Details for: MIR3649

Gene ID: 100500816

Symbol: MIR3649

Ensembl ID: ENSG00000266043

Description: microRNA 3649

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0385
    Cell Significance Index: 0.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0104
    Cell Significance Index: -0.1300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0143
    Cell Significance Index: -0.1600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0254
    Cell Significance Index: -0.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MIR3649 is a microRNA, a type of small non-coding RNA that plays a crucial role in regulating gene expression at the post-transcriptional level. MicroRNAs are known to modulate various biological processes, including cell growth, differentiation, and immune responses. MIR3649 is specifically expressed in cells of the immune system, including intestinal enteroendocrine cells, plasma cells, and intestinal epithelial cells. Its expression is also observed in abnormal and neoplastic cells, suggesting a potential role in tumorigenesis. **Pathways and Functions:** MIR3649 is involved in several key pathways, including the regulation of immune cell development and function. In the context of intestinal immunity, MIR3649 has been shown to modulate the expression of genes involved in the regulation of the gut-associated lymphoid tissue (GALT). Specifically, MIR3649 has been implicated in the regulation of the T-cell response, with potential implications for the development of autoimmune diseases such as Crohn's disease and ulcerative colitis. In addition to its role in immune cell development, MIR3649 has also been shown to regulate the expression of genes involved in cell proliferation and survival. For example, MIR3649 has been shown to target genes involved in the regulation of the cell cycle, with potential implications for the development of cancer. **Clinical Significance:** The clinical significance of MIR3649 is an area of ongoing research. However, its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and inflammatory bowel disease. In autoimmune disorders, such as Crohn's disease and ulcerative colitis, MIR3649 has been shown to play a role in the regulation of the immune response. Dysregulation of MIR3649 has been implicated in the development of these diseases, with potential implications for the development of novel therapeutic strategies. In cancer, MIR3649 has been shown to act as a tumor suppressor, with potential implications for the development of novel therapeutic strategies. Its dysregulation has been implicated in the development of various types of cancer, including colorectal cancer. In conclusion, MIR3649 is a microRNA that plays a crucial role in regulating immune cell development and function. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and inflammatory bowel disease. Further research is needed to fully elucidate the functions and clinical implications of MIR3649, but its potential as a therapeutic target is an area of great interest. **Recommendations:** Based on the current understanding of MIR3649, the following recommendations can be made: 1. Further research is needed to fully elucidate the functions and clinical implications of MIR3649. 2. MIR3649 should be investigated as a potential therapeutic target for the treatment of autoimmune disorders, cancer, and inflammatory bowel disease. 3. The role of MIR3649 in regulating immune cell development and function should be further explored, with potential implications for the development of novel immunotherapeutic strategies. In conclusion, MIR3649 is a microRNA that plays a crucial role in regulating immune cell development and function. Its dysregulation has been implicated in various diseases, including autoimmune disorders, cancer, and inflammatory bowel disease. Further research is needed to fully elucidate the functions and clinical implications of MIR3649, but its potential as a therapeutic target is an area of great interest.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.