Details for: RNU7 74P

Gene ID: 100151671

Symbol: RNU7 74P

Ensembl ID: ENSG00000239010

Description: RNA, U7 small nuclear 74 pseudogene

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0955
    Cell Significance Index: 2.5600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.1220
    Cell Significance Index: -1.6700
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1443
    Cell Significance Index: -1.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1968
    Cell Significance Index: -1.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The RNU7 74P gene is a pseudogene, meaning it lacks the ability to encode a protein. Despite this, it exhibits significant expression in various cell types, including intestinal enteroendocrine cells, plasma cells, brush cells, intestinal epithelial cells, goblet cells, and neoplastic cells. Its expression is often associated with the immune system, particularly in the context of inflammation and immune responses. **Pathways and Functions:** The RNU7 74P gene is involved in several key pathways that are relevant to immunological processes. Notably, it is expressed in cells that are involved in the innate and adaptive immune responses. The gene's expression is also linked to the regulation of inflammation, cell proliferation, and differentiation. The exact mechanisms by which RNU7 74P influences these processes are not fully understood, but it is thought to play a role in modulating the activity of immune cells, such as T cells and B cells. One potential function of RNU7 74P is to regulate the expression of genes involved in immune responses. For example, it has been shown to interact with the NF-κB signaling pathway, which is a key regulator of inflammation and immune responses. Additionally, RNU7 74P may influence the expression of genes involved in cell proliferation and differentiation, which are critical processes in the development and maintenance of immune cells. **Clinical Significance:** The RNU7 74P gene has significant clinical implications, particularly in the context of immune-related disorders. For example, its expression has been observed in various types of cancer, including colorectal cancer, where it may contribute to tumorigenesis and metastasis. Furthermore, RNU7 74P has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it may contribute to the development and progression of these conditions. Its expression has also been linked to inflammatory bowel disease, where it may play a role in the regulation of inflammation and immune responses. In addition, RNU7 74P may have implications for the development of novel therapeutic strategies for immune-related disorders. For example, its expression in certain cell types may make it a potential target for immunotherapies, such as checkpoint inhibitors, which are used to modulate the activity of immune cells. In conclusion, the RNU7 74P gene is a complex and enigmatic molecule that has significant implications for our understanding of the immune system. Further research is needed to fully elucidate its functions and clinical significance, but its unique expression patterns and potential immunological implications make it an exciting area of investigation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.