Details Currently Unavailable
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AI-Generated Summary
Disclaimer: This summary is AI-generated based on limited data and may be speculative or contain inaccuracies. Detailed expression analysis for this entry is unavailable.
Raw Database JSON for Gene ID: 9119
{
"geneID": 9119,
"tax": {
"id": 9606,
"name": [
{
"name": "Homo sapiens Linnaeus 1758"
},
{
"name": "Homo sapiens",
"type": 0
},
{
"name": "human",
"type": 4
}
]
},
"accession": {
"gene": [
"AC055736.20"
]
},
"genePos": {
"start": 4956,
"end": 15257
},
"orientation": true,
"symbol": "KRT75",
"created": {
"$date": {
"$numberLong": "1738333349795"
}
},
"crossReference": {
"enseGeneID": "ENSG00000170454",
"enseRnaID": [
"ENST00000252245.6"
],
"enseProtID": [
"ENSP00000252245.5"
]
},
"chrom": {
"pos": "12",
"type": 1,
"loc": "12q13.13"
},
"desc": "keratin 75",
"geneType": 5,
"ontology": [
{
"id": "R-HSA-1266738",
"term": "Developmental Biology",
"cat": 10
},
{
"id": "R-HSA-6805567",
"term": "Keratinization",
"cat": 11
},
{
"id": "R-HSA-6809371",
"term": "Formation of the cornified envelope",
"cat": 12
},
{
"id": "GO:0005198",
"term": "structural molecule activity",
"pubMed": [
9856802
],
"cat": 0
},
{
"id": "GO:0005515",
"term": "protein binding",
"pubMed": [
32296183
],
"cat": 0
},
{
"id": "GO:0030280",
"term": "structural constituent of skin epidermis",
"cat": 0
},
{
"id": "GO:0002244",
"term": "hematopoietic progenitor cell differentiation",
"cat": 1
},
{
"id": "GO:0031424",
"term": "keratinization",
"cat": 1
},
{
"id": "GO:0045109",
"term": "intermediate filament organization",
"cat": 1
},
{
"id": "GO:0001533",
"term": "cornified envelope",
"cat": 2
},
{
"id": "GO:0005829",
"term": "cytosol",
"cat": 2
},
{
"id": "GO:0005882",
"term": "intermediate filament",
"pubMed": [
15086549
],
"cat": 2
},
{
"id": "GO:0045095",
"term": "keratin filament",
"cat": 2
},
{
"id": "GO:0070062",
"term": "extracellular exosome",
"pubMed": [
23533145
],
"cat": 2
}
],
"protein": [
{
"symbol": "K2C75_HUMAN",
"name": "Keratin, type II cytoskeletal 75",
"accession": [
"O95678",
"B4DQU4",
"Q9NSA9"
],
"databaseIDs": {
"NCBI Taxonomy": [
"9606"
],
"MIM": [
"600628",
"600628",
"609025",
"612318"
],
"EMBL": [
"Y17282",
"Y19212",
"AK298960",
"AC055736"
],
"CCDS": [
"CCDS8827.1"
],
"RefSeq": [
"NP_004684.2"
],
"AlphaFoldDB": [
"O95678"
],
"SMR": [
"O95678"
],
"BioGRID": [
"114567"
],
"IntAct": [
"O95678"
],
"MINT": [
"O95678"
],
"STRING": [
"9606.ENSP00000252245"
],
"Allergome": [
"415"
],
"GlyGen": [
"O95678"
],
"iPTMnet": [
"O95678"
],
"PhosphoSitePlus": [
"O95678"
],
"SwissPalm": [
"O95678"
],
"BioMuta": [
"KRT75"
],
"jPOST": [
"O95678"
],
"MassIVE": [
"O95678"
],
"PaxDb": [
"9606-ENSP00000252245"
],
"PeptideAtlas": [
"O95678"
],
"PRIDE": [
"O95678"
],
"ProteomicsDB": [
"50995"
],
"Antibodypedia": [
"14610"
],
"DNASU": [
"9119"
],
"Ensembl": [
"ENST00000252245.6"
],
"KEGG": [
"hsa:9119"
],
"MANE-Select": [
"ENST00000252245.6"
],
"UCSC": [
"uc001saj.3"
],
"AGR": [
"HGNC:24431"
],
"CTD": [
"9119"
],
"DisGeNET": [
"9119"
],
"GeneCards": [
"KRT75"
],
"HGNC": [
"HGNC:24431"
],
"HPA": [
"ENSG00000170454"
],
"MalaCards": [
"KRT75"
],
"neXtProt": [
"NX_O95678"
],
