Details Currently Unavailable
A detailed, interactive page could not be generated for the requested gene. This usually happens when there is no significant expression data (CSI) available for it in our database.
AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 9098
{
"geneID": 9098,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC012146.25"
]
},
"genePos": {
"start": 5116032,
"end": 5174991
},
"orientation": false,
"symbol": "USP6",
"created": {
"$date": {
"$numberLong": "1738333349794"
}
},
"crossReference": {
"enseGeneID": "ENSG00000129204",
"enseRnaID": [
"ENST00000574788.6"
],
"enseProtID": [
"ENSP00000460380.1"
]
},
"chrom": {
"pos": "17",
"type": 1,
"loc": "17p13.2"
},
"desc": "ubiquitin specific peptidase 6",
"geneType": 5,
"ontology": [
{
"id": "GO:0003676",
"term": "nucleic acid binding",
"pubMed": [
1565468
],
"cat": 0
},
{
"id": "GO:0004197",
"term": "cysteine-type endopeptidase activity",
"pubMed": [
9827704
],
"cat": 0
},
{
"id": "GO:0004843",
"term": "cysteine-type deubiquitinase activity",
"cat": 0
},
{
"id": "GO:0004843",
"term": "cysteine-type deubiquitinase activity",
"pubMed": [
16127172
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
12612085,
15509780,
16127172,
16555005
],
"cat": 0
},
{
"id": "GO:0005516",
"term": "calmodulin binding",
"cat": 0
},
{
"id": "GO:0006508",
"term": "proteolysis",
"cat": 1
},
{
"id": "GO:0016579",
"term": "protein deubiquitination",
"pubMed": [
16127172
],
"cat": 1
},
{
"id": "GO:0036211",
"term": "protein modification process",
"pubMed": [
9827704
],
"cat": 1
},
{
"id": "GO:0060627",
"term": "regulation of vesicle-mediated transport",
"pubMed": [
15509780
],
"cat": 1
},
{
"id": "GO:0099149",
"term": "regulation of postsynaptic neurotransmitter receptor internalization",
"pubMed": [
31841517
],
"cat": 1
},
{
"id": "GO:0005737",
"term": "cytoplasm",
"pubMed": [
12612085
],
"cat": 2
},
{
"id": "GO:0005764",
"term": "lysosome",
"pubMed": [
9827704
],
"cat": 2
},
{
"id": "GO:0005794",
"term": "Golgi apparatus",
"cat": 2
},
{
"id": "GO:0005886",
"term": "plasma membrane",
"pubMed": [
12612085
],
"cat": 2
},
{
"id": "GO:0055037",
"term": "recycling endosome",
"pubMed": [
15509780
],
"cat": 2
},
{
"id": "GO:0098978",
"term": "glutamatergic synapse",
"pubMed": [
31841517
],
"cat": 2
},
{
"id": "GO:0099092",
"term": "postsynaptic density, intracellular component",
"pubMed": [
31841517
],
"cat": 2
}
],
"geneRelations": [
{
"type": 8,
"similarGenes": [
"162632"
]
}
],
"protein": [
{
"symbol": "UBP6_HUMAN",
"name": "Ubiquitin carboxyl-terminal hydrolase 6",
"accession": [
"P35125",
"B9A6N0",
"Q15634",
"Q86WP6",
"Q8IWT4"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"EC": [
"3.4.19.12",
"3.4.19.12"
],
"EMBL": [
"X63546",
"X63547",
"AY143550",
"AY163314",
"AB449915",
"AC012146",
"CH471108"
],
"CCDS": [
"CCDS11069.2"
