Details for: RNA5SP121

Gene ID: 100873391

Symbol: RNA5SP121

Ensembl ID: ENSG00000252346

Description: RNA, 5S ribosomal pseudogene 121

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0122
    Cell Significance Index: 0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.0112
    Cell Significance Index: 0.1300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0028
    Cell Significance Index: 0.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0004
    Cell Significance Index: 0.0000
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0013
    Cell Significance Index: -0.0200
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0034
    Cell Significance Index: -0.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0067
    Cell Significance Index: -0.0400
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0205
    Cell Significance Index: -0.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNA5SP121 is a 5S ribosomal pseudogene, which implies that it is a non-coding RNA that shares sequence homology with the 5S ribosomal RNA (rRNA) component of ribosomes. Despite its pseudogene status, RNA5SP121 exhibits tissue-specific expression patterns, with significant levels detected in the intestinal epithelium. This expression is not limited to specific cell types, as RNA5SP121 is also found in stromal cells and goblet cells. The expression of RNA5SP121 is also observed in abnormal and neoplastic cells, suggesting a potential role in maintaining tissue homeostasis and possibly contributing to intestinal disease. **Pathways and Functions:** The exact pathways and functions of RNA5SP121 remain unclear, but several possibilities can be proposed based on its expression patterns and tissue-specific localization. One potential function of RNA5SP121 is to regulate ribosome biogenesis and function in the intestinal epithelium. As a 5S rRNA pseudogene, RNA5SP121 may contribute to the assembly and maturation of ribosomes, which are essential for protein synthesis. Additionally, RNA5SP121 may play a role in maintaining the integrity of the intestinal epithelium by regulating the expression of genes involved in cell differentiation and survival. **Clinical Significance:** The clinical significance of RNA5SP121 is an area of active research, with potential implications for the diagnosis and treatment of intestinal diseases. The expression of RNA5SP121 in abnormal and neoplastic cells suggests that this pseudogene may serve as a biomarker for intestinal cancer or other diseases. Furthermore, the regulation of ribosome biogenesis and function by RNA5SP121 may provide a new therapeutic target for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) or colorectal cancer. In conclusion, RNA5SP121 is a pseudogene with tissue-specific expression patterns and potential implications for intestinal health. Further research is needed to elucidate the pathways and functions of RNA5SP121 and to explore its clinical significance in the diagnosis and treatment of intestinal diseases. **Future Directions:** To further elucidate the role of RNA5SP121, future studies should focus on: 1. Elucidating the molecular mechanisms underlying the regulation of ribosome biogenesis and function by RNA5SP121. 2. Investigating the clinical significance of RNA5SP121 as a biomarker for intestinal cancer or other diseases. 3. Exploring the therapeutic potential of RNA5SP121 as a target for the treatment of intestinal diseases. By addressing these knowledge gaps, researchers can gain a deeper understanding of the enigmatic role of RNA5SP121 and its potential implications for intestinal health.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.