": 14
},
{
"id": "GO:0004966",
"term": "galanin receptor activity",
"cat": 0
},
{
"id": "GO:0004966",
"term": "galanin receptor activity",
"pubMed": [
9832121,
24517231
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"pubMed": [
24517231
],
"cat": 0
},
{
"id": "GO:0017046",
"term": "peptide hormone binding",
"pubMed": [
9832121
],
"cat": 0
},
{
"id": "GO:0007187",
"term": "G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
"pubMed": [
9832121
],
"cat": 1
},
{
"id": "GO:0007188",
"term": "adenylate cyclase-modulating G protein-coupled receptor signaling pathway",
"cat": 1
},
{
"id": "GO:0007194",
"term": "negative regulation of adenylate cyclase activity",
"cat": 1
},
{
"id": "GO:0007218",
"term": "neuropeptide signaling pathway",
"cat": 1
},
{
"id": "GO:0007268",
"term": "chemical synaptic transmission",
"pubMed": [
9722565
],
"cat": 1
},
{
"id": "GO:0007611",
"term": "learning or memory",
"pubMed": [
9722565
],
"cat": 1
},
{
"id": "GO:0007631",
"term": "feeding behavior",
"pubMed": [
9722565
],
"cat": 1
},
{
"id": "GO:0045944",
"term": "positive regulation of transcription by RNA polymerase II",
"pubMed": [
24517231
],
"cat": 1
},
{
"id": "GO:0090663",
"term": "galanin-activated signaling pathway",
"pubMed": [
9832121
],
"cat": 1
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"cat": 2
},
{
"id": "GO:0005929",
"term": "cilium",
"pubMed": [
28154160
],
"cat": 2
},
{
"id": "GO:0016020",
"term": "membrane",
"pubMed": [
9722565
],
"cat": 2
},
{
"id": "GO:0045202",
"term": "synapse",
"cat": 2
},
{
"id": "GO:0097730",
"term": "non-motile cilium",
"cat": 2
}
],
"protein": [
{
"symbol": "GALR3_HUMAN",
"name": "Galanin receptor type 3",
"accession": [
"O60755",
"Q53YJ4"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EMBL": [
"AF073799",
"AF067733",
"AF129514",
"AF129513",
"AY587582",
"AB065934",
"Z97630",
"CH471095"
],
"CCDS": [
"CCDS13958.1"
],
"RefSeq": [
"NP_003605.1"
],
"AlphaFoldDB": [
"O60755"
],
"SMR": [
"O60755"
],
"BioGRID": [
"114058"
],
"IntAct": [
"O60755"
],
"STRING": [
"9606.ENSP00000249041"
],
"BindingDB": [
"O60755"
],
"ChEMBL": [
"CHEMBL2731"
],
"GuidetoPHARMACOLOGY": [
"245"
],
"GlyCosmos": [
"O60755"
],
"GlyGen": [
"O60755"
],
"iPTMnet": [
"O60755"
],
"PhosphoSitePlus": [
"O60755"
],
"BioMuta": [
"GALR3"
],
"MassIVE": [
"O60755"
],
"PaxDb": [
"9606-ENSP00000249041"
],
"PeptideAtlas": [
"O60755"
],
"Antibodypedia": [
"12147"
],
"DNASU": [
"8484"
],
"Ensembl": [
"ENST00000249041.3"
],
"KEGG": [
"hsa:8484"
],
"MANE-Select": [
"ENST00000249041.3"
],
"UCSC": [
"uc003aub.1"
],
"AGR": [
"HGNC:4134"
],
"CTD": [
"8484"
],
"DisGeNET": [
"8484"
],
"GeneCards": [
"GALR3"
],
"HGNC": [
"HGNC:4134"
],
"HPA": [
"ENSG00000128310"
],
"MIM": [
"603692"
],
"neXtProt": [
"NX_O60755"
],
"OpenTargets": [
"ENSG00000128310"
],
"PharmGKB": [
"PA28547"
],
"VEuPathDB": [
"HostDB:ENSG00000128310"
],
"eggNOG": [
"KOG3656"
],
"GeneTree": [
"ENSGT01120000271840"
],
"HOGENOM": [
"CLU_009579_6_4_1"
],
"InParanoid": [
"O60755"
],
"OMA": [
"YQIVHYH"
],
"OrthoDB": [
"2915794at2759"
],
"PhylomeDB": [
"O60755"
],
"TreeFam": [
"TF315737"
],
"PathwayCommons": [
"O60755"
],
"Reactome": [
"R-HSA-375276",
"R-HSA-418594"
],
"SignaLink": [
"O60755"
],
"SIGNOR": [
"O60755"
],
"BioGRID-ORCS": [
"8484"
],
"ChiTaRS": [
"GALR3"
],
"GeneWiki": [
"Galanin_receptor_3"
],
"GenomeRNAi": [
"8484"
],
"Pharos": [
"O60755"
],
"PRO": [
"PR:O60755"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O60755"
],
"Bgee": [
"ENSG00000128310"
],
"GO": [
"GO:0005929",
"GO:0016020",
"GO:0097730",
"GO:0005886",
"GO:0045202",
"GO:0004966",
"GO:0017046",
"GO:0007188",
"GO:0007268",
"GO:0007631",
"GO:0007187",
"GO:0090663",
"GO:0007611",
"GO:0007218",
"GO:0045944"
],
"CDD": [
"cd15097"
],
"Gene3D": [
"1.20.1070.10"
],
"InterPro": [
"IPR000405",
"IPR003908",
"IPR000276",
"IPR017452"
],
"PANTHER": [
"PTHR24230",
"PTHR24230:SF17"
],
"Pfam": [
"PF00001"
],
"PRINTS": [
"PR01420",
"PR00663",
"PR00237"
],
"SUPFAM": [
"SSF81321"
],
"PROSITE": [
"PS00237",
"PS50262"
]
},
"citations": [
{
"title": "Cloned human and rat galanin GALR3 receptors: pharmacology and activation of G-protein inwardly rectifying K+ channels.",
"pubmedID": "9722565",
"doi": "10.1074/jbc.273.36.23321"
},
{
"title": "Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.",
"pubmedID": "9832121",
"doi": "10.1046/j.1471-4159.1998.71062239.x"
},
{
"title": "Structural organization and chromosomal localization of three human galanin receptor genes.",
"pubmedID": "9928159",
"doi": "10.1111/j.1749-6632.1998.tb10683.x"
},
{
"title": "The DNA sequence of human chromosome 22.",
"pubmedID": "10591208",
"doi": "10.1038/990031"
},
{
"title": "Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III.",
"pubmedID": "24517231",
"doi": "10.1210/en.2013-2106"
},
{
"title": "Galanin pathogenic mutations in temporal lobe epilepsy.",
"pubmedID": "25691535",
"doi": "10.1093/hmg/ddv060"
}
],
"sequence": {
"length": 368,
"mass": 39573,
"checksum": "E8F46B66422C3150",
"modified": {
"$date": {
"$numberLong": "901929600000"
}
},
"version": 1,
"sequence": "MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE"
},
"existence": 0,
"relevance": 1,
"proteinID": 3523835664
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}