],
"PIR": [
"S57867",
"S57868",
"S57874"
],
"RefSeq": [
"NP_001291213.1",
"NP_004496.2",
"XP_011522352.1",
"XP_011522353.1",
"XP_011522354.1",
"XP_011522355.1",
"XP_011522356.1",
"XP_011522357.1",
"XP_011522358.1",
"XP_011522361.1",
"XP_016880779.1"
],
"AlphaFoldDB": [
"P35125"
],
"SMR": [
"P35125"
],
"BioGRID": [
"114552"
],
"IntAct": [
"P35125"
],
"STRING": [
"9606.ENSP00000460380"
],
"BindingDB": [
"P35125"
],
"ChEMBL": [
"CHEMBL4630817"
],
"MEROPS": [
"C19.009",
"C19.044"
],
"iPTMnet": [
"P35125"
],
"PhosphoSitePlus": [
"P35125"
],
"BioMuta": [
"USP6"
],
"DMDM": [
"50403738"
],
"jPOST": [
"P35125"
],
"MassIVE": [
"P35125"
],
"PaxDb": [
"9606-ENSP00000460380"
],
"PeptideAtlas": [
"P35125"
],
"ProteomicsDB": [
"54980",
"54981",
"54982"
],
"Antibodypedia": [
"11505"
],
"DNASU": [
"9098"
],
"Ensembl": [
"ENST00000250066.6",
"ENST00000572949.5",
"ENST00000574788.6"
],
"KEGG": [
"hsa:9098"
],
"MANE-Select": [
"ENST00000574788.6"
],
"UCSC": [
"uc002gau.2"
],
"AGR": [
"HGNC:12629"
],
"CTD": [
"9098"
],
"DisGeNET": [
"9098"
],
"GeneCards": [
"USP6"
],
"HGNC": [
"HGNC:12629"
],
"HPA": [
"ENSG00000129204"
],
"MalaCards": [
"USP6"
],
"MIM": [
"604334"
],
"neXtProt": [
"NX_P35125"
],
"OpenTargets": [
"ENSG00000129204"
],
"Orphanet": [
"477742"
],
"PharmGKB": [
"PA37254"
],
"VEuPathDB": [
"HostDB:ENSG00000129204"
],
"eggNOG": [
"KOG1102",
"KOG1870"
],
"GeneTree": [
"ENSGT00940000155797"
],
"HOGENOM": [
"CLU_005123_0_0_1"
],
"InParanoid": [
"P35125"
],
"OrthoDB": [
"4687814at2759"
],
"PhylomeDB": [
"P35125"
],
"TreeFam": [
"TF324190"
],
"PathwayCommons": [
"P35125"
],
"SignaLink": [
"P35125"
],
"SIGNOR": [
"P35125"
],
"BioGRID-ORCS": [
"9098"
],
"ChiTaRS": [
"USP6"
],
"GeneWiki": [
"USP6"
],
"GenomeRNAi": [
"9098"
],
"Pharos": [
"P35125"
],
"PRO": [
"PR:P35125"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"P35125"
],
"Bgee": [
"ENSG00000129204"
],
"ExpressionAtlas": [
"P35125"
],
"GO": [
"GO:0005737",
"GO:0098978",
"GO:0005794",
"GO:0005764",
"GO:0005886",
"GO:0099092",
"GO:0055037",
"GO:0005516",
"GO:0004843",
"GO:0004197",
"GO:0003676",
"GO:0016579",
"GO:0036211",
"GO:0006508",
"GO:0099149",
"GO:0060627"
],
"Gene3D": [
"3.90.70.10",
"1.10.8.270",
"1.10.10.750",
"1.10.472.80"
],
"InterPro": [
"IPR038765",
"IPR001394",
"IPR000195",
"IPR035969",
"IPR050185",
"IPR018200",
"IPR028889"
],
"PANTHER": [
"PTHR21646",
"PTHR21646:SF96"
],
"Pfam": [
"PF00566",
"PF00443"
],
"SMART": [
"SM00164"
],
"SUPFAM": [
"SSF54001",
"SSF47923"
],
"PROSITE": [
"PS50086",
"PS00972",
"PS00973",
"PS50235"
]
},
"citations": [
{
"title": "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells.",
"pubmedID": "1565468"
},
{
"title": "The Tre2 (USP6) oncogene is a hominoid-specific gene.",
"pubmedID": "12604796",
"doi": "10.1073/pnas.0437015100"
},
{
"title": "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.",
