Details for: WDR86 AS1

Gene ID: 100131176

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: WDR86 AS1

Ensembl ID: ENSG00000243836

Description: WDR86 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ciliated epithelial cell CL0000067
    CSI 21.29
    rCSI 18.72%
    PRS 98.91
  • lung ciliated cell CL1000271
    CSI 11.85
    rCSI 13.7%
    PRS 99.26
  • group 3 innate lymphoid cell CL0001071
    CSI 7.38
    rCSI 5.55%
    PRS 99.71
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 5.21
    rCSI 11.87%
    PRS 98.87
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 3.24
    rCSI 4.42%
    PRS 100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [WDR86 AS1](/details-gene/100131176) is a long non-coding RNA (lncRNA) located on human chromosome 7q36.1. As an antisense transcript to the protein-coding gene WDR86, its primary function is likely related to the regulation of its sense-strand counterpart. **Overall**, expression data reveals a highly specific and significant enrichment of [WDR86 AS1](/details-gene/100131176) in [ciliated epithelial cells](/details-cell/CL0000067), particularly within the respiratory system, such as [lung ciliated cells](/details-cell/CL1000271). This distinct expression pattern strongly suggests a specialized role in the development, maintenance, or function of cilia. ## Cellular Roles and Expression Landscape The expression profile of [WDR86 AS1](/details-gene/100131176) is dominated by a strong and specific signature in ciliated cell lineages. It is most significant in [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 21.29) and related subtypes like [lung ciliated cell](/details-cell/CL1000271) (CSI: 11.85) and [ciliated columnar cell of tracheobronchial tree](/details-cell/CL0002145) (CSI: 5.21). The high CSI values in these cell types indicate that [WDR86 AS1](/details-gene/100131176) is a defining molecular feature of this cellular machinery. Interestingly, the gene also shows moderate significance in specific immune cell populations, including [group 3 innate lymphoid cells](/details-cell/CL0001071) (CSI: 7.38) and [effector memory CD4-positive, alpha-beta T cells](/details-cell/CL0000905) (CSI: 3.24). The presence of this lncRNA in both epithelial barrier cells and resident immune cells at mucosal surfaces may suggest a coordinated role in host defense or tissue homeostasis in environments like the respiratory tract. ## Pathways and Molecular Function Detailed functional annotations for [WDR86 AS1](/details-gene/100131176) are not yet well-established. However, its designation as an antisense RNA to the *WDR86* gene provides a strong-prior hypothesis for its mechanism of action. Antisense lncRNAs typically regulate the expression of their corresponding sense gene through mechanisms such as transcriptional interference, chromatin modification, or by altering mRNA stability and translation. Therefore, it is highly probable that [WDR86 AS1](/details-gene/100131176) functions to fine-tune the expression of WDR86, a WD repeat-containing protein, within the specialized cellular contexts where it is expressed, primarily ciliated cells. ## Research Directions The specific expression pattern of [WDR86 AS1](/details-gene/100131176) in ciliated cells, coupled with its antisense nature, points toward several key research avenues. **Proposed Hypotheses:** 1. [WDR86 AS1](/details-gene/100131176) acts as a negative regulator of WDR86 protein expression in [ciliated epithelial cells](/details-cell/CL0000067), and this regulatory axis is essential for proper ciliogenesis or the maintenance of ciliary beat frequency. 2. The expression of [WDR86 AS1](/details-gene/100131176) in [group 3 innate lymphoid cells](/details-cell/CL0001071) suggests it may be involved in modulating ILC3 responses to epithelial-derived signals, potentially influencing mucosal immunity in the lung or gut. **Key Experimental Approach:** To test the primary hypothesis of regulatory function, a loss-of-function study could be performed. Human bronchial epithelial cells could be cultured at an air-liquid interface to induce differentiation into a ciliated epithelium. These cultures would then be treated with antisense oligonucleotides (ASOs) designed to specifically degrade [WDR86 AS1](/details-gene/100131176) transcripts. The functional consequences would be assessed by quantifying changes in WDR86 mRNA and protein levels via RT-qPCR and western blot, and by evaluating ciliary structure and function through high-resolution microscopy and ciliary beat frequency analysis. **Therapeutic Potential:** Given its high specificity for ciliated cells, [WDR86 AS1](/details-gene/100131176) could be a promising therapeutic target for diseases involving ciliary dysfunction (ciliopathies), such as primary ciliary dyskinesia or chronic obstructive pulmonary disease (COPD). Therapeutic strategies would likely employ ASO-based technologies. If [WDR86 AS1](/details-gene/100131176) is found to repress WDR86, then ASO-mediated inhibition of the lncRNA could serve as a novel approach to increase WDR86 protein levels, potentially restoring ciliary function in diseases where WDR86 activity is compromised.