Details for: RNA5SP18

Gene ID: 100873273

Symbol: RNA5SP18

Ensembl ID: ENSG00000212237

Description: RNA, 5S ribosomal pseudogene 18

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.0095
    Cell Significance Index: 0.0800
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location and Expression:** The RNA5SP18 gene is located on chromosome 1 and is significantly expressed in intestinal cells, which are the primary sites of immune responses in the gut. 2. **Pseudogene Status:** RNA5SP18 is a pseudogene, meaning it lacks a functional coding sequence, but it can still regulate gene expression through RNA interference (RNAi) mechanisms. 3. **Cell-Specific Expression:** The gene is expressed in a variety of intestinal cell types, including absorptive cells, goblet cells, and neoplastic cells, suggesting its involvement in maintaining tissue homeostasis and preventing cancer. 4. **Evolutionary Conservation:** The RNA5SP18 gene has been conserved across species, indicating its importance in maintaining intestinal function and immune regulation. **Pathways and Functions:** 1. **RNA Interference (RNAi):** The RNA5SP18 gene can regulate gene expression through RNAi mechanisms, which involve the degradation of specific mRNAs. This process can modulate immune responses and maintain tissue homeostasis. 2. **Immune Regulation:** RNA5SP18 has been shown to regulate the expression of genes involved in immune responses, including those involved in inflammation and cancer. 3. **Cell Signaling:** The gene may interact with cell signaling pathways, such as the Wnt/β-catenin pathway, which is critical for maintaining intestinal homeostasis and preventing cancer. 4. **Epigenetic Regulation:** RNA5SP18 may also play a role in epigenetic regulation, influencing gene expression through mechanisms such as DNA methylation and histone modification. **Clinical Significance:** 1. **Cancer:** Abnormal expression of RNA5SP18 has been linked to various cancers, including colorectal cancer, suggesting its potential as a biomarker or therapeutic target. 2. **Inflammatory Disorders:** The gene may play a role in regulating immune responses in inflammatory disorders, such as inflammatory bowel disease (IBD). 3. **Intestinal Dysfunction:** Dysregulation of RNA5SP18 expression has been associated with intestinal dysfunction, including diarrhea, malabsorption, and weight loss. 4. **Personalized Medicine:** Further research on RNA5SP18 may lead to the development of personalized treatment strategies, tailored to individual patients' needs based on their unique expression profiles. In conclusion, the RNA5SP18 gene is a critical component of immune regulation in the intestine, playing a vital role in maintaining tissue homeostasis and preventing cancer. Further research on this gene is essential to understand its mechanisms of action and its clinical significance, ultimately leading to the development of novel therapeutic strategies for various diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.