"pubmedID": "19077034",
"doi": "10.1111/j.1365-2443.2008.01251.x"
},
{
"title": "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.",
"pubmedID": "16625196",
"doi": "10.1038/nature04689"
},
{
"title": "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene.",
"pubmedID": "8247125",
"doi": "10.1038/366313a0"
},
{
"title": "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.",
"pubmedID": "14521938",
"doi": "10.1016/j.bbrc.2003.09.051"
},
{
"title": "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling.",
"pubmedID": "12612085",
"doi": "10.1128/mcb.23.6.2151-2161.2003"
},
{
"title": "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst.",
"pubmedID": "15026324",
"doi": "10.1158/0008-5472.can-03-2827"
},
{
"title": "The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6.",
"pubmedID": "15509780",
"doi": "10.1128/mcb.24.22.9752-9762.2004"
},
{
"title": "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.",
"pubmedID": "16127172",
"doi": "10.1074/jbc.m505220200"
},
{
"title": "A quantitative atlas of mitotic phosphorylation.",
"pubmedID": "18669648",
"doi": "10.1073/pnas.0805139105"
},
{
"title": "TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NF-kappaB.",
"pubmedID": "20418905",
"doi": "10.1038/onc.2010.116"
}
],
"sequence": {
"length": 1406,
"mass": 158658,
"checksum": "D3A6822CEB441DB3",
"modified": {
"$date": {
"$numberLong": "1090195200000"
}
},
"version": 2,
"sequence": "MDMVENADSLQAQERKDILMKYDKGHRAGLPEDKGPEPVGINSSIDRFGILHETELPPVTAREAKKIRREMTRTSKWMEMLGEWETYKHSSKLIDRVYKGIPMNIRGPVWSVLLNIQEIKLKNPGRYQIMKERGKRSSEHIHHIDLDVRTTLRNHVFFRDRYGAKQRELFYILLAYSEYNPEVGYCRDLSHITALFLLYLPEEDAFWALVQLLASERHSLPGFHSPNGGTVQGLQDQQEHVVPKSQPKTMWHQDKEGLCGQCASLGCLLRNLIDGISLGLTLRLWDVYLVEGEQVLMPITSIALKVQQKRLMKTSRCGLWARLRNQFFDTWAMNDDTVLKHLRASTKKLTRKQGDLPPPAKREQGSLAPRPVPASRGGKTLCKGYRQAPPGPPAQFQRPICSASPPWASRFSTPCPGGAVREDTYPVGTQGVPSLALAQGGPQGSWRFLEWKSMPRLPTDLDIGGPWFPHYDFEWSCWVRAISQEDQLATCWQAEHCGEVHNKDMSWPEEMSFTANSSKIDRQKVPTEKGATGLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKYTGLKKQLRDLCGLNSEQILLAEVHDSNIKNFPQDNQKVQLSVSGFLCAFEIPVPSSPISASSPTQIDFSSSPSTNGMFTLTTNGDLPKPIFIPNGMPNTVVPCGTEKNFTNGMVNGHMPSLPDSPFTGYIIAVHRKMMRTELYFLSPQENRPSLFGMPLIVPCTVHTRKKDLYDAVWIQVSWLARPLPPQEASIHAQDRDNCMGYQYPFTLRVVQKDGNSCAWCPQYRFCRGCKIDCGEDRAFIGNAYIAVDWHPTALHLRYQTSQERVVDKHESVEQSRRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHCLATKKLDLWRLPPFLIIHLKRFQFVNDQWIKSQKIVRFLRESFDPSAFLVPRDPALCQHKPLTPQGDELSKPRILAREVKKVDAQSSAGKEDMLLSKSPSSLSANISSSPKGSPSSSRKSGTSCPSSKNSSPNSSPRTLGRSKGRLRLPQIGSKNKPSSSKKNLDASKENGAGQICELADALSRGHMRGGSQPELVTPQDHEVALANGFLYEHEACGNGCGDGYSNGQLGNHSEEDSTDDQREDTHIKPIYNLYAISCHSGILSGGHYITYAKNPNCKWYCYNDSSCEELHPDEIDTDSAYILFYEQQGIDYAQFLPKIDGKKMADTSSTDEDSESDYEKYSMLQ"
},
"existence": 0,
"relevance": 1,
"proteinID": 1460081987
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}