"OpenTargets": [
"ENSG00000170454"
],
"PharmGKB": [
"PA147357763"
],
"VEuPathDB": [
"HostDB:ENSG00000170454"
],
"eggNOG": [
"ENOG502RTYA"
],
"GeneTree": [
"ENSGT00940000155862"
],
"HOGENOM": [
"CLU_012560_6_1_1"
],
"InParanoid": [
"O95678"
],
"OMA": [
"SIKKQCS"
],
"OrthoDB": [
"4640531at2759"
],
"PhylomeDB": [
"O95678"
],
"TreeFam": [
"TF317854"
],
"PathwayCommons": [
"O95678"
],
"Reactome": [
"R-HSA-6805567",
"R-HSA-6809371"
],
"SignaLink": [
"O95678"
],
"BioGRID-ORCS": [
"9119"
],
"ChiTaRS": [
"KRT75"
],
"GenomeRNAi": [
"9119"
],
"Pharos": [
"O95678"
],
"PRO": [
"PR:O95678"
],
"Proteomes": [
"UP000005640"
],
"RNAct": [
"O95678"
],
"Bgee": [
"ENSG00000170454"
],
"GO": [
"GO:0001533",
"GO:0005829",
"GO:0070062",
"GO:0005882",
"GO:0045095",
"GO:0030280",
"GO:0005198",
"GO:0002244",
"GO:0045109",
"GO:0031424"
],
"Gene3D": [
"1.20.5.170",
"1.20.5.500",
"1.20.5.1160"
],
"InterPro": [
"IPR018039",
"IPR039008",
"IPR032444",
"IPR003054"
],
"PANTHER": [
"PTHR45616",
"PTHR45616:SF13"
],
"Pfam": [
"PF00038",
"PF16208"
],
"PRINTS": [
"PR01276"
],
"SMART": [
"SM01391"
],
"SUPFAM": [
"SSF64593"
],
"PROSITE": [
"PS00226",
"PS51842"
]
},
"citations": [
{
"title": "A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle.",
"pubmedID": "9856802",
"doi": "10.1046/j.1523-1747.1998.00456.x"
},
{
"title": "Characterization of a 300 kbp region of human DNA containing the type II hair keratin.",
"pubmedID": "10692104",
"doi": "10.1046/j.1523-1747.2000.00910.x"
},
{
"title": "Complete sequencing and characterization of 21,243 full-length human cDNAs.",
"pubmedID": "14702039",
"doi": "10.1038/ng1285"
},
{
"title": "The finished DNA sequence of human chromosome 12.",
"pubmedID": "16541075",
"doi": "10.1038/nature04569"
},
{
"title": "Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles.",
"pubmedID": "14675170",
"doi": "10.1111/j.1523-1747.2003.12644.x"
},
{
"title": "Dermal papilla-induced hair differentiation of adult epithelial stem cells from human skin.",
"pubmedID": "15292489",
"doi": "10.1152/physiolgenomics.00134.2004"
},
{
"title": "Expression of follicular sheath keratins in the normal nail with special reference to the morphological analysis of the distal nail unit.",
"pubmedID": "18032949",
"doi": "10.1097/dad.0b013e318158d741"
},
{
"title": "Is the loose anagen hair syndrome a keratin disorder? A clinical and molecular study.",
"pubmedID": "11939812",
"doi": "10.1001/archderm.138.4.501"
},
{
"title": "An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae.",
"pubmedID": "15086549",
"doi": "10.1111/j.0022-202x.2004.22309.x"
}
],
"sequence": {
"length": 551,
"mass": 59560,
"checksum": "9099CD53A0BAF1EB",
"modified": {
"$date": {
"$numberLong": "1245110400000"
}
},
"version": 2,
"sequence": "MSRQSSITFQSGSRRGFSTTSAITPAAGRSRFSSVSVARSAAGSGGLGRISSAGASFGSRSLYNLGGAKRVSINGCGSSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIAEVKAQYEDIANRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAEQRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEECRLSGEGVSPVNISVVTSTLSSGYGSGSSIGGGNLGLGGGSGYSFTTSGGHSLGAGLGGSGFSATSNRGLGGSGSSVKFVSTTSSSQKSYTH"
},
"existence": 0,
"relevance": 1,
"proteinID": 3556935241
}
],
"singleCellExpressions": {
"cellSignificanceIndex": []
}
}