Details for: GS1 24F4 2

Gene ID: 100652791

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: GS1 24F4 2

Ensembl ID: ENSG00000245857

Description: uncharacterized LOC100652791

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.08
    rCSI 5.28%
    PRS 99.89
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.5
    rCSI 5.26%
    PRS 99.91

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [GS1 24F4 2](/details-gene/100652791) is an uncharacterized non-coding RNA (ncRNA) located on chromosome 8p23.1. **Overall**, expression data indicate a highly specialized role for this gene, with its significance being overwhelmingly concentrated in specific epithelial cells of the kidney nephron. Its function remains to be elucidated, but its expression pattern strongly suggests a potential involvement in the distinct physiological processes of the kidney's distal tubules. ## Cellular Roles and Expression Landscape The expression profile of [GS1 24F4 2](/details-gene/100652791) points to a highly specific function within the renal system. The gene's most significant expression is observed in the [kidney connecting tubule epithelial cell](/details-cell/CL1000768) (CSI: 2.08), a cell type critical for the fine-tuning of electrolyte and water balance. A secondary, though substantially lower, significance is noted in the [kidney distal convoluted tubule epithelial cell](/details-cell/CL1000849) (CSI: 0.50). This restricted expression pattern within two functionally related cell types of the distal nephron suggests that [GS1 24F4 2](/details-gene/100652791) is not a general housekeeping gene but rather a specialist ncRNA. Its role may be tied to establishing or maintaining the unique identity and function of these tubular segments, which are responsible for hormone-regulated transport of ions like sodium, potassium, and calcium. The lack of significant expression in other cell types underscores this specificity, marking it as a potential high-fidelity biomarker for the connecting tubule. ## Pathways and Molecular Function Currently, there is no functional annotation available for [GS1 24F4 2](/details-gene/100652791). As an uncharacterized ncRNA, its molecular mechanism is unknown. It could potentially function as a long non-coding RNA (lncRNA) that regulates gene expression at the transcriptional or post-transcriptional level, serves as a molecular scaffold for protein complexes, or acts as a precursor for smaller functional RNAs. Elucidating its molecular function is a key step toward understanding its biological importance. ## Research Directions The highly specific expression of [GS1 24F4 2](/details-gene/100652791) in the distal nephron provides a strong foundation for targeted functional investigation. **Proposed Hypotheses:** 1. [GS1 24F4 2](/details-gene/100652791) functions as a key regulator of ion channel or transporter expression or activity (e.g., the epithelial sodium channel, ENaC) specifically within [kidney connecting tubule epithelial cell](/details-cell/CL1000768), thereby contributing to electrolyte homeostasis. 2. The expression of [GS1 24F4 2](/details-gene/100652791) is dysregulated in genetic or acquired kidney diseases affecting the distal tubule (tubulopathies), such as Gitelman syndrome or distal renal tubular acidosis, and may contribute to the pathophysiology of these conditions. **Key Experimental Approach:** To test the hypothesis that [GS1 24F4 2](/details-gene/100652791) regulates ion transport, a loss-of-function study could be performed. Using antisense oligonucleotides (ASOs) or a CRISPR-Cas9 approach to specifically target and degrade or delete [GS1 24F4 2](/details-gene/100652791) in a human kidney organoid model, which contains differentiated tubular structures. The impact of its depletion on the expression and localization of key ion transporters could be assessed via single-cell RNA-sequencing and immunofluorescence. Furthermore, functional consequences could be measured through assays that monitor transepithelial ion transport in response to hormonal stimuli like aldosterone. **Therapeutic Potential:** The therapeutic potential of [GS1 24F4 2](/details-gene/100652791) is currently speculative but promising due to its remarkable cell-type specificity. This specificity suggests that targeting it would have minimal off-target effects in other tissues. If future research confirms its role in the pathogenesis of kidney diseases characterized by electrolyte imbalance, it could become an attractive candidate for RNA-based therapies. For instance, ASOs could be designed to inhibit its function in conditions where it is harmfully overexpressed, offering a precise way to modulate renal tubular function.