Details for: LINC01819

Gene ID: 102723854

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC01819

Ensembl ID: ENSG00000231826

Description: long intergenic non-protein coding RNA 1819

Cell Significance Landscape

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • extravillous trophoblast CL0008036
    CSI 3.79
    rCSI 4.69%
    PRS 99.93

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [LINC01819](/details-gene/102723854), or Long Intergenic Non-Protein Coding RNA 1819, is a long non-coding RNA (lncRNA) located on human chromosome 2. As a non-coding gene, it does not produce a protein but is presumed to function at the RNA level, likely as a regulator of gene expression. Expression data indicates that [LINC01819](/details-gene/102723854) has a highly specific expression profile, with its most significant presence observed in [extravillous trophoblast](/details-cell/CL0008036) cells. This restricted pattern strongly suggests a specialized role in placental development, particularly in processes related to the maternal-fetal interface. ## Cellular Roles and Expression Landscape The expression landscape of [LINC01819](/details-gene/102723854) is characterized by its remarkable specificity. **Overall**, the gene's most significant expression is found in the [extravillous trophoblast](/details-cell/CL0008036), a specialized and highly invasive cell type originating from the placenta. These cells are critical for a successful pregnancy, as they invade the maternal uterine wall and remodel the spiral arteries to establish adequate blood flow to the developing fetus. The high Cell Significance Index (CSI: 3.79) in this single cell type suggests that [LINC01819](/details-gene/102723854) is not a broadly expressed housekeeping gene but rather a key molecular player whose function is tightly linked to the unique biology of extravillous trophoblasts. Its specific expression pattern points towards a potential role in regulating the complex processes of trophoblast differentiation, migration, and invasion. The absence of significant expression in other surveyed cell types further highlights its potential as a specific marker for this placental cell lineage. ## Pathways and Molecular Function The precise molecular functions and biological pathways associated with [LINC01819](/details-gene/102723854) remain uncharacterized, as there are currently no significant gene ontology (GO) or Reactome pathway annotations available. However, based on its classification as a lncRNA and its specific expression context, it is plausible that [LINC01819](/details-gene/102723854) acts as a regulatory molecule. LncRNAs can influence gene expression through various mechanisms, including acting as scaffolds for protein complexes, serving as guides for chromatin-modifying enzymes to specific genomic loci, or functioning as microRNA sponges. Given its high expression in [extravillous trophoblast](/details-cell/CL0008036) cells, [LINC01819](/details-gene/102723854) may regulate gene networks essential for epithelial-to-mesenchymal transition (EMT), cell invasion, and angiogenesis, all of which are fundamental to the function of these cells. ## Research Directions The highly specific expression of [LINC01819](/details-gene/102723854) in a cell type critical for pregnancy provides a clear path for future investigation into its role in both normal development and pathology. **Proposed Testable Hypotheses:** 1. [LINC01819](/details-gene/102723854) is a positive regulator of the invasive phenotype of [extravillous trophoblast](/details-cell/CL0008036) cells by modulating the expression of genes involved in extracellular matrix degradation and cell motility. 2. Aberrant expression of [LINC01819](/details-gene/102723854) is associated with pregnancy disorders characterized by defective placentation, such as pre-eclampsia, where trophoblast invasion is known to be shallow and incomplete. **Key Experimental Approach:** To test the hypothesis that [LINC01819](/details-gene/102723854) regulates trophoblast invasion, a loss-of-function study could be performed. Using an established human [extravillous trophoblast](/details-cell/CL0008036) cell line (e.g., HTR-8/SVneo), expression of [LINC01819](/details-gene/102723854) could be knocked down using sequence-specific siRNAs or a more stable CRISPR interference (CRISPRi) system. The impact of this knockdown on cellular function could then be assessed using a Matrigel-coated Transwell invasion assay. Concurrently, RNA-sequencing of the knockdown and control cells would identify downstream target genes and pathways regulated by [LINC01819](/details-gene/102723854), providing mechanistic insight into its function. **Therapeutic Potential:** Direct therapeutic targeting of [LINC01819](/details-gene/102723854) is premature given the lack of functional data. However, its high tissue specificity makes it an attractive candidate as a non-invasive biomarker. If [LINC01819](/details-gene/102723854) is secreted in extracellular vesicles from the placenta into the maternal bloodstream, its circulating levels could serve as a specific and sensitive indicator of placental health and potentially aid in the early diagnosis of disorders like pre-eclampsia.