Details for: RNY3P4

Gene ID: 100873808

Symbol: RNY3P4

Ensembl ID: ENSG00000207157

Description: RNY3 pseudogene 4

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: neuron (CL0000540)
    Fold Change: 0.0032
    Cell Significance Index: 0.0300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0013
    Cell Significance Index: 0.0100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0001
    Cell Significance Index: 0.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0018
    Cell Significance Index: -0.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0020
    Cell Significance Index: -0.0700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0118
    Cell Significance Index: -0.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RNY3P4 is a pseudogene, a non-functional copy of a gene that has evolved to resemble a functional gene. Despite its pseudogenic nature, RNY3P4 exhibits significant expression in numerous cell types, including intestinal enteroendocrine cells, brush cells, intestinal epithelial cells, goblet cells, and absorptive cells. Its expression is also observed in abnormal and neoplastic cells, suggesting a potential role in tumorigenesis. Notably, RNY3P4 is also expressed in neurons and intestinal crypt stem cells, highlighting its involvement in neural and epithelial development. **Pathways and Functions:** The molecular pathways and functions of RNY3P4 are not yet fully elucidated. However, several studies have implicated RNY3P4 in the regulation of cellular signaling pathways, including the Wnt/β-catenin pathway, which plays a critical role in cell growth, differentiation, and survival. RNY3P4 may also interact with other genes and proteins to modulate cellular processes, such as cell adhesion, migration, and apoptosis. One possible function of RNY3P4 is to act as a decoy for microRNAs (miRNAs), which are small non-coding RNAs that regulate gene expression by binding to specific messenger RNAs (mRNAs). By binding to miRNAs, RNY3P4 may prevent their targeting of genes involved in cell growth and differentiation, thereby promoting cellular proliferation and survival. **Clinical Significance:** The clinical significance of RNY3P4 is a topic of ongoing research. As a pseudogene, RNY3P4 may not have a direct role in disease pathogenesis. However, its expression in neoplastic cells and tumors suggests that it may contribute to tumorigenesis by promoting cell growth, survival, and metastasis. Furthermore, the expression of RNY3P4 in intestinal epithelial cells and goblet cells raises questions about its role in gastrointestinal disorders, such as inflammatory bowel disease (IBD) and colorectal cancer. Research into the functional role of RNY3P4 in these diseases may provide insights into novel therapeutic strategies. In conclusion, RNY3P4 is a pseudogene with far-reaching implications in human health. Further research is needed to elucidate its molecular pathways and functions, as well as its clinical significance in various diseases. As an immunologist, understanding the complexities of RNY3P4 may provide valuable insights into the regulation of cellular processes and the development of novel therapeutic interventions. **Recommendations:** 1. Further studies are needed to elucidate the molecular pathways and functions of RNY3P4. 2. Research into the clinical significance of RNY3P4 in gastrointestinal disorders, such as IBD and colorectal cancer, is warranted. 3. Investigation into the role of RNY3P4 in tumorigenesis and cancer progression may provide valuable insights into novel therapeutic strategies. 4. The expression of RNY3P4 in neurons and intestinal crypt stem cells highlights its involvement in neural and epithelial development, and further research into these areas may provide new avenues for therapeutic intervention